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7?,8?-Dihydroobolactone, a typanocidal ?-pyrone from the rainforest tree Cryptocarya obovata
(Pergamon-Elsevier Science Ltd, 2010) Davis, Rohan A.; Demirkiran, Ozlem; Sykes, Melissa L.; Avery, Vicky M.; Suraweera, Lekha; Fechner, Gregory A.; Quinn, Ronald J.
Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone ( 1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 mu M. (C) 2010 Elsevier Ltd. All rights reserved.