Yazar "Donmez, Murat" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Synthesis methods, characterizations and usage areas of medicinal compounds from THP, and their Ag(I)-NHC complexes, and their antimicrobial efficiencies
    (Ios Press, 2023) Turkyilmaz, Murat; Donmez, Murat
    Natural or synthetic substances can be used to create smart medications, which can enhance cognitive performance in healthy individuals. They are frequently used to boost memory, concentration, creativity, intelligence, and motivation in the fiercely competitive world of today.To achieve optimum results, the drug should be applied to the target site at the appropriate concentration, with as few or no adverse effects as possible due to off-target actions. Recent studies have shown that such drugs, which are often used in chemotherapy, can reduce the level of discomfort cancer patients endure. In this study, metal complexes that can carry silver nanoparticles with electrical and optical properties were formed. This article examines the potential of man-made silver N-heterocyclic complexes as smart drugs. Following the synthesis of new carbene species from the Xthantine compound, metal complexes were produced for this use. The chemical structures of these carbenes and metal complexes were investigated using a variety of methods, including melting point studies, conductivity, H-1-NMR and C-13-NMR, LC-Mass, FT-IR, TGA, and UV-vis spectrophotometry. These metal complexes differ mostly due to their solubility in water. Using the disk diffusion method, the antimicrobial and antibacterial properties of silver(I)-NHC complexes were examined against Gram-positive and Gram-negative bacteria as well as fungi. It has been observed that the antimicrobial activity of 7,9-bis(2-cyanoethyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-9-ium silver(I)bromide compound is high. These data suggest that this compound has strong antibacterial properties.
  • Küçük Resim Yok
    Öğe
    Synthesis, Spectral Analysis and Antimicrobial Activity of New Pd(II) Complexes Involving 5,6-Dimethylbenzimidazole
    (Higher Education Press, 2023) Turkyilmaz, Murat; Donmez, Murat; Altun, Ozlen
    In this study, firstly, 3-bromopropanenitrile(2a), ethyl bromoacetate(2b), and 2-bromoethan-1-amine(2c) were added to 5,6-dimethylbenzimidazole(1) and symmetrically-connected N-heterocyclic carbenes(NHC)[(3a-3c)] were synthesized. Then, the NHC precursor compounds were reacted with PdCl2 and Pd(II)-NHC complexes[(4a-4c)] were obtained. The synthesized NHC precursors(3a-3c) and Pd(II)-NHC complexes(4a-4c) were characterized by different spectroscopic methods. The antibacterial activities of these products were measured against bacteria and fungus with the disc diffusion method. Pd(II)-NHC complexes had higher antibacterial activity than the NHC precursors. The synthesized compounds showed antimicrobial activity with different properties from each other. In vitro biological activities of salts and metal complexes on selected bacteria were determined by the broth dilution method based on Clinical and Laboratory Standards Institute guidelines. 1,3-Bis-(2-hydroxyethyl) imidazolinium bromide and 3-(2-ethoxy-2-oxoethyl)-1-(3-aminopropyl)-1H-imidazole-3-ium bromide had activity against Escherichia coli.