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Öğe Commentary(Medknow Publications & Media Pvt Ltd, 2011) Celtik, Coskun; Karal, Yasemin[Abstract Not Available]Öğe The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin/clavulanate for the treatment of children with acute otitis media(Turkish J Pediatrics, 2007) Biner, Betuel; Celtik, Coskun; Oner, Naci; Kucukugurluoglu, Yasemin; Guzel, Ahmet; Yildirim, Cetin; Adali, Mustafa KemalThe aim of the study was to evaluate the efficacy of short-course antimicrobial therapies [single intramuscular dose of ceftriaxone (50 mg/kg, not exceeding 1 g), 5 days of azithromycin (10 mg/kg on day 1, then 5 mg/kg daily on days 2-5) and the traditional 10-day course of amoxicillin/clavulanate (90/6.4 mg/kg/day in 2 doses)] in children with acute otitis media (AOM). The study was conducted as a prospective, comparative, open randomized trial between February 2001 and April 2003, and 104 children were enrolled, with a mean age of 3.8 (2.3) years. The clinical and otoscopic assessments of the children were made on days 0, 3, 11 and 30 after admission, and tympanometry was performed on day 30. The patients were diagnosed and followed with a scoring system. Clinical success was achieved in 29/34 patients (85.3%) in the ceftriaxone group, 27/31 patients (87.1%) in the azithromycin group and 34/39 children (87.2%) in the arnoxicillin/clavulanate group. The rate of persistence of middle-ear fluid did not differ between the three groups (p>0.05). During the one-month period, no recurrent case was observed. The most common drug-related adverse effects were associated with the gastrointestinal system. In conclusion, for the treatment of children with AOM, the clinical success of single-dose intramuscular ceftriaxone and of five-day azithromycin treatments was comparable to that of the traditional 10-day therapy with high-dose arnoxicillin/clavulanate.Öğe Evaluation of Clinical and Laboratory Features of Epstein-Barr Virus-Associated Acute Infectious Mononucleosis in Children(Aves Yayincilik, Ibrahim Kara, 2008) Celtik, Coskun; Kuecuekugurluoglu, Yasemin; Balci, Demet Benek; Oener, Naci; Duran, Ridvan; Karasalihoglu, SerapObjectives: The various symptoms of infectious mononucleosis associated with Epstein-Barr virus may confuse physicians in differential diagnosis. The aim of this study is to evaluate the clinical and laboratory findings of this disease in symptomatic children. Patients and Methods: This study was retrospectively performed on 52 cases (31 boys, 21 girls; mean age 5.4 +/- 3.4 years; range 1 to 13 years) with acute Epstein-Barr virus infection. The clinical and laboratory findings were evaluated according to admission time after initial complaints (<= 5/>5 days) and the age groups of the cases (<= 2/>2 years). Results: The major symptoms were fever, lymphadenopathy and tonsillopharyngitis in the classical triad. Moreover, atypical cases who had ascites, arthritis and severe abdominal pain were defined. No case had a poor prognosis. The most frequent laboratory finding was lymphocytosis. While the major symptoms were more frequent in the group admission time <= 5 days, the count of atypical lymphocyte were higher in the group admission time > 5 days. However, these differences could not be defined between age groups. Conclusion: Infectious mononucleosis due to Epstein-Barr virus is a disease with good prognosis in children. The features of the disease may vary according to admission time, and this fact should be taken into consideration in the diagnosis.Öğe Factor V Leiden mutation, deficiency of antithrombin III and elevation of factor VIII in a child with ischemic stroke(Elsevier Science Bv, 2006) Duran, Ridvan; Biner, Betul; Demir, Muzaffer; Celtik, Coskun; Karasalihoglu, Serap; Acunas, BetulA 4-year-old boy was admitted with left hemiplegia. Thrombophilia marker examination resulted with factor V Leiden mutation heterozygosity, a deficiency of antithrombin III and a high level of factor VIII. Cranial computed tomography scan revealed an ischemic infarct in the region of right anterior cerebral artery. In the literature, combinations of multiple thrombophilia risk factors that trigger cerebral ischemic stroke in children have been emphasized. To our knowledge, this is the first child with these combinations of thrombophilia risk factors and ischemic stroke to be reported in the literature. (c) 2006 Elsevier B.V. All rights reserved.Öğe Investigation of indoor molds and allergic diseases in public primary schools in Edirne city of Turkey(Allergy Immunol Soc Thailand,, 2011) Celtik, Coskun; Okten, Suzan; Okutan, Ozlem; Aydogdu, Halide; Bostancioglu, Musa; Ekuklu, Galip; Asan, AhmetBackground: Studies evaluating the role of indoor molds in the development of allergic or respiratory symptoms in schools are few in childhood. Objective: This study aimed to investigate relation between indoor molds and allergic diseases or respiratory symptoms in primary school's children in Edirne, Turkey. Methods: Ten public primary schools were included into the study. A thorough assessment, using a questionnaire and inspection surveys was carried out. The concentration of culturable mold was assessed in the dust samples in the schools. Indoor temperature and humidity were measured. A total of 1374 students who completed valid questionnaires were included in the study, and dust-samples were collected from the schools. Results: Cumulative and current prevalence rates of wheezing, asthma, allergic rhinitis, and atopic dermatitis were found as 31.4%, 9.3%, 16.2%, 6.0% and 13.4%, 11.9%, 15.1%, 2.1%, respectively. The most frequent mold-species detected in indoor dusts were Cladosporium, Penicillium, Alternaria and Aspergillus. Although the prevalence rates of allergic diseases and respiratory symptoms were high, indoor mold amounts were low in the schools in our region and no significant correlation was determined between indoor mold amount and the prevalence of these diseases in schools or classrooms. Conclusion: Even though allergic molds are present in schools, the mold-exposure may not be an important predisposing factor for development of allergic and respiratory diseases the schools in our region. (Asian Pac J Allergy Immunol 2011;29:42-9)Öğe The Reasons of Elevated Serum Transaminases in Childhood(Turkish Biochem Soc, 2008) Celtik, Coskun; Erbas, Hakan; Kursun, Oemer Serhat; Bostancioglu, Musa; Inan, Mustafa; Oner, Naci; Acunas, Betuel AysePurpose: To determine the reasons of high serum serum transaminases levels and show the differences according to age and aetiology. Method: During the three years period, 250 cases with elevated serum transaminase levels among the children who hospitalized with various reasons were included to this study. The aetiological factors which caused high serum transaminase levels were classified according to the age groups (newborn, infants and older children). The mean serum transaminase levels were also determined according to aetiological factors. Results: In newborn period, most of the hipertransaminasemia causes were idiopathic. The most frequent pathological causes were perinatal asphyxia, haemolytic diseases and non-hepatitis infections, respectively. The most frequent causes of hipertransaminasemia were drug usage and non-hepatic infections in infancy period, while infectious hepatitis and drug usage were in older children. Among all of the groups, maximum transaminase levels were observed in the patients with infectious hepatitis. Interestingly, in some cases with abdominal blunt trauma, hypertransaminasemia were determined without hepatic injury. Conclusion: The ages and enzyme levels are important for the differential diagnosis of hipertransaminasemia and it should be taken into consideration that high serum transaminase levels could be obtained, even direct hepatic damage had not been observed.Öğe Seroprevalence of autoimmune thyroiditis and celiac disease in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey(Turkish Soc Gastroenterology, 2010) Soyucen, Erdogan; Yilmaz, Sema; Celtik, Coskun; Vatansever, Ulfet; Oner, Naci; Karasalihoglu, SerapBackground/aims: We aimed to estimate the seroprevalence of celiac disease, a gluten-sensitive enteropathy, and autoimmune thyroiditis in children with insulin-dependent diabetes mellitus in the Thrace region of Turkey. Methods: The population studied consisted of 33 children with insulin-dependent diabetes mellitus and 41 healthy children with demographic features similar to the study subjects. Free triiodothyronine, free thyroxine, thyroid-stimulating hormone, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, IgA, anti-endomysium IgA, and anti-gliadin IgA were measured in all cases and controls. Results: The serum levels of free triiodothyronine and free thyroxine were within the normal range in all cases. However, in one patient who had anti-thyroid peroxidase and anti-thyroglobulin antibodies, the thyroid-stimulating hormone level was high despite a normal free triiodothyronine and free thyroxine value. Ultrasonographic findings confirmed thyroiditis in this patient. Anti-thyroid peroxidase antibodies, anti-thyroglobulin antibodies, anti-endomysium IgA and anti-gliadin IgA were detected in 15.4%, 6%, 9.1% and 3% of the diabetic cases, respectively. None of these antibodies was detected in the control group. In the diabetic group, the seroprevalences of the antithyroid peroxidase antibodies and the anti-endomysium IgA were statistically higher than in the control group (p<0.05). Conclusions: Children with insulin-dependent diabetes mellitus in our region should undergo periodic screenings for autoimmune thyroiditis and celiac disease.
