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Öğe Brain metastases occurrence among metastatic breast cancer: A single oncology center experience.(Amer Soc Clinical Oncology, 2005) Uygun, K; Karagol, H; Tokatli, F; Caloglu, M; Donmez, S; Tas, F[Abstract Not Available]Öğe Fatal hepatic veno-occlusive disease in an adult patient with Wilms' tumour(Elsevier Science London, 2003) Uygun, K; Kocak, Z; Cicin, I; Caloglu, M[Abstract Not Available]Öğe Isolated bone metastasis in testicular germ cell tumors: A case report and review of the literature(Karger, 2006) Uygun, K; Karagol, H; Kocak, Z; Cicin, I; Yalcin, O; Caloglu, M; Simsek, OBackground: In testicular germ cell tumors ( GCT), bone metastases are usually seen late in the disease progress and are almost always associated with involvement of other sites. However, isolated bone metastasis is an extremely rare finding in these patients. Case Report: A 43-year-old man was admitted to the neurosurgery department of our hospital suffering from dysarthria, ataxia, headaches and a progressive swelling above the parietooccipital region of the skull. Radiological, biochemical and pathologic tests showed that the lesion of the skull was an isolated skull metastasis as an initial manifestation of nonseminomatous GCT of the testis. Discussion: When a young patient presents with bone pain or painless swelling, even if it is an unusual site and isolated, testicular GCT should be considered as a differential diagnosis, as these lesions could be the first evidence of metastatic GCT.Öğe Pituitary metastasis mimicking a macroadenoma from carcinoma of the larynx: A case report(Pensiero Scientifico Editor, 2001) Uzal, MC; Kocak, Z; Doganay, L; Tokatli, F; Caloglu, M; Kilincer, CMetastatic tumors of the pituitary gland are not commonly diagnosed during life in cancer patients. The occurrence of symptomatic lesions is also very unusual and difficult to differentiate clinically and radiologically from pituitary adenomas. Furthermore, a single intrasellar metastasis from laryngeal carcinoma mimicking a pituitary adenoma is an extremely rare pathological finding. We report on the clinical, radiological, and pathological findings in a patient with laryngeal carcinoma who had a symptomatic solitary pituitary gland metastasis that was recognized antemortem.Öğe The protective effect of amifostine on radiation-induced acute pulmonary toxicity(Elsevier Science Inc, 2004) Uzal, C; Durmus-Altun, G; Caloglu, M; Ergülen, A; Altaner, S; Yigitbasi, NOPurpose: The purpose of this study was to determine by using Tc-99m-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model. Methods and Materials: Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD + AMF). The AMF and RAD + AMF groups received amifostine. The RAD and RAD + AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a Co-60 treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99)mTc-DTPA radioaerosol study was performed 14 day after irradiation. Results: The mean clearance rate of Tc-99m-DTPA in control subjects was 140 +/- 21 min. The highest It, value was noted in the RAD group (603 105 min, p = 0.001). There were no significant differences between the Tc-99m-DTPA lung clearance rates of the CONT, RAD + AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD + AMF are 63% 1.6%, 63% 2.5%, 60% 2.9%, and 63% 2%, respectively. Conclusions: We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury. (C) 2004 Elsevier Inc.
