Yazar "Caliyurt, Okan" seçeneğine göre listele
Listeleniyor 1 - 20 / 21
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Acute sleep deprivation immediately increases serum GDNF, BDNF and VEGF levels in healthy subjects(Springer Japan Kk, 2022) Gorgulu, Yasemin; Caliyurt, Okan; Cinar, Rugul Kose; Sonmez, Mehmet BulentAcute sleep deprivation upregulates hippocampal neurogenesis. Neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) are mediators of neuronal plasticity and neurogenesis. These neurotrophins are involved in sleep and sleep disorders and are associated with sleep deprivation. In this study, it is aimed to investigate the changes of neurotrophin levels with total sleep deprivation in healthy individuals. Seventeen healthy young adults with a mean age of 19.8 (SD = 1.0) years underwent an experimental protocol consisting of 36 h of total sleep deprivation. Venous blood samples were obtained on Day1 at 09.00, on Day2 at 09.00, and at 21.00. Serum levels of neurotrophins were detected using the ELISA method. The participants were asked to mark the scores corresponding to their subjective energy, happiness, depression, tension levels on the visual analog scale; and sleepiness level on the Epworth Sleepiness Scale; during the course of the study. As a result of 36 h of sleep deprivation, serum GDNF, BDNF, and VEGF levels showed a statistically significant increase compared to the baseline values in the participants included in the study (P < 0.0001). While this increase was evident in 24 h, it continued after 36 h. In parallel, sleepiness levels, subjective depression, and tension levels increased, on the other hand, subjective energy and happiness scores decreased at a statistically significant level at the end of the study compared to basal values (P < 0.0001). The results show that acute sleep deprivation significantly affects and increases serum levels of neurotrophic factors, and it seems that these effects are likely to occur as an immediate response to the stress and disruption caused by sleep deprivation.Öğe Öğe Artificial Intelligence as a Psychiatric Diagnostic Tool Instead of DSM(Aves, 2021) Caliyurt, Okan[Abstract Not Available]Öğe Brain metabolism changes with 18F-fluorodeoxyglucose-positron emission tomography in a patient with Cotard's syndrome(Sage Publications Ltd, 2016) Ozkan, Nevlin; Caliyurt, Okan[Abstract Not Available]Öğe The Effect of Acute Total Sleep Deprivation on Energy Metabolism(Aves, 2011) Caliyurt, Okan; Edis, Ebru Cakir; Altiay, GundenizObjective: The aim of the present study was to assess the effects of total sleep deprivation on daily basal energy expenditure. Methods: Twenty healthy volunteers were included in the study. Resting energy expenditure was measured with indirect calorimetry device (Vmax 29c Sensor Medics, Yorba Linda, CA, USA) at 09: 00 a. m., and food was withheld after midnight the prior evening. The measurements were carried out after eight hours of rest in awake subjects at constant ambient (environmental) temperature for at least 20 minutes. After 24 hours of total sleep deprivation, the measurements were repeated. Results: The first-measured mean resting energy expenditure was 1351.10+/-600.37 kcal/24 h and the second measurement revealed slight decrease with a mean value of 1250.60+/-454.39 kcal/24 h, but the difference did not reach the level of statistical significance. The changes in mean resting energy expenditure values before and after total sleep deprivation were evaluated in men and women separately, but no significant difference was observed between the two genders. Mean body mass index values correlated positively and significantly with both first and second resting energy measurements. Conclusion: Our results showed that total sleep deprivation did not directly affect daily basal energy expenditure. Sleep deprivation, sleep disorders and insomnia are associated with metabolic changes. Those metabolic effects are more likely related to chronic sleep restriction and changes in appetite and glucose metabolism that may cause weight gain and diabetes, rather than being direct effects on energy expenditure. (Archives of Neuropsychiatry 2011; 48: 17-21)Öğe Effects of Psychiatric Disorders on Women in Sustainable Business(Springer-Verlag Singapore Pte Ltd, 2018) Caliyurt, Okan[Abstract Not Available]Öğe Effects of Selective Serotonin Reuptake Inhibitors on Macular Ganglion Cell Complex Thickness and Peripapillary Retinal Nerve Fiber Layer Thickness(Taylor & Francis Inc, 2018) Guclu, Hande; Gorgulu, Yasemin; Gurlu, Vuslat Pelitli; Cinar, Rugul Kose; Ozal, Sadik Altan; Caliyurt, OkanPurpose: To evaluate macular ganglion cell complex (GCC) thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in patients treated with SSRIs.Methods: The present study included 62 eyes of 31 patients who were using SSRIs and 60 eyes of 30 healthy, age- and gender-matched control subjects. All patients underwent a full ophthalmological examination in which macular thickness, GCC thickness, and peripapillary RNFL thickness were measured using optical coherence tomography (OCT). The Mann-Whitney U test was used to compare the patients' group with the age- and gender-matched control group. Pearson correlation analyses were also performed to assess the relationships between macular thickness, GCC thickness, RNFL thickness, and the duration of SSRI usage.Results: The mean duration of SSRI usage was 29.9627.19 (range 6-120) months. The foveal thickness was 253.48 +/- 22.77 mu m in the patients' group and 266.60 +/- 20.64 mu m in the control group; the difference between the groups was statistically significant. In addition, the perifoveal GCC thickness in the inferonasal and inferotemporal quadrant were significantly smaller thinner in the patient group (Mann-Whitney U test, p=0.021and p=0.013, respectively).Conclusions: Our results suggest a relation between SSRIs and decreased retinal GCC thickness and RNFL thickness. Future long-term prospective studies should elucidate the actual effect of SSRIs on GCC and RNFL thickness.Öğe Ethical Evaluation of the Duty to Report Patients Crimes in Turkish Psychiatric Practice(Springer-Verlag Singapore Pte Ltd, 2018) Caliyurt, Okan[Abstract Not Available]Öğe Evidence for the Efficacy of Bright Light Therapy for Bipolar Depression(Amer Psychiatric Publishing, Inc, 2018) Benedetti, Francesco; Avery, David H.; Bauer, Michael; Bunney, William E.; Caliyurt, Okan; Camardese, Giovanni; Colombo, Cristina[Abstract Not Available]Öğe Hyponatremia associated with escitalopram use in a young woman(Kure Iletisim Grubu A S, 2011) Caliyurt, Okan; Derici, SedaSelective serotonin re-uptake inhibitors have an increased usage in clinical practice and safe side effect profile. Hyponatremia is a rare but important and sometimes fatal side effect of SSRIs especially in elderly woman. In this paper, we report hyponatremia associated with escitalopram use in the youngest female patient in the literature so far. The reported case is a 17 year old female patient with Major Depressive Disorder developed acute hyponatremia. In the report we described early diagnosis of her hyponatremia and the connection with her medication. The treatment including cessation of escitalopram and fluid and electrolyte replacement was successful. In conclusion, it is clinically important to be aware of hyponatremia as an important side effect of SSRIs and young patients could also develop hyponatremia.Öğe Mental Health and Psychosocial Support Needed by Refugees in the COVID-19 Pandemic(Aves, 2021) Caliyurt, Okan[Abstract Not Available]Öğe The Mental Health Consequences of the Global Housing Crisis(Aves, 2022) Caliyurt, Okan[Abstract Not Available]Öğe Perceived occupational competence and value among university students with premenstrual dysphoric disorder(Sage Publications Ltd, 2022) Pekcetin, Serkan; Ozdinc, Sevgi; Ata, Hilal; Can, Hilal Basak; Aydin, Nimet Sermenli; Durmus, Pelin Tas; Caliyurt, OkanIntroduction Premenstrual dysphoric disorder (PMDD) is defined as a mental health issue and is assessed using DSM-V diagnostic criteria. Premenstrual dysphoric disorder comprises emotional, behavioral, and physical symptoms that occur in the premenstrual phase and resolve shortly after the start of menstruation. These symptoms and functional impairment may negatively affect occupational competence and value. This study investigated perceived occupational competence and value in university students with premenstrual dysphoric disorder. Methods This cross-sectional study was performed at a public university with 35 students with PMDD and 35 age-matched students without PMDD. Occupational competence and value were evaluated using the Occupational Self-Assessment (OSA). Results There was a significant difference between the groups in OSA competence score (p < 0.05), while there was no significant difference in OSA value score (p > 0.05). Conclusion This study demonstrated that university students with PMDD experience more occupational competence challenges than peers without PMDD. Further studies should be performed to determine the role of occupational therapy in the rehabilitation of PMDD.Öğe Proinflammatory cytokine levels in patients with conversion disorder(Cambridge Univ Press, 2013) Tiyekli, Utkan; Caliyurt, Okan; Tiyekli, Nimet DilekObjective: It was aimed to evaluate the relationship between proinflammatory cytokine levels and conversion disorder both commonly known as stress regulated. Method: Baseline proinflammatory cytokine levels-[Tumour necrosis factor alpha (TNF-alpha), Interleukin-1 beta (IL-1 beta), Interleukin-6 (IL-6)]-were evaluated with enzyme-linked immunosorbent assay in 35 conversion disorder patients and 30 healthy controls. Possible changes in proinflammatory cytokine levels were evaluated again, after their acute phase in conversion disorder patients. Results: Statistically significant decreased serum TNF-alpha levels were obtained in acute phase of conversion disorder. Those levels increased after acute conversion phase. There were no statistically significant difference observed between groups in serum IL-1 beta and (IL-6) levels. Conclusions: Stress associated with conversion disorder may suppress immune function in acute conversion phase and may have diagnostic and therapeutic value.Öğe Psychiatric Treatment Approaches in the Post-COVID-19 Period(Aves, 2021) Caliyurt, Okan[Abstract Not Available]Öğe Rapid antidepressant effects of sleep deprivation therapy correlates with serum BDNF changes in major depression(Pergamon-Elsevier Science Ltd, 2009) Gorgulu, Yasemin; Caliyurt, OkanRecent reports have suggested that brain-derived neurotrophic factor (BDNF) levels are reduced in individuals suffering major depressive disorder and these levels normalize following antidepressant treatment. Various antidepressants and electroconvulsive therapy are shown to have a positive effect on brain-derived neurotrophic factor levels in depressive patients. The aim of this study was to assess the effect of total sleep deprivation therapy on BDNF levels in major depressive patients. Patients were assigned to two treatment groups which consisted of 22 patients in the sertraline group and 19 patients in the total sleep deprivation plus sertraline group. Patients in the sleep deprivation group were treated with three total sleep deprivations in the first week of their treatment and received sertraline. Patients in sertraline group received only sertraline. BDNF levels were measured in the two treatment groups at baseline, 7th. 14th, and 42nd days. Patients were also evaluated using the Hamilton Rating Scale for Depression (HAM-D). A control group, consisting of 33 healthy volunteers had total sleep deprivation, BDNF levels and depression measured at baseline and after the total sleep deprivation. Results showed that serum BDNF levels were significantly lower at baseline in both treatment groups compared to controls. Decreased levels of BDNF were also negatively correlated with HAM-D scores. First single sleep deprivation and a series of three sleep deprivations accelerated the treatment response that significantly decreased HAM-D scores and increased BDNF levels. Total sleep deprivation and sertraline therapy is introduced to correlate with the rapid treatment response and BDNF changes in this study. (C) 2009 Elsevier Inc. All rights reserved.Öğe Resting energy expenditure in manic episode(Wiley, 2009) Caliyurt, Okan; Altiay, GundenizWe aimed to assess the resting energy expenditure in bipolar I disorder, manic episode patients. Forty-two bipolar I disorder, manic episode patients that were treated in the inpatient psychiatry clinic of Trakya University Hospital and had met the necessary study criteria were included along with 27 controls. DSM-IV criteria and the Bech-Rafaelsen Mania Rating Scale were used to evaluate patients' diagnosis and severity of the manic episodes. The indirect calorimetry device was used to measure resting energy expenditure values. Resting energy expenditure values of manic patients were found to be higher than those of the controls. Controls showed significant correlations between body mass index and resting energy expenditure, but manic patients did not exhibit similar correlations. There was also no relation between Bech-Rafaelsen Mania Rating Scale scores and resting energy expenditure values in manic patients. We found significantly increased resting energy expenditure values in bipolar I disorder, manic episode patients. These findings suggest a possible clinical use of resting energy expenditure for evaluation of bipolar I disorder manic episode and also suggest resting energy expenditure as a possible biological marker.Öğe Öğe Transient changes in inflammatory and oxidative stress markers with total sleep deprivation(Springer Japan Kk, 2016) Cinar, Rugul Kose; Gorgulu, Yasemin; Caliyurt, Okan; Sonmez, BulentSleep deprivation (SD) is known to modulate inflammatory and oxidative stress markers. How these markers change over the SD period have seldom been studied in healthy young adults. Seventeen healthy young adults with a mean age of 19.8 +/- 1.0 years underwent an experimental protocol consisting of 36 h of total SD. We tested whether the stress response was towards adaptation or a worsening of the response. We analysed blood for gene expression levels of interleukins (IL-1 beta, IL-6, IL-33), tumour necrosis factor-alpha (TNF-alpha), glutathione (GSH), heat-shock protein 70 (HSP70), and a member of the signal transducers and activators of transcription (STAT3) family with quantitative real-time polymerase chain reaction (qRT-PCR). We also measured plasma levels of cortisol and malondialdehyde (MDA) with a spectrophotometer. All measurements were made at baseline and at the 24th and 36th hour of the study. IL-1 beta, IL-6, and GSH gene expression levels were up-regulated at the 24th hour and down-regulated at the 36th hour (p < 0.05 for all). IL-33 gene expression levels showed no change at the 24th hour and down-regulation at the 36th hour. TNF-alpha gene expression levels were down-regulated at the 24th hour and up-regulated at the 36th hour. Cortisol levels showed a gradual increase at all the measurement points (p < 0.05 for all). HSP70, MDA, and STAT3 had no significant changes. The present study demonstrated that the hyperactivation of the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) axes shown by the up-regulation of genes seen after a sleepless night is a normal response to acute stress, and by increasing the time spent sleepless, the HPA and SAM axes may return to their normal functioning levels.Öğe Triple Chronotherapy for Bipolar Depression: A Case Report(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2019) Kahyaci Kilic, Evnur; Caliyurt, OkanBipolar disorder (BD) is a chronic disease with recurrent episodes of mania and depression. There is urgent need for rapid, effective, and safe treatments for bipolar depression which is difficult to treat using the current standard methods. Triple chronotherapy is a combination of sleep deprivation, sleep phase shift, and bright light therapy which has been shown to induce accelerated and sustained remissions in bipolar depression. In this report, we present a case of bipolar depression undergoing triple chronotherapy in addition to the standard treatment and discuss the importance of getting fast and sustained response in these cases.
