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Öğe 99mTc-MIBI SPET in non-small cell lung cancer in relationship with Pgp and prognosis(Springer, 2002) Yüksel, M; Çermik, TF; Doganay, L; Karlikaya, C; Çakir, E; Salan, A; Berkarda, SHigher technetium-99m methoxyisobutylisonitrile (MIBI) uptake in non-small cell lung cancer (NSCLC) has been reported to be associated with a positive response to chemotherapy. It has previously been found that in tumour cells, P-glycoprotein (Pgp) expression is of importance for tracer uptake. However, some studies have indicated that Pgp expression does not play an important role in Tc-99m-MIBI uptake in NSCLC; indeed, a negative correlation between 99mTc-MIBI uptake and Pgp expression has been reported. Against the background of conflicting results, our aim was to evaluate the relationship between Tc-99m-MIBI uptake, prognosis and Pgp expression in NSCLC. A total of 37 patients with NSCLC underwent Tc-99m-MIBI single-photon emission tomography (SPET) before chemotherapy. In 19 patients both Pgp and p53 expression, and in two patients only p53 expression (due to the limited biopsy material), were measured with immunohistochemical staining. Tc-99m-MIBI uptake was significantly higher in responders than in non-responders: 3.09+/-1.14 vs 2.24+/-0.88 (P<0.03) and 3.09+/-1.08 vs 2.37+/-1.06 (P<0.05) for the early ratio (ER) and the delayed ratio (DR), respectively. The wash-out rate (WR) of responders was not significantly different from that of non-responders. We found no significant differences in ER, DR and WR among the groups positive or negative for Pgp and p53 status. There was a significant positive correlation between the survival rate and both ER and DR: r=0.49 (P=0.003) and r=0.40 (P=0.018), respectively. Patients with ER and DR values above 3 showed significantly longer survival than those with values below 3: 14.7+/-8.5 months vs 7.3+/-5.1 months (P<0.009) and 13.2+/-8.4 months vs 7.4+/-5.3 months (P<0.04) for ER and DR, respectively. However, interestingly, and in contrast to expectations, patients with a Pgp score of +2 showed significantly longer survival (12.9+/-6.7 months) than those with Pgp scores of +1 (4.4+/-3.0 months) or - (negative) (3.8+/-2.2 months) (P<0.009 and P<0.02, respectively). Our results suggest that in NSCLC, patients with higher Tc-99m-MIBI uptake tend to show a positive response to chemotherapy, and patients with ER and DR values above 3 have a significantly better prognosis. We also found that Pgp expression seems to play only a minor role in Tc-99m-MIBI uptake. Our finding that patients with ER and DR values above 3 have a better prognosis needs to be confirmed in larger series of patient.Öğe Accumulation of Tc-99m HIG in brucellosis(Lippincott Williams & Wilkins, 1998) Sarikaya, A; Cermik, TF; Otkun, M; Ogutlu, A; Pekindil, G; Berkarda, S[Abstract Not Available]Öğe Assessment of Tc-99m sestamibi tumor tissue uptake under the influence of increased arterial oxygen saturation(Elsevier Science Inc, 2005) Cermik, TF; Altiay, G; Firat, MF; Hatipoglu, ON; Berkarda, SThe aim of this study is to investigate the potential effect of increased arterial saturation of oxygen in the magnitude of technetium-99m-hexakis-isobutyl-isonitrile ((99)mTc-MIBI) uptake in tumor tissue and to compare the results with those of conventional Tc-99m-MIBI tumor imaging in the same patient with lung cancer. A total of 26 lung cancer patients underwent initial SPECT (I-SPECT) and after oxygen inhalation SPECT (O-2-SPECT). The early (ER) and delayed ratios (DR) Of O-2-SPECT mean +/- S.D. were significantly higher than those of I-SPECT mean +/- S.D. (2.07 +/- 0.57 vs. 1.90 +/- 0.48 and 2.02 +/- 0.45 vs. 1.83 +/- 0.39, respectively). There are increased rates for the relative tumor uptake of Tc-99m-MIBI by 9% for ER and 10% for DR on the O-2-SPECT compared to I-SPECT. We found that 99mTc-MIBI uptake increased significantly in the tumor tissue with O-2-SPECT compared to I-SPECT. In conclusion, 99mTc-MIBI scintigraphy is one of the main methods for differentiating viable and nonviable tissue fractions in tumors. We consider that 99mTc-MIBI uptake increase after oxygen inhalation is an indicator of positive acute cellular response of the tumor tissue to the rising tissue oxygen level. (c) 2005 Elsevier Inc. All rights reserved.Öğe Assessment of tissue viability after frostbite injury by technetium-99m-sestamibi scintigraphy in an experimental rabbit model(Springer Verlag, 2000) Sarikaya, I; Aygit, AC; Candan, L; Sarikaya, A; Türkyilmaz, M; Berkarda, SFrostbite causes injury to the tissue by direct ice-crystal formation at the cellular level with cellular dehydration and microvascular occlusion. Muscle that initially appears viable on reperfusion may subsequently become necrotic because of microcirculatory collapse. Since muscle is a sensitive tissue in frostbite injury, we used technetium-99m-sestamibi limb scintigraphy to assess tissue viability in an experimental rabbit model. Twelve rabbits were used for this investigation. The right hind limb of the rabbits was immersed to the ankle joint in a container filled with 90% ethanol at -25 degrees C for 10 min. Frostbitten limbs were allowed to thaw in air at room temperature. Imaging and pathological examination of the affected limbs were performed 2 h, 24 h, 48 h and 72 h after freezing. In 2-h images, initial hypoperfusion was seen that corresponded to circulatory collapse. In 24-h images, there was hyperperfusion (so-called period of temporary reperfusion), corresponding to circulatory restoration. In 48-h images, a second hypoperfusion corresponded to viable but ischaemic tissue. In 72-h images, there was non-perfusion of the limb that correlated with the pathologically determined diagnosis of necrosis. All scintigraphic patterns correlated with pathological findings. We suggest that these scintigraphic patterns in soft tissue may be helpful in distinguishing between frank infarction and reversible ischemia and therefore may be useful in selecting early therapeutic or surgical interventions to salvage bone and soft tissue. Further studies ape needed to show the usefulness of Tc-99m sestamibi scintigraphy in clinical frostbite cases.Öğe Bone metastasis from primary splenic angiosarcoma to the sacrum demonstrated by Tc-99m-labeled red blood cell and Tc-99m MDP bone scintigraphy(Lippincott Williams & Wilkins, 2001) Çermik, TF; Yüksel, M; Demir, M; Özyilmaz, F; Kaya, M; Vural, Ö; Berkarda, S[Abstract Not Available]Öğe Brain SPECT study in the children with ataxic and choreoathetoid cerebral palsy(Springer Verlag, 1999) Kaya, M; Sarikaya, A; Karasalihoglu, S; Altun-Durmus, G; Üstün, F; Berkarda, S[Abstract Not Available]Öğe The bronchoalveolar epithelial permeability in house painters as determined by Tc-99m DTPA aerosol scintigraphy(Springer, 2003) Kaya, M; Salan, A; Tabakoglu, E; Aydogdu, N; Berkarda, SPurpose: Isocyanates are highly reactive chemicals used in a number of industries including paints. Therefore, house painters are known to be at risk for occupational exposure to isocyanates. Our objectives in this study were: (1) to investigate the possible effects of isocyanate exposition on the bronchoalveolar epithelial permeability in house painters by using Tc-99m DTPA radioaerosol lung scintigraphy; (2) to assess whether or not some differences exist between asthmatic and non-asthmatic house painters, and (3) to determine the relationship between Tc-99m DTPA radioaerosol lung scintigraphy and the spirometric measurements, and the work duration of house painters. Materials and Methods: Ten non-smoking house painters (28.8 +/- 8.8 yrs) and ten healthy volunteers underwent Tc-99m DTPA radioaerosol lung scintigraphy. Following inhalation of radiotracer through a nebulizer for 5 minutes, dynamic scintigrams (1 frame/min, up to 10 min) were taken from both lungs. ROI's were drawn over the both lung area, and time-activity curves were obtained, from which the half-time (T-1/2) of Tc-99m DTPA clearance was calculated. Spirometric lung function test was measured in all house painters. Results: Mean T1/2 values (min +/- SD) were 93.74 +/- 32.79 for house painters, and 90.96 +/- 40.02 for control subjects. There was no significant difference in T1/2 values of Tc-99m DTPA clearance between house painters and controls, and between asthmatic and non-asthmatic house painters as well. No correlation was observed between Tin values of Tc-99m DTPA clearance and spirometric measurements. In house painters, there was a positive correlation between T1/2 values of Tc-99m DTPA clearance and work duration (r = 0.73, p = 0.016). Conclusions: Our findings indicate that in house painters, occupational exposure to isocyanates has no effect on bronchoalveolar epithelial permeability, and the rate of Tc-99m DTPA clearance shows no difference between asthmatic and non-asthmatic house painters. The positive correlation between the rate of Tc-99m DTPA clearance and work duration needs to be confirmed in larger cohorts.Öğe A case of acute tubular necrosis with intestinal visualization of Tc-99m DMSA(Lippincott Williams & Wilkins, 2000) Yüksel, M; Üstün, F; Salan, A; Sen, S; Berkarda, S[Abstract Not Available]Öğe Comparison between semiquantitative interictal Tc-99m HMPAO SPECT and clinical parameters in children with partial seizures(Elsevier Science Bv, 1999) Sarikaya, A; Kaya, M; Karasalihoglu, S; Alemdar, A; Altun, G; Berkarda, SThe aim of the present study was to correlate between clinical parameters (age, age of onset, frequency and durationof seizures) and semiquantitative interictal SPECT parameters in children with partial seizures. We obtained 30 patients who had hypoperfusion in interictal SPECT, retrospectively. All patients underwent a detailed clinical examination, electroencephalography (EEG) investigation and brain computerized tomography (CT) and/or magnetic resonance imaging (MRI). Single photon emission computerized tomography (SPECT) studies were evaluated visually and by calculating semiquantitative parameters (the degree (asymmetry index, Al) and extent (number of ROI) of hypoperfusion). Visual analysis detected ipsilateral hypoperfusion in 23 (76%) patients with a unilateral focus and contralateral hypoperfusion in seven patients. We found an inverse correlation between the age at onset of seizure (r = -0.40, P = 0.025), frequency of seizures(but positive correlation; r = 0.77, P = 0.000) and AI. Number of ROIs showed a moderate correlation with the frequency of seizures (r = 0.67, P = 0.000), while correlation of the age at onset of seizures was not significant. This study per-formed in pediatric patients also suggested that either SPECT parameters may be used for correlating with clinical parameters. (C) 1999 Elsevier Science B.V. All rights reserved.Öğe Comparison of Tc99m MIBI lung and liver uptakes during dipyridamole stress test with or without aminophylline(Springer Verlag, 1999) Yüksel, M; Durmus-Altun, G; Altun, A; Berkarda, S[Abstract Not Available]Öğe Comparison of the protective effects of dimethylsulphoxide and methylprednisolone against the warm ischemia on liver parenchima using hepatobiliary scintigraphy(Springer-Verlag, 2001) Yüksel, M; Hatipoglu, AR; Terniz, E; Saihoglu, YS; Berkarda, S; Yigitbas, ON[Abstract Not Available]Öğe Determination of scintigraphic parameters in normal population according to age and gender by using quantitative salivary gland scintigraphy summary(Springer, 2004) Firat, MF; Sarikaya, A; Cermik, TF; Berkarda, S[Abstract Not Available]Öğe Diffuse uptake of Tc-99m tin colloid in extramedullary Hematopoiesis of the lungs(Lippincott Williams & Wilkins, 2003) Çermik, TF; Turgut, B; Gultekin, A; Çakir, B; Berkarda, S[Abstract Not Available]Öğe Evaluation of dysthymic disorder with technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography(Springer, 1999) Sarikaya, A; Karasin, E; Çermik, TF; Abay, E; Berkarda, SDysthymic disorder is a chronic disorder characterised by the presence of a depressed mood and is classified as a distinct category in DSM-IV, separately from major depression. Although brain imaging studies have been performed in major depressive disease, there have to date been no reports of such studies in dysthymic disorder. In this study 36 patients with dysthymic disorder were compared with 16 normal subjects using technetium-99m hexamethylpropylene amine oxime brain single-photon emission tomography. A relative blood now ratio was calculated for each region of interest using the average tissue activity in the region divided by activity in the cerebellum. There were significant differences in the bilateral inferior frontal, bilateral parietal, right superior frontal and left posterior temporal regions in the patients with dysthymic disorder compared with the healthy controls. These findings support the hypothesis that the biological bases for dysthymic disorder and major depression are similar. Recognition of these regional abnormalities may have clinical utility in both the diagnosis and the treatment of dysthymic disorder. Further studies are needed to confirm our results and to assess the influence of treatment in patients with dysthymic disorder.Öğe Evaluation of liver parenchimal damage after pringle manoeuvre and protective effect of DMSO using hepatobiliary scintigraphy(Springer Verlag, 1999) Yüksel, M; Hatipoglu, A; Temiz, E; Salihoglu, YS; Hüseyinova, G; Berkarda, S[Abstract Not Available]Öğe Evaluation of morphine effect on tumour angiogenesis in mice breast tumour by using 99mTc-Tetrofosmin scintigraphy(Springer, 2004) Ustun, F; Durmus-Altun, G; Tuncbilek, N; Altaner, S; Uzal, MC; Berkarda, S[Abstract Not Available]Öğe Evaluation of skeletal muscle metabolism and erythropoietin treatment response in patients with chronic renal failure with 99mTc-sestamibi leg scintigraphy(Springer Verlag, 1999) Sarikaya, A; Sen, S; Çermik, TF; Birtane, M; Berkarda, S[Abstract Not Available]Öğe Evaluation of skeletal muscle metabolism and response to erythropoietin treatment in patients with chronic renal failure using 99Tcm-sestamibi leg scintigraphy(Lippincott Williams & Wilkins, 2000) Sarikaya, A; Sen, S; Çermik, TF; Birtane, M; Berkarda, SIt is well known that uraemia affects skeletal muscle metabolism. This has been attributed to a variety of causes, including anaemia, vitamin D, carnitine deficiency and hyperparathyroidism. The aim of this study was to ascertain whether Tc-99(m)-sestamibi leg scintigraphy is useful in the evaluation of skeletal muscle metabolism and the monitoring of treatment response in uraemic myopathy. Forty patients with chronic renal failure and 24 normal controls underwent examination. Fifteen patients with chronic renal failure received erythropoietin treatment. Tc-99(m)-sestamibi leg scintigraphy was performed in all subjects and in 15 patients after therapy. The calf-to-ankle uptake ratio was calculated by semi-quantitative analysis and normalized to lean body mass. The normalized uptake ratios were significantly different between patients and controls. After erythropoietin therapy, there was a significant increase in the normalized uptake ratios compared with pre-therapy. Our results suggest that Tc-99(m)-sestamibi leg scintigraphy is useful in the assessment of muscle metabolic abnormalities and the effect of treatment in uraemic myopathy. ((C) 2000 Lippincott Williams & Wilkins).Öğe Evaluation of the factors effecting uptake of Tc-99m MIBI in hyperparathyroidism(Springer, 2004) Cermik, TF; Puyan, FO; Sezer, A; Firat, MF; Berkarda, S[Abstract Not Available]Öğe I-123 MIBG scintigraphy in the detection of amiodarone induced pulmonary toxicity(Springer-Verlag, 2001) Altun, GD; Altun, A; Salihoglu, YS; Sankaya, A; Özbay, G; Berkarda, S[Abstract Not Available]
