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    Evaluation of Clinical and Laboratory Features of Epstein-Barr Virus-Associated Acute Infectious Mononucleosis in Children
    (Aves Yayincilik, Ibrahim Kara, 2008) Celtik, Coskun; Kuecuekugurluoglu, Yasemin; Balci, Demet Benek; Oener, Naci; Duran, Ridvan; Karasalihoglu, Serap
    Objectives: The various symptoms of infectious mononucleosis associated with Epstein-Barr virus may confuse physicians in differential diagnosis. The aim of this study is to evaluate the clinical and laboratory findings of this disease in symptomatic children. Patients and Methods: This study was retrospectively performed on 52 cases (31 boys, 21 girls; mean age 5.4 +/- 3.4 years; range 1 to 13 years) with acute Epstein-Barr virus infection. The clinical and laboratory findings were evaluated according to admission time after initial complaints (<= 5/>5 days) and the age groups of the cases (<= 2/>2 years). Results: The major symptoms were fever, lymphadenopathy and tonsillopharyngitis in the classical triad. Moreover, atypical cases who had ascites, arthritis and severe abdominal pain were defined. No case had a poor prognosis. The most frequent laboratory finding was lymphocytosis. While the major symptoms were more frequent in the group admission time <= 5 days, the count of atypical lymphocyte were higher in the group admission time > 5 days. However, these differences could not be defined between age groups. Conclusion: Infectious mononucleosis due to Epstein-Barr virus is a disease with good prognosis in children. The features of the disease may vary according to admission time, and this fact should be taken into consideration in the diagnosis.