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Öğe THE ASSOCIATION OF INTRON 4 VNTR AND GLU298ASP POLYMORPHISMS OF THE NITRIC OXIDE SYNTHETASE 3 GENE AND VASCULOGENIC ERECTILE DYSFUNCTION IN TURKISH MEN(Elsevier Sci Ltd, 2020) Arda, E.; Ay, A.; Akdere, H.; Akdeniz, E.[Abstract Not Available]Öğe Correlation between pre-radical prostatectomy Standardized SUVmax ratios detected on 68Ga-PSMA-I&T PET/CT and final histopathology outcomes: An in-depth analysis(Elsevier Espana Slu, 2024) Arikan, M. G.; Soyluoglu, S.; Korkmaz, U.; Tastekin, E.; Elboga, U.; Arda, E.Objective: To evaluate the predictive potential of the maximum standardized uptake value (SUVmax) value of intraprostatic tumors derived from preoperative [Ga- 68 ]Ga-PSMA-I&T PET/CT (SUVT), and its ratios to SUVmax in the liver (SUVTLR) and parotid gland (SUVTPR) with respect to histopathological findings. Materials and methods: Data from patients who underwent radical prostatectomy (RP) for prostate cancer (PC) at our clinic between 2017-2020 were assessed. Patients with a secondary malignancy, a history of transurethral prostate resection, prior treatment for PC, or who received salvage RP were excluded. Whole -body images obtained using the same device, as per the guidelines, were reviewed by two nuclear medicine specialists with more than a decade of experience to reach a consensus for each lesion. The relationships between age, PSA, Prostate Volume, clinical T stage, biopsy International Society of Urological Pathology grade (ISUP), D'amico risk group, intraprostatic tumor volume (HPTV) identified in the final histopathological specimen review, HP-ISUP grade, seminal vesicle invasion (SVI), extracapsular invasion (ECI), positive surgical margine (PSM), SUVT, SUVTLR, and SUVTPR were analyzed. Results: The mean age of the 64 included patients was 64.1 +/- 5.3 y -o. A statistically significant correlation was found between SUVT, SUVTLR, SUVTPR values, and histopathologic stage parameters, such as biopsy ISUP, D'amico Risk Classification, HP-ISUP, HPTV ( P <.05). PSMATV, SUVT, and SUVTLR were statistically significant predictors of extracapsular invasion, while PSA, PSMATV, and SUVTLR were significant predictors of SVI ( P <.05). Conclusion: The standardized SUVT, SUVTLR, and SUVTPR values could be employed as noninvasive markers to assist in predicting postoperative histopathological findings, particularly ECI, SVI, and PSM.Öğe GENDER REASSIGNMENT SURGERY: PRELIMINARY OUTCOMES OF THE TRAKYA UNIVERSITY HEALTH CENTER FOR MEDICAL RESEARCH AND PRACTICE(Elsevier Sci Ltd, 2019) Arda, E.; Top, H.[Abstract Not Available]Öğe Histopathological and biochemical comparisons of the protective effects of amifostine and L-carnitine against radiation-induced acute testicular toxicity in rats(Wiley, 2017) Aktoz, T.; Caloglu, M.; Yurut-Caloglu, V.; Yalcin, O.; Aydogdu, N.; Nurlu, D.; Arda, E.The aim of this study was to compare the radioprotective efficacies of amifostine (AMI) and L-carnitine (LC) against radiation-induced acute testicular damage. Thirty Wistar albino rats were randomly assigned to four groups: control (n = 6), AMI plus radiotherapy (RT) (n = 8), LC plus RT (n = 8) and RT group (n = 8). The rats were irradiated with a single dose of 20 Gy to the scrotal field. LC (300 mg/kg) and AMI (200 mg/kg) were given intraperitoneally 30 min before irradiation. The mean seminiferous tubule diameters (MSTDs) were calculated. Testicular damage was evaluated histopathologically using Johnsen's mean testicular biopsy score criteria. Malondialdehyde (MDA) and glutathione levels were measured in tissue samples. AMI plus RT and LC plus RT groups had significantly higher MSTDs than those in the RT group (p =.003 and p =.032 respectively). MDA values of both AMI plus RT and LC plus RT groups were significantly lower than those in RT group (p <.004 and p <.012 respectively). As a result, AMI and LC have a similar radioprotective effect against radiation-induced acute testicular damage, histopathologically and biochemically.Öğe PROTECTIVE EFFECTS OF AMIFOSTINE AND L-CARNITINE AGAINST RADIATION INDUCED ACUTE TESTICULAR TOXICITY(Elsevier Ireland Ltd, 2012) Caloglu, M.; Aktoz, T.; Caloglu, V. Yurut; Yalcin, O.; Aydogdu, N.; Nurlu, D.; Arda, E.[Abstract Not Available]Öğe Radiation-induced acute kidney toxicity: Protective effect of L-carnitine versus amifostine(Ijrr-Iranian Journal Radiation Res, 2015) Yurut-Caloglu, V.; Caloglu, M.; Deniz-Yalta, T.; Aktoz, T.; Nurlu, D.; Kilic-Durankus, N.; Arda, E.Background: The aim of the study was to compare the radioprotective efficacy in the kidney of L-carnitine to that of amifostine. Materials and Methods: Thirty three-month-old Wistar albino rats were randomly assigned to four groups: Group 1 (Control); Group 2 (Irradiation alone); Group 3 (amifostine plus irradiation); and Group 4 (L-carnitine before irradiation). The rats in Groups 2, 3, and 4 were irradiated individually with a single dose of 20 Gy to whole abdomen. L-carnitine (300 mg/kg) or amifostine (200 mg/kg) was administered 30 minutes before irradiation. Euthanasia was performed 5 days after irradiation, and kidneys were evaluated histopathologically. Results: Dilatation of Bowman's capsule, congestion of blood vessels, and tubular epithelial degeneration were significantly different among the groups (p < 0.05). Pretreatment with both L-carnitine and amifostine reduced the radiation-induced dilatation of Bowman's capsule (p < 0.05), congestion of blood vessels (p < 0.05), and tubular epithelial degeneration (p < 0.05). L-carnitine and amifostine were similar in protective effect. Conclusion: L-carnitine was equally effective as amifostine in protecting the kidney against acute irradiation damage.Öğe TRANSGENDER BOTTOM SURGERY: OUTCOME AND COMPLICATION EXPERIENCE OF A SINGLE CENTER FROM TURKEY(Elsevier Sci Ltd, 2020) Arda, E.; Top, H.[Abstract Not Available]