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Öğe Aspergillus spp. isolations from respiratory tract samples in Trakya University Hospital(Turkish Assoc Tuberculosis & Thorax, 2007) Gurcan, Saban; Demir, Muzaffer; Altiay, Gundeniz; Tikvesli, Melek; Kilic, Haluk; Otkun, MetinThe characteristics of cases diagnosed as aspergillosis and Aspergillus spp. strains isolated from the respiratory tract samples in Mycology Laboratory of Trakya University Hospital between January 2002 and May 2006 were investigated. In this period, 137 bronchoalveolar lavages, 95 sputum, nine tracheal aspirates, three lung biopsies and one bronchial biopsy of 85 patients were processed. The samples were incubated in 25 degrees C and 35 degrees C media by culturing on brain heart infusion agar with blood and Sabouraud dextrose agar. Presence of leucocytes and fungal structures were searched in the smear stained by Gram and Giemsa. The patient was defined as probable aspergillosis case, if he/she patient had clinical findings, lung infiltration or fungus ball radiologically, at least one risk factor predisposing to aspergillosis and isolation of Aspergillus spp. in lower respiratory tract samples without finding of other nonmycotic infection. Of 22 patients isolated Aspergillus spp., 13, six, two, one were internalized in chest diseases, haemotology, neurosurgery and oncology clinics, respectively. Seven positive cultures were considered as findings of aspergillosis. Aspergillus fumigatus, Aspergillus flavus and Aspergillus niger were isolated in three, two, and two patients, respectively. Fungal structures were detected in only one sample in the direct microscopical examination. Ages of seven patients, five were males and two were females, were between 15 and 60. Predisposing risk factors were acute leukemia in six patients and lung cancer in one patient. Five patients were neutropenic and one was neutrophylic. Fungus ball was detected in radiological imaging of one patient, had a pulmonary cavitary lesion. Conventional amphotericine B was used in their therapies. Antifungal agents were switched to caspofungin and itraconazole in two and one patients, respectively. Three patients died in four weeks after isolation of Aspergillus spp. Aspergillosis cases were not high in our hospital because of absence of transplantation center for bone marrow or solid organ.Öğe Bronchiolitis Obliterans Organizing Pneumonia: Three Cases Leading to Respiratory Failure(Bilimsel Tip Publishing House, 2005) Altiay, Gundeniz; Hatipoglu, Osman Nuri; Tabakoglu, Erhan; Yalcin, Omer; Caglar, TuncayBronchiolitis obliterans organizing pneumonia (BOOP) is an entity of unknown etiology characterized histologically by granulation tissue plugs within the lumens of small airways extending into the alveolar ducts and airways. The typical presenting symptoms and signs are dyspnea, cough, fever, weight loss, and a chest radiograph with single or multiple alveolar opacities. Some cases progress rapidly and have a poor prognosis. We followed-up three idiopathic BOOP cases in one month. Pathological diagnosis was based on transbronchial lung biopsy (TBLB) in all of them. The characteristic features of all cases were progressive respiratory failure. We treated them with high dose prednisolone for three days (first day 80 mg q6h, second day 80 mg q8h, third day 80 mg q12h) and continued with 1 mg/kg/d prednisolone. We observed rapid radiological and clinical improvement in all cases. Interestingly, these three patients were admitted to our clinic with progressive respiratory failure in the same one month period.Öğe A case of ruptured hydatid cyst with upper lobe localization that imitated active lung tuberculosis(Aves Yayincilik, Ibrahim Kara, 2007) Ozlen, Burcu; Ozdemir, Levent; Yoruk, Yener; Altiay, Gundeniz; Tabakoglu, Erhan; Hatipoglu, Osman NuriHydatid cyst is a parasitic infestation caused by Echinococcus granulosus. Although liver is the most common site of infection, lungs may also be affected in 10 to 30 % of cases. The cyst is usually located in the lower lobes. of the lungs. A 49-year-old male patient with a cavitary lesion in the posterior segment of the right upper lobe, was admitted to the tuberculosis ward with a preliminary diagnosis of lung tuberculosis (TB), and anti-TB treatment was started empirically. Bronchoscopy was performed after three different sputum examinations with negative results for acid-fast bacilli (AFB). Bronchoalveolar lavage examination was also negative for AFB. High resolution computed tomography showed findings of a ruptured hydatid cyst, rather than TB. A cysctotomy was performed to the patient whose indirect hemagglutination test result was negative for hydatid cyst.Öğe Cisplatin-Dependent Nephrotoxicity in Patients with Lung Cancer(Kare Publ, 2016) Ozdemir, Burcu; Ozdemir, Levent; Hatipoglu, Osman; Tabakoglu, Erhan; Altiay, GundenizOBJECTIVE The aim of the present study was to investigate nephrotoxicity development ratios and clinical results of nephrotoxicity in patients diagnosed with lung cancer who received cisplatin in chemotherapy protocol. METHODS A total of 170 lung cancer patients were enrolled in the present prospective study. Renal functions were recorded for each patient before and after chemotherapy. Nephrotoxicity was defined as doubling in plasma creatinine concentration. Modification in treatment due to nephrotoxicity (reduction in cisplatin dosage, cisplatin interruption, or discontinuation of chemotherapy) was recorded during chemotherapy courses. RESULTS Decreasement of creatinine clearance levels was observed following each course of chemotherapy, but was especially noteworthy following the 1st and 5th courses (p=0.002; p=0.007, respectively). Nephrotoxicity was observed in 19 of the 170 patients (11%), in 10 of whom (53%) cisplatin dosage was reduced, and in 8 of whom (42%), cisplatin treatment was interrupted. Chemotherapy was discontinued in 1 patient (5%). CONCLUSION Particularly following the fourth course, chemotherapy must be carefully administered due to risk of nephrotoxicity.Öğe Cognitive dysfunction in patients with chronic obstructive pulmonary disease(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2018) Pekel, Nilufer Buyukkoyuncu; Turgut, Nilda; Altiay, Gundeniz; Demir, Muzaffer; Turgut, Burhan; Erbas, Hakan; Sut, NecdetObjective: Chronic obstructive pulmonary disease (COPD) is characterized with air flow limitation. Cognitive problems can appear in advanced stage of COPD. There is relationship between COPD and levels of homocystein (hcy) and total antioxidant capacity (TAC). There is also relationship between cognitive dysfunction and levels of hcy and TAC. We aimed evaluation of cognitive functions in patients with COPD, and demonstration of the relationship between cognitive function and hcy and TAC. Methods: Twenty-eight hypoxic (group 1), 28 non-hypoxic COPD patients (group 2) and 25 healthy people (control group, group 3) were included to study. Hcy and TAC levels were measured in all subjects. Cognitive functions were evaluated in all subjects with standardized mini mental test (SMMT), clock drawing test (CDT), Blessed orientation memory concentration test (BOMCT), Benton's facial recognition test (BFRT) and clinical dementia rating scale (CDRS). Results: Hcy levels were high in group 1 (p=0.004), TAC levels were high in group 1 and 2 (p=0.04). SMMT (p=0.000) and CDT values were low in group1 (p=0.000), CDRS values were high in group1 and 2 (p=0.000), BFRT values were low in group1 and 2 (p=0.000), BOMCT values were high in group1 (p=0.000). There were a correlation between TAC and SMMT (r=0.582, p=0.001) and CDRS (r=-0.384, p=0.044). Conclusions: We demonstrated presence of cognitive dysfunction in COPD patients. Patients with hypoxic had more profound cognitive dysfunction. In addition, we demonstrated a relationship between TAC and cognitive dysfunction.Öğe The Effect of Acute Total Sleep Deprivation on Energy Metabolism(Aves, 2011) Caliyurt, Okan; Edis, Ebru Cakir; Altiay, GundenizObjective: The aim of the present study was to assess the effects of total sleep deprivation on daily basal energy expenditure. Methods: Twenty healthy volunteers were included in the study. Resting energy expenditure was measured with indirect calorimetry device (Vmax 29c Sensor Medics, Yorba Linda, CA, USA) at 09: 00 a. m., and food was withheld after midnight the prior evening. The measurements were carried out after eight hours of rest in awake subjects at constant ambient (environmental) temperature for at least 20 minutes. After 24 hours of total sleep deprivation, the measurements were repeated. Results: The first-measured mean resting energy expenditure was 1351.10+/-600.37 kcal/24 h and the second measurement revealed slight decrease with a mean value of 1250.60+/-454.39 kcal/24 h, but the difference did not reach the level of statistical significance. The changes in mean resting energy expenditure values before and after total sleep deprivation were evaluated in men and women separately, but no significant difference was observed between the two genders. Mean body mass index values correlated positively and significantly with both first and second resting energy measurements. Conclusion: Our results showed that total sleep deprivation did not directly affect daily basal energy expenditure. Sleep deprivation, sleep disorders and insomnia are associated with metabolic changes. Those metabolic effects are more likely related to chronic sleep restriction and changes in appetite and glucose metabolism that may cause weight gain and diabetes, rather than being direct effects on energy expenditure. (Archives of Neuropsychiatry 2011; 48: 17-21)Öğe The Effect of Cisplatin plus Etoposide Therapy on Serum Total and Lipid-Bound Sialic Acid Levels in Patients with Non-small Cell Lung Cancer(Turkish Biochem Soc, 2010) Gokmen, Selma Suer; Kazezoglu, Cemal; Tabakoglu, Erhan; Gungor, Ozgul; Altiay, Gundeniz; Ture, MevlutObjectives: To investigate the effect of cisplatin+etoposide therapy on serum total and lipid-bound sialic acid levels in patients with non-small cell lung cancer and evaluate the role of these parameters in the monitoring of the therapy. Patients and Methods: To 18 patients (all men) who are newly diagnosed as nonsmall cell lung cancer, cisplatin was given intravenously (80mg/m(2)) on day 1 and etoposide was given (100mg/m(2)) on day 1-3 to the patients once at an interval of 21 day. Blood samples before the first chemotherapy were compared with those obtained after the second and third chemotherapy. The percent of chemotherapy responses of patients were also calculated. Total and lipid-bound sialic levels were determined by the methods of Warren and Katopodis, respectively. Results: There was a significant decrease in serum lipid-bound sialic acid levels after the second chemotherapy when compared with those before the first chemotherapy (t=2.216, p=0.041). Positive response to cisplatin+etoposide therapy was observed in 88.89% (11.11% of total response, 44.44% of partial response and 33.33% of stable response) of the patients. Progressive disease was established in only 11.11% of the patients. It was found a statistically significant decrease in both serum total (t=2.924, p=0.017) and lipid-bound sialic acid (t=3.635, p=0.005) levels after the third chemotherapy when compared with those before the first chemotherapy. Conclusion: Determination of serum total and lipid-bound sialic acid levels besides routine applications may be useful in the monitoring of cisplatin+etoposide therapy.Öğe THE EFFECT OF WARFARIN ON SURVIVAL IN PATIENTS WITH LUNG CANCER(Lippincott Williams & Wilkins, 2012) Ciftci, Abdullah; Altiay, Gundeniz[Abstract Not Available]Öğe Effecting factors on survival in patients taking thrombolytic treatment due to massive pulmonary embolism(Turkish Assoc Tuberculosis & Thorax, 2010) Hatipoglu, Osman Nuri; Perincek, Gokhan; Edis, Ebru Cakir; Tabakoglu, Erhan; Altiay, GundenizMassive pulmonary embolism (MPE) is a life threatening disease, thrombolytic treatment could save lives. The aims of this study are to identify early and late mortality rates in patients with MPE who received thrombolytic treatment, and mortality related risk factors. All the hospital records for the MPE patients who received thrombolytic treatment between 1998 and 2006 were retrospectively investigated. Pulmonary embolism was diagnosed through computed tomografi scan and V/P scintigraphy. Due to MPE, 21 women total 41 patients who undergo tPA or streptokinase were included in the study. Kaplan-Meier for the survival analysis and cox regression analysis for determining the mortality related independent risk factors were used. Dying while staying in hospital was accepted as early or hospital mortality, after discharge from hospital as late mortality. Out of 41 patients, 12 of them died while they are hospitalized (hospital mortality; 29%) 6 of them died after they were discharged (late mortality; 21%). The average survival time among discharged patients was 2304 days (95% confidence interval: 1725-2884). Among those patients who took streptokinase or tPA, late or early mortality rates (p>0.05) and survival time did not show significant difference (p=0.8908). The presence of arrhythmia [p=0.01; odds rate (OR): 6.25] and jugular vein distention (JVD) (p=0.03; OR: 6.25) for hospital mortality and multiple ongoing health problems for the late mortality were identified as the independent risk factors. For the hospital mortality, the presence of JVD or arrhythmia, for prognostic sensitivity, specificity, positive predictive value and negative predictive value were recorded as 75%, 79%, 60% and 88% respectively. In conclusion, the presence of arrhythmia and/or JVD on a patient with MPE is a negative prognostic factor for hospital mortality. The presence of other ongoing health problems influences the survival time of the discharged patients.Öğe The Efficacy of Flutter® and Active Cycle of Breathing Techniques in Patients with Bronchiectasis: A Prospective, Randomized, Comparative Study(Bilimsel Tip Publishing House, 2018) Uzmezoglu, Bilge; Altiay, Gundeniz; Ozdemir, Levent; Tuna, Hakan; Sut, NecdetOBJECTIVES: The objective of the study was to compare the efficacy of an oscillating positive expiratory device and the active cycle of breathing techniques (ACBT) in patients with bronchiectasis. MATERIALS AND METHODS: A home-based study that lasted for 4 weeks was designed to compare the oscillating physiotherapy device Flutter (R) and the ACBT in 40 patients, who were randomly assigned into two groups containing 20 patients each. The effect of the two methods of physiotherapy on sputum production, pulmonary functions, and the quality of life was compared. RESULTS: The results of the present study indicate that both the methods were associated with a reduced number of patients complaining of cough and fatigue and increased sputum production (p=0.000, p=0.004, and p=0.002, respectively). In addition, statistically significant reductions were determined by the Medical Research Council and Borg Dyspnea scores (p=0.001 and 0.002, respectively). The Flutter (R) device caused a more significant effect on the perception of dyspnea. Overall, there was an improvement in the physical sub-scale of the Short Form (SF)-36 Quality of Life Questionnaire scores of 36 patients who completed the study (p=0.001). During the physiotherapy period, no changes in pulmonary functions were observed. Exacerbations were recorded in 3 patients in the ACBT group and in 1 patient in the Flutter (R) group. CONCLUSION: The Flutter (R) device and ACBT represent effective home-based physiotherapeutic methods. The Flutter (R) device appears to be more effective with regard to sputum production.Öğe Evaluating flutter device and the active cycle of breathing technique in non-cystic bronchiectasis: The prospective randomised study(European Respiratory Soc Journals Ltd, 2012) Altiay, Gundeniz; Uzmezoglu, Bilge; Sut, Necdet; Tuna, Hakan; Hatipoglu, Osman Nuri[Abstract Not Available]Öğe Fat Embolism: Case Report(Aves, 2006) Ozdemir, Levent; Tabakoglu, Erhan; Gurlu, Vuslat; Hatipoglu, Osman Nuri; Altiay, Gundeniz; Yilmam, Ilker; Ozlen, BurcuFat embolism syndrome is a rare disorder which usually may be seen as a complication of long bone trauma. It becomes apparent 24-72 hours after injury with respiratory, neurological, urinary, ocular and cutaneous symptoms and sings. Our case is a 46 years old male patient who evaluated 30 hours after left tibia fracture for confusion, fever, dyspnea, tachypnea and a petechial rash on the anterior chest and anterior axillary folds. Chest radiograph was normal. The patient had hypoxemia and hypocapnia in arterial blood gases measurement. Ventilation perfusion scintigraphy revealed emboli with intermediate probability. No other etiology could be found to explain the state of confusion. Cotton-wool exudates and small haemorrhages were observed in retina. Many fat globules were found in urine samples. After steroid treatment, rapid clinical improvement was observed.Öğe The Influence of the Turkish Anti-Tobacco Law on Primary School Children in Edirne(Galenos Publ House, 2011) Tabakoglu, Erhan; Caglar, Tuncay; Hatipoglu, Osman N.; Altiay, Gundeniz; Edis, Ebru Cakir; Sut, NecdetObjective: The Turkish anti-tobacco law was accepted and effectuated in 1996. All forms of cigarette advertising, the sale of tobacco products to persons under the age of 18 and smoking in public institutions were all restricted. In this paper, we aimed to evaluate the influence of the Turkish anti-tobacco law on children for the periods before the law, after three years and after 10 years. Material and Methods: A self-completed questionnaire was distributed among primary school children. This included questions about the children's smoking habits, their opinions of parents' and teachers' smoking habits, tobacco use in public places and the recognition rate of 16 food, drink, cigarette and toothpaste logos and brand names, The first, second and third applications of the questionnaire were performed with students who attended the same classes in the same primary schools, accounting for 772 children in June 1996, 1,157 children in February 1999 and 719 children in June 2006. Results: When these three periods were evaluated, it could be seen that the prevalence of having smoked significantly decreased (13.9%, 4%, 2.2%, p<0.001), as did the rate of purchasing cigarettes within the past week (36.6%, 29.1%, 15.8%, p<0.001). The disagreement with parents' and teachers' smoking habits and tobacco usage in public places increased significantly (p<0.001), while the recognition rates of some cigarette brand names and logos significantly decreased, specifically with regards to Marlboro, Camel and Samsun (p<0.001). Conclusion: The Turkish anti-tobacco law has had a positive effect on primary school children in Edirne, and therefore could be a model for other countries.Öğe Inguinal lymph node as the only evidence of progressive lung cancer(Soc Portuguesa Pneumologia, 2008) Kocak, Zafer; Saynak, Mert; Oz-Puyan, Fulya; Cicin, Irfan; Cosar-Alas, Rusen; Caloglu, Murat; Altiay, GundenizTumours that metastasise to groin nodes most frequently originate in genital and reproductive organs, skin, rectum or anus, or urinary bladder(1,2). However, rare cases of inguinal metastases from tumours above the diaphragm have been reported and only three of them had an inguinal metastasis which was recognised antemortem and reported in detail in the English medical literature(3-5). The primary tumours of these cases were malignant mesothelioma, salivary duct and breast carcinoma. In this paper, we report a case of carcinoma of the lung metastatic to an inguinal lymph node as the only evidence of progressive lung cancer.Öğe Metachronous primary lung cancers: The importance of a lifelong follow up(Turkish Assoc Tuberculosis & Thorax, 2016) Kocak, Zafer; Hatipoglu, Osman; Okumus, Dilruba; Altiay, Gundeniz[Abstract Not Available]Öğe Mortality Rates and Related Factors in Respiratory Intensive Care Unit Patients(Aves, 2007) Altiay, Gundeniz; Tabakoglu, Erhan; Ozdemir, Levent; Tokuc, Burcu; Cevirme, Leyla; Hatipoglu, Osman Nuri; Caglar, TuncayThe aim of this study is to identify the mortality rates and the influential factors in the respiratory intensive care unit (ICU). We prospectively evaluated a total of 150 patients consecutively admitted with respiratory failure between May 2003 and May 2005 in Trakya University Hospital, and 135 patients were enrolled in the study. The patients excluded from the study were the ones who died within the first 24 hours of ICU (n: 8), or had malignant diseases (n: 7). Chi-square test and t-test were used to compare hospital survivors with non-survivors, and logistic regression analysis was performed to define independent factors influencing the mortality rates in the hospital. To determine the efficiency of APACHE II, ROC analysis was used. 92 of the patients were male and 43 were female. The mean age was 64.9 +/- 12.9 years. The mortality rate was 32.6% (n: 44). The highest mortality rate was in patients with severe pneumonia/sepsis. (54.2%). The main conditions independently associated with increased mortality rate were arrhythmias (odds ratio [OR], 8.10; 95% confidence interval [CI], 2.67-24.58; p < 0.05), the need for invasive mechanical ventilation (OR, 6.04; 95% CI, 1.88 - 19.34; p < 0.05), the need for cardiotonic medication (OR: 5.36; % 95 CI: 1.67 - 17.22, p<0.05) and ventilator-associated pneumonia (OR: 5-21; 95% CI: 1.54-17.63; p < 0.05).Öğe A new clinical model in pulmonary embolism and its correlation with V/P scan results(Sage Publications Inc, 2006) Hatipoglu, Osman N.; Hanci, Emel; Tabakoglu, Erhan; Altiay, Gundeniz; Cermik, Tevfik Fikret; Caglar, TuncayThe study was prospectively designed to assess the correlation between a new clinical model empirically developed for acute pulmonary embolism (PE) and ventilation/perfusion (V/P) scan results. One hundred sixty consecutive patients with suspected acute PE underwent clinical evaluation before V/P scintigraphy. The clinical probability of PE was categorized according to a structured clinical model empirically developed as low, intermediate, or high, and the results were compared with those of V/P scintigraphy. Forty, 61, and 59 patients were classified as low, intermediate, and high clinical probability, respectively. Seventy-five percent (30/40) of the patients with low clinical probability were also of low scintigraphic probability or had a normal result (r(s): 0.39, p=0.000); 28% (17/61) of the patients with intermediate clinical probability demonstrated intermediate scintigraphic probability (r(s): 0.20, p=0.012); and 68% (40/59) of the patients with high clinical probability were also of high scintigraphic probability (r(s): 0.43, p=0.000). Overall, the correlation of two scoring systems was statistically significant (r(s): 0.39, p=0.000). Unilateral leg swelling (p=0.027), syncope or near syncope (p=0.002), amputation of a hilar artery (p=0.007), and electrocardiographic signs of right ventricular overload (p=0.000) prevailed in patients with high scintigraphic probability. Syncope-near syncope or hemodynamic collapse PLUS electrocardiographic signs of right ventricular overload or hypoxemia combination had the most significant correlation with a high scintigraphic probability (r(s): 0.31; p=0.000). In conclusion, the new clinical model empirically developed was significantly successful to provide comparable results with V/P scan. This consistency was particularly prominent in patients with low or high clinical probability for PE.Öğe Prognostic Factors Affecting Survival in Small Cell Lung Cancer Patients(Wolters Kluwer Medknow Publications, 2009) Ozlen, Burcu; Hatipoglu, Osman Nuri; Ozdemir, Levent; Sut, Necdet; Altiay, Gundeniz; Tabakoglu, ErhanAim: Small cell lung cancer (SCLC) is an aggressive tumour with a poor clinical course, but responsive to both chemotherapy and radiotherapy. Some clinical and laboratory parameters can predict survival in SCLC. The aim of this study was to analyze the survival and identify the prognostic factors that influence survival in SCLC. Material andMethod: Forty six consecutive SCLC patients who were planned for chemotherapy, enrolled in this study prospectively. We recorded basic characteristic properties and factors affecting prognosis for each patient. We determined their survival time and survival curves were calculated by the method of Kaplan and Meier analysis. Results: Median survival time was 338 days (95% confidence interval: 243-432). Survival ratio for one month was 89%, for 6 months 62% and for one year 45%. Significiant parameters (p< 0.05) evaluated by univariate analysis followed by multivariate analysis. In multivariate analysis liver metastas (Relative Risk (RR): 4.99, 95% confidence interval: 1,21 -20,53), weight loss (RR: 11.3, 95% confidence interval 1,11-115,5) and low level of total protein after first chemotherapy (RR: 0.198, 95% confidence interval 0,06-0,63) were found as independent factors affecting survival. Conclusion: SCLC is a disease with high mortality. Prognostic factors that we found, can be supported by further investigations.Öğe Relationship Between Pregnancy-Associated Plasma Protein-A and Lung Cancer(Elsevier Science Inc, 2009) Bulut, Ismet; Coskun, Abdurrahman; Ciftci, Abdullah; Cetinkaya, Erdogan; Altiay, Gundeniz; Caglar, Tuncay; Gulcan, ErimBackground: Pregnancy-associated plasma protein-A (PAPP-A) has insulin-like growth factor (IGF)-dependent IGFBP-4 protease activity and plays an important role in amplifying local IGF-1 activity in wound healing, vascular repair. and bone remodeling. We postulated that PAPP-A may contribute to the availability and activity of IGFs, which affect lung cancer. Therefore, we determined the levels of PAPP-A in patients with lung cancer and their possible clinical significance. Methods: The study population consisted of 83 patients with lung cancer and 33 healthy subjects as a control group. Serum PAPP-A levels were determined using an ultrasensitive enzyme-linked immunosorbent assay. Results: The serum PAPP-A levels were higher in patients with lung cancer [median (interquartile range) 10.7 (7.6-14.2) ng/mL] than in the control group [6.2 (5.2-9.8) ng/mL, P < 0.001]. There was a significant negative correlation between the serum PAPP-A levels and Karnofsky performance status (r = -0.330; P < 0.001) and a positive correlation with patient age (r = 0.358; P < 0.001). Conclusion: PAPP-A is a proatherosclerotic metalloproteinase that is also thought to be an inflammatory marker. We found that the serum PAPP-A levels increased in patients with lung cancer and postulated that PAPP-A levels may be a prognostic factor in such cases.Öğe Resting energy expenditure in manic episode(Wiley, 2009) Caliyurt, Okan; Altiay, GundenizWe aimed to assess the resting energy expenditure in bipolar I disorder, manic episode patients. Forty-two bipolar I disorder, manic episode patients that were treated in the inpatient psychiatry clinic of Trakya University Hospital and had met the necessary study criteria were included along with 27 controls. DSM-IV criteria and the Bech-Rafaelsen Mania Rating Scale were used to evaluate patients' diagnosis and severity of the manic episodes. The indirect calorimetry device was used to measure resting energy expenditure values. Resting energy expenditure values of manic patients were found to be higher than those of the controls. Controls showed significant correlations between body mass index and resting energy expenditure, but manic patients did not exhibit similar correlations. There was also no relation between Bech-Rafaelsen Mania Rating Scale scores and resting energy expenditure values in manic patients. We found significantly increased resting energy expenditure values in bipolar I disorder, manic episode patients. These findings suggest a possible clinical use of resting energy expenditure for evaluation of bipolar I disorder manic episode and also suggest resting energy expenditure as a possible biological marker.
