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    Can 68Ga-DOTA Peptides Be Potential Radiotracers for PET Imaging of the Spleen?
    (Soc Nuclear Medicine Inc, 2018) Sarikaya, Ismet; Elgazzar, Abdelhamid H.; Sarikaya, Ali; Alnafisi, Naheel; Alenezi, Saud
    On radionuclide somatostatin receptor imaging studies, the spleen shows high physiologic uptake. Reducing the intensity of the image settings helps to better assess the distribution of radiotracer in the spleen. In our routine studies, we incidentally recognized that Ga-68-DOTANOC PET provides higher-resolution splenic images than In-111-octreotide SPECT. Autoradiography and immunohistochemistry studies have shown that somatostatin receptors are located mainly in the red pulp of the spleen. The distribution of Ga-68-DOTANOC in the spleen appears to correlate with the distribution of red pulp. In this article, we present Ga-68-DOTANOC PET/CT spleen images of our patients.
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    Significance of splenic uptake on somatostatin receptor imaging studies
    (Via Medica, 2018) Sarikaya, Ismet; Sarikaya, Ali; Alnafisi, Naheel; Alenezi, Saud
    Spleen shows a high physiological uptake on radionuclide somatostatin receptor (SSTR) imaging studies. Autoradiography and immunohistochemistry studies showed that SSTRs are mainly located in the red pulp of the spleen. In this review article we will summarize the significance of splenic uptake in SSTR imaging studies and will also present high resolution splenic images of Ga-68 DOTANOC PET in which splenic distribution of the radiotracer appears to be correlating with the distribution of red pulp.