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    The Effects of Micronuclei with Whole Chromosome on Biological Dose Estimation
    (Tubitak Scientific & Technological Research Council Turkey, 2008) Pala, Funda S.; Alkaya, Fadime; Tabakcioglu, Kiymet; Tokatli, Fuesun; Uzal, Cem; Parlar, Sule; Alguenes, Cetin
    The total micronucleus (MN) assay has been used for purposes of biological dosimetry for many years. The variable spontaneous incidence of micronuclei in peripheral blood lymphocytes affects the sensitivity of biological dose estimations at low doses. It has been suggested that this problem could be solved by using the micronuclei-centromere assay. In this study. Co-60 gamma ray dose response curves for micronuclei (MN) and micronuclei without centromeres (MNC-) in the range of 0-5.0 Gy were established using a pancentromeric FISH probe on cultured binucleate lymphocytes from 2 donors. There were no significant inter-donor differences in the dose responses for either MN or MNC-. The relative proportions of MN that contained centromeres (MNC+) decreased with radiation dose, which is in line with the proposition that radiation predominately causes chromosomal breakage rather than whole chromosome loss. The a coefficients of MNC- curves decreased to 62% of the values for total MN whilst the beta coefficients were unchanged. MN and MNC+ frequencies of 60 control smoker and 40 non-smoker donors were also compared. No effect of smoking was observed. However the MNC+ spontaneous frequencies showed an age and gender effect with the highest frequencies in older women.
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    Evaluation of Frequencies of HLA-A, B and DR in Thracian Population and Examination of its Relationship With Balkan Populations
    (Aves Yayincilik, Ibrahim Kara, 2008) Pala, Funda Sibel; Tabakcioglu, Kiymet; Alguenes, Cetin; Oemuerlue, Imran Kurt
    Objectives: In this study, human leukocyte antigen (HLA) allel frequencies of Thracian Turkish population were determined. Study Design: The study group consisted of 105 tissue donors who live in Thrace region of Turkey for three generations and have similar linguistic features. Polymerase chain reaction-sequence-specific primer (PCR-SSP) method was used for genotyping of HLA-A, B and DRB1 alleles. The most frequent HLA alleles were HLA-A*02 (20.5%), HLA-B*35 (22.9%) and HLA-DR*11 (17.6%). Results: Frequencies of HLA alleles show some variations among different populations because of their highly polymorphic gene structure. Determining the distribution of HLA alleles is one of the most preferred genetical approaches for clarifying the relationship between populations. Conclusion: In this study also, HLA-DR allel frequencies were compared in order to determine the relationship between other Turkish populations and Balkan populations. It is observed that Thracian Turkish population has similar HLA-DR distributions with Balkan populations.