Yazar "Aktuglu, Mehmet Burak" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Cox-2 gene polymorphisms in Turkish patients with myelodysplastic syndrome
    (E-Century Publishing Corp, 2016) Ayer, Mesut; Aktuglu, Mehmet Burak; Acik, Hasan; Bireller, Elif Sinem; Velet, Mustafa; Kirkizlar, Onur; Osmanbasoglu, Emre
    Cyclooxygenase-2 gene polymorphisms have been studied and known its role one on cancerogenesis even though there has not yet been any studies myelodysplastic syndrome. We aimed to provide the first data on COX-2 gene polymorphisms in myelodysplastic syndrome. A total of 39 patients with MDS and 50 healthy controls were recruited from undertaken hematology departmentand compared in terms of COX-2-765 G -> C and COX-2-1195 A. G genes. Statistically significant difference was observed between patients with MDS and controls in terms of COX-2-765 G -> C genotype and distribution of alleles and COX-2-765 GG genotype was more frequently found in the MDS group (P<0.001). Moreover, COX-2-765 C+(CC+CG) genotype was found to provide 5.6 times more protection against MDS. In conclusion, our results indicate that polymorphisms of the C allele of the COX-2 gene may provide protection against MDS; however, its predictive value and potential as a marker in oncology remain to be investigated in further trials.
  • Küçük Resim Yok
    Öğe
    The Relationship Between Factor VIII and Coronary Artery Diseases
    (Galenos Yayincilik, 2012) Meral, Cenk Emre; Aktuglu, Mehmet Burak; Hassoy, Hur; Karaali, Zeynep; Alioglu, Taner; Kirkizlar, Onur; Acar, Sencan
    Aim: Cardiovascular diseases are the major cause of morbidity and mortality worldwide. There are some evidences showing a possible role for hemotostatic system in the pathogenesis of atherosclerotic vascular diseases. In our study, we aimed to show the relationship between coronary artery diseases and factor VIII (F VIII). Methods: 60 patients were included in the study. Blood samples for F VIII were taken before and after the standard Bruce treadmill stress test. Patients with positive stress test underwent coronary angiography. Results: The F VIII levels after the treadmill test were statistically significantly high (p: 0.0001) compared to that before the test. A significant difference was determined in favor of female patients both before (p= 0.002) and after (p= 0.009) the treadmill exercise test when F VIII levels were assessed by gender. Conclusion: Since the discovery of the important role of thrombosis in the pathogenesis of atherosclerotic diseases, investigators are working on whether the haemostatic status is the primary risk factor in coronary artery disease (CAD). Our study results, similar to the literature, showed that F VIII levels in women can be helpful in the diagnosis and follow-up of CAD. But as shown in other studies, F VIII levels may increase in an inflammatory state. Therefore, further studies are needed to determine whether CAD is caused by high levels of F VIII or risk factors for CAD cause endothelial damage and, thus, high levels of F VIII are the result of an inflammatory process.