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https://hdl.handle.net/20.500.14551/3694

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Retrospective Analysis of the Impacts of Treatment Regimens on the Progression and Prognosis of Diabetic Retinopathy and Visual Acuity in Trakya University School of Medicine
(Trakya Üniversitesi, 2021) İzzettinoğlu, Mustafa Ömer; Garip, Rüveyde
Aims: To retrospectively analyze the impacts of treatment regimens on progression and prognosis of diabetic retinopathy and visual acuity in Trakya University Hospital. Methods: This retrospective cross-sectional study was conducted with patients who were diagnosed with diabetic retinopathy in the Ophthalmology Department of Trakya University Hospital between January 2006 and January 2020. Results: Initially, 798 eyes from 399 patients diagnosed with diabetic reti- nopathy met the inclusion criteria. Non-proliferative diabetic retinopathy was present on 202 (50.6%) patients, and 197 (49.4%) patients had proliferative diabet- ic retinopathy. Twenty-five patients (6.2%) had proliferative diabetic retinopathy progression. Patients with proliferative diabetic retinopathy progression had no difference in terms of cataract surgery, gender, and hypertension existence than the ones who did not experience proliferative diabetic retinopathy progression. There was no relation between stability, increase or decrease of visual acuity, the type of diabetes, retinal laser photocoagulation treatment, and the type of in- travitreal injection. Conclusion: Our study showed that retinal laser photocoagulation treatment and cataract surgery had no significant impact on visual acuity prognosis, unlike the initial examination visual acuity values. Additionally, it was also shown that the different types of intravitreal injections made no dissimilar results on visual acuities. In addition, in our study, it was revealed that gender, presence of hypertension, and cataract surgery may not have a significant relation with proliferative diabetic retinopathy progression. Further studies are needed to thoroughly reveal the relation between the treatment regimens, progression, and prognosis of the disease.
Long-Term Surgical Outcomes of Patients With Phacomorphic Glaucoma
(Trakya Üniversitesi, 2021) İzzettinoğlu, Mustafa Ömer; Küpeli Çınar, Ayşe; Garip, Rüveyde
Aims: To retrospectively analyze clinical characteristics of patients diagnosed with phacomorphic glaucoma in the Ophthalmology Department of Trakya University Hospital. Methods: This retrospective cross-sectional study was conducted with patients who were diagnosed with phacomorphic glaucoma in the Ophthalmology Department of Trakya University Hospital between January 2010 and January 2021. Results: Initially, 19 eyes from 19 patients diagnosed with phacomorphic glaucoma met the inclusion criteria. The mean preoperative best-corrected visual acuity was 0.1 ± 0.3 Snellen visual acuity (ranging from 0.001 to 1.0 Snellen visual acuity). A statistically significant increase in postoperative best-corrected visual acuity during the follow-ups has been observed. In terms of intraocular pressure levels, patients had mean preoperative 32.3 ± 11.2 mmHg (range:15-55 mmHg). The decrease in postoperative intraocular pressure levels during follow-ups was statistically significant. Conclusion: Lens removal through phacoemulsification or intracapsular cataract extraction is an effective and safe procedure in the treatment of phacomorphic glaucoma, ensuring a satisfactory long-term intraocular pressure control and a rapid functional recovery. However, most of the patients are expected to have an outcome of favorable best-corrected visual acuity after surgery in the long term.
Clinical and Histopathological Evaluation of Eyelid Lesions: Retrospective Analysis of Tertiary Medical Center Referrals
(Trakya Üniversitesi, 2021) İzzettinoğlu, Mustafa Ömer; Akay, Fatih Erkan; Garip, Rüveyde
Aims: To clinically and histopathologically examine eyelid lesions and evaluate the consistency of clinical examination by comparing the provisional diagnoses of patients with their postoperative histopathology results. Methods: In this study, the records of 408 patients who applied to Trakya University, Department of Ophthalmology with an eyelid mass and underwent surgery between January 2000 to November 2019 were retrospectively analyzed. Patients’ data comprised age, gender, location of the mass, lesion distribution according to age and gender, provisional clinical diagnosis of the patients, and histopathological reports. Results: Out of 408 patients, 220 (54%) were female, and 188 (46%) were male. The mean age of the patients was 46.9 ± 20.17 years (range; 5-90 years). In the histopathological examination of the lesions, 318 (77.9%) of them were benign, and 90 (22.1%) of them were malignant. The most common benign lesion was chalazion [112 (35.2%)], while the most common malignant lesion was basal cell carcinoma [71 (78.9%)]. The clinical pre-diagnosis and histopathological di- agnosis were found to be compatible in 81 (90%) patients with a malignant lesion. There was a statistically significant difference in age between malignant and benign lesions, where malignant lesions were found more in older patients. The histopathological examination ended up being malignant in 2.2% of the lesions with a benign provisional diagnosis. Conclusion: In conclusion, even though most common eyelid lesions in our study were found to be benign, some lesions diagnosed as benign in clinic were found to be malignant after histopathological examination. Hence all excisions should be evaluated histopathologically to achieve a better clinical outcome in all patients with an eyelid lesion.
Analysis of Clinical Relationship of Visual Acuity With Optical Coherence Tomography and Perimetry Parameters in Primary Open-Angle Glaucoma
(Trakya Üniversitesi, 2021) İzzettinoğlu, Mustafa Ömer; Gürlü, Vuslat
Aims: This study aims to analyze the clinical relationship of visual acuity with optical coherence tomography and perimetry in primary open-angle glaucoma. Methods: This retrospective cross-sectional study was conducted with patients who were diagnosed with primary open-angle glaucoma in the ophthalmology department of Trakya University School of Medicine between January 2010 and January 2021. Perimetric data of patients such as visual field index, mean defect, pattern standard deviation, short-term fluctuation, corrected pattern standard deviation; results of optical coherence tomography such as average retinal nerve fiber layer thickness, average C/D ratio, and thickness of retinal nerve fiber layer quadrants, and records of examinational findings were statistically tested to evaluate the statistical relationship. Numbers, percentages, mean and standard deviation were used as the descriptive statistics. Results: Initially 80 eyes of 49 patients diagnosed with primary open-angle glaucoma met the inclusion criteria. 22 patients were female and 27 patients were male. Thinner mean retinal nerve fiber layer, inferior and superior quadrants were observed in eyes with lower visual acuity. It was observed that eyes with lower visual acuity had a worse visual field index and mean defect. Conclusion: In tertiary clinics that receive various numbers of patient referrals, perimetry can be seen as more useful and accurate in primary open-angle glaucoma detection and monitoring. It provides us with better and more accurate results for glaucoma management in the later stages. It is recommended that both optical coherence tomography and perimetry be used for disease monitoring, as this allows doctors to better monitor disease progression. In addition, since optical coherence tomography is an objective test and is less likely to require a patient response, it should be kept in mind that advanced and severe glaucoma may occur when performing perimetry, especially in patients with poor cooperation.
Anizometropik ambliyopi olgularında iki göz arasında refraktif kusur farkına neden olan faktörler
(2006) Dervişoğlu, Sinan; Gürlü, Pelitli Vuslat; Erda, Nazan
Amaç: Anizometropik ambliyopi olgularının, ambliyop olan ve olmayan gözlerine ait refraktif, biyometrik ve topografik parametreleri karşılaştırılarak, anizometropi oluşumunda etkili olanlar tanımlanmaya çalışıldı. Hastalar ve Yöntemler: Altmış altı anizometropik ambliyopi olgunun (26 erkek, 40 kadın; ort. yaş 19.4±10.1; dağılım 7-47) 132 gözü çalışmaya alınarak, olgular prospektif olarak değerlendirildi. Olguların tümünün öncelikle otomatik refraktometre ile refraktif durumları objektif olarak saptanarak, Snellen eşeli ile düzeltilmemiş ve düzeltilmiş görme keskinlikleri ölçüldü. Kornea topografisi ile korneaya ait parametreler ve A Scan ultrasonografi ile ön-arka eksen uzunlu ğu elde edildi. Anizohipermetrop ve anizomiyop olmak üzere iki gruba ayrılan olguların ambliyop olan ve olmayan gözlerine ait parametreler karşılaştırıldı. Bulgular: Yapılan istatistiksel değerlendirmede anizohipermetrop ambliyopi olgularında; sferik değer, sferik eşdeğer, ön-arka eksen uzunluğu, total kornea astigmatizması, 3 mm alanda ve 5 mm alanda astigmatizma değerlerinin iki göz arasında istatistiksel olarak anlamlı şekilde farklı olduğu görüldü. Anizomiyoplarda ise, olguların gözleri arasında sferik eşdeğer, silindirik değer, 3 mm alanda ve 5 mm alanda astigmatizma değerleri istatistiksel olarak anlamlı derecede farklıydı. Sonuç: Bulgularımız, anizohipermetropik ambliyopi olgularında refraktif kusur farkından, ön-arka eksen uzunluğu ve/veya kornea astigmatizmasının; anizomiyop ambliyoplarda ise sadece kornea astigmatizmasının sorumlu olabileceğini düşündürmektedir.

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