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Öğe Salbutamol Ameliorates the Phenotype of the Skin Inflammatory Disease Psoriasis According to Skin Spheroid Models(Trakya Üniversitesi, 2021) Somuncu, Özge Sezin; Demiriz, Berke; Türkmen, İrem; Somuncu, Salih; Aksoy, BernaSedef hastalığı; genetik, bağışıklık sistemi ve çevrenin karşılıklı etkileşiminden kaynaklanan, çok faktörlü kronik inflamatuar bir hastalıktır. Epitel hücrelerinin hiperproliferasyonu ile karakterizedir ve hastaların yaşamında büyük olumsuz etkileri olan kırmızı, pullu psoriatik plaklar oluşturur. Kortikosteroidler veya D vitamini analogları iyileşmeye bir dereceye kadar yardımcı olabilse de hastalığın henüz tam bir tedavisi yoktur. Bu çalışmada, ?2-adrenerjik reseptör agonisti salbutamol'ün potansiyel etkinliğinin taranması için üç boyutlu (3D) stresle ilişkili psoriatik deri sferoidleri oluşturulması amaçlanmıştır. İnsan dermal fibroblast (HDF), İnsan epidermal keratinosit (HEK) ve İnsan monosit hücreleri (THP-1) ile 3D kültür modelleri oluşturulmuş ve buna göre stres kökenli psoriatik model protokolü uygulanmıştır. İlacın etkinliği, gen ve protein ekspresyon seviyelerindeki değişiklikler ve çeşitli metabolik deneylerle değerlendirilmiştir. Sedef hastalığının sferoid modellerini in vitro olarak büyütebilmek için optimize bir yöntem geliştirilmiştir. Salbutamol'ün sedef sferoidleri üzerindeki potansiyel terapatik etkileri test edilmiştir. Salbutamol ile tedavi edilen sferoidler, tedavinin etkinliğini kanıtlayan literatürle paralel sonuçlar göstermiştir. 3D sferoroid sistemimiz, in vitro olarak sedef hastalığının fizyolojik özelliklerini taklit etmede kısmen etkili bulunmuştur. Çalışmamız, stresle ilişkili bir psoriatik model oluşturduğu ve potansiyel bir tedavi seçeneği olarak bir ?2 agonistini deneyen ilk çalışma olduğu için bir başlangıç noktası olabilir. Salbutamol'ün etkileri ve uygunluğu göz önünde bulundurulduğunda etkinliği küçümsenmemeli ve gelecekte klinikte kullanım potansiyeli göz önünde bulundurulmalıdır.Öğe Attitude of Nursing Students Toward Scientific Research: A Cross-Sectional Study in Turkey(LIPPINCOTT WILLIAMS & WILKINS, 2018) Unver, Seher; Semerci, Remziye; Ozkan, Zeynep Kizilcik; Avcibasi, IlkerBackground: Nursing, a social applied science, is a dynamic profession. Professional nurses must be curious, investigative, and open to learning as well as practice critical and analytic thinking to sustain their professionalism. Purpose: The aim of this study was to determine the attitudes of nursing students toward scientific research. Methods: A descriptive and cross-sectional study design was used. This study was conducted at a nursing department of a university in Turkey. A sample of 375 nursing students participated. Data were collected using the "Personal Information Form'' and "Attitude Scale towards Scientific Studies.'' Standard descriptive statistical methods, correlation, Mann-Whitney U, Kruskal-Wallis, and post hoc Bonferroni were used in data analysis. Results: Nearly all (90.1%) of the participants were female, and 33.9% were sophomore (second-year) students. Junior (third-year) students held the most positive attitudes toward research, as compared with the participants in other academic years. Participants who had participated in scientific activities held more positive attitudes toward research than those who had not. Participants who had prior experience doing scientific research showed more positive attitudes toward research and researchers than those without this experience. Being older, having scientific research experience, following the continuous broadcasts related to nursing, and participating in scientific activities all significantly influenced attitude toward research (p<.05). Conclusions/Implications for Practice: Although nursing students who participated in this study exhibited generally positive attitudes toward scientific research, they had relatively little experience participating in scientific activities. Therefore, to foster a positive scientific research culture among undergraduate students, grants should be provided that encourage wider participation in scientific activities and offer opportunities for undergraduate students to do scientific research.Öğe Respectful care of human dignity: how is it perceived by patients and nurses?(BMJ PUBLISHING GROUP, 2018) Er, Rahime Aydin; Incedere, Aysel; Ozturk, SeldaObjective Dignified care protects the patient's rights and provides appropriate ethical care while improving the quality of nursing care. In this context, the opinions of nurses and patients who receive nursing care about dignified care are important. The aim of this study was to explore the opinions and experiences of Turkish patients and nurses about respectful care of human dignity. Methods This descriptive cross-sectional study was conducted in Turkey. Participants were inpatients at cardiology, neurology and neurosurgery clinics and nurses working in these clinics. The data for the study were collected from face-to-face interviews using questionnaires. The percentages of characteristics and preferences of the participants were calculated, and the results were analysed using statistical tests. Results A total of 150 patients and 78 nurses participated in the study. The patients stated that the protection of their rights was the most important factor for dignified nursing care. The nurses stated that being careful to not expose the patients' body and being respectful of the patients' privacy were important in dignified nursing care. The age of the patient, duration of the disease, number of hospitalisations and length of time the nurses had been working at the clinic caused significant changes in the factors considered important in dignified care. Conclusions Our findings provide a perspective on dignified care in the Turkish healthcare setting. There were some differences between patients and nurses in the factors considered important for dignified care. The discussion with patients and nurses related to care and practices that protect or detract from human dignity can provide insights to ethics.Öğe Relations among Pain, Pain Beliefs, and Psychological Well-Being in Patients with Chronic Pain(Elsevier Science Bv, 2018) Topcu, Sacide YildizeliBackground: Chronic pain influencing the quality of life and well-being of the patients are also affected by pain beliefs. Psychological well-being could make a person have positive pain beliefs and these could facilitate patients' coping skills. In the care of the patients with chronic pain, nursing interventions can improve patients' well-being. Aims: This study aimed to determine the relationship between pain, pain beliefs and psychological well-being in patients with chronic pain. Design: A cross-sectional and relational study. Subjects: This study was conducted with 86 patients with chronic joint pain. Methods: A convenience sample method was used in the research. Data were gathered using a Personel Information Form, The Pain Beliefs Questionnaire and Psychological Well-being Scale. Frequency, percentage, mean, standard deviation and correlation analysis were used for data assessment. Results: It was found that there was a statistically significant correlation between pain severity and organic pain beliefs, statistically significant negative correlation between frequency and severity of pain and psychological well-being, and statistically significant relationship between organic pain beliefs and the psychological wellbeing. Conclusions: Organic pain beliefs and pain intensity affect the psychological well-being of the patients with chronic pain. To increase the psychological well-being level of patients with chronic pain, patients' informations, attitudes and beliefs about pain and pain control should be changed positively. Also, nursing care focused on improving well-being should be provided by nurses. Further studies should be carried out on other factors affecting the well-being of patients as well as pain and pain beliefs on larger samples. (C) 2018 by the American Society for Pain Management Nursing
