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Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis
(Academic Press Inc Elsevier Science, 2022) Zaim, Omer; Doganlar, Oguzhan; Doganlar, Zeynep Banu; Ozcan, Hafize; Zreigh, Mohamed M.; Kurtdere, Kardelen
[Abstract Not Available]
Synthesis, Cancer-Selective Antiproliferative and Apoptotic Effects of Some (±)-Naringenin Cycloaminoethyl Derivatives
(Wiley-V C H Verlag Gmbh, 2018) Zaim, Omer; Doganlar, Oguzhan; Zreigh, Mohamed M.; Doganlar, Zeynep Banu; Ozcan, Hafize
Naringenin is a naturally occurring flavonoid and due to its broad spectrum of biological activities, including anticancer properties, has attracted scientific attention in recent years. To contribute to these studies, we synthesized some new (+/-)-naringenin cyclic aminoethyl derivatives, analyzed the cytotoxic and anti-proliferative properties of them via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, and mitochondrial apoptosis signaling response and gene expressions belong to caspase-3 depended apoptosis as biomarkers in both healthy and cancer cell lines. Our results suggest that some of our naringenin derivatives are potential anticancer agents with a selective death potential and targeting properties for mitochondrial apoptosis signaling against at least human cervix and breast cancer.