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    DOSE ESCALATION AND SWITCHING PATTERNS OF ANTI-TNF DRUGS IN RHEUMATOID ARTHRITIS: A RETROSPECTIVE CHART - REVIEW STUDY IN TURKEY
    (Bmj Publishing Group, 2015) Kalyoncu, U.; Aydin, S. Z.; Dalkilic, E.; Kasifoglu, T.; Kisacik, B.; Pamuk, O. N.; Yilmaz, S.
    [Abstract Not Available]
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    The Effects of Voluntary Physical Activity in Female Rats Fed with Fructose Rich Diet
    (Wiley, 2017) Tayfur, P.; Gokce, K.; Yilmaz, S.; Barutcu, O.; Ozgur, E. O.; Sut, N.; Vardar, S. A.
    [Abstract Not Available]
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    Sexual dysfunction of male, after pelvic fracture
    (Springer Heidelberg, 2017) Copuroglu, C.; Yilmaz, B.; Yilmaz, S.; Ozcan, M.; Ciftdemir, M.; Copuroglu, E.
    Purpose Pelvic fractures are usually the result of high-energy trauma, and sexual dysfunction after a pelvic fracture is an often complication. Though organic pathologies can be the reason for sexual disorders, psychological factors following a trauma may also be linked to sexual problems. We aimed to evaluate the frequency of sexual dysfunction after pelvic fractures, and help these patients with their usually undisclosed sexual problems, and offer them support. Materials and methods During a 4-year period, between June 2008 and May 2012, 40 male patients (out of 57) with a mean age of 42.6 years (range 18-65 years) were evaluated retrospectively. Patients having organic pathologies (vascular, neural, and urogenital system pathologies) were excluded from the study. Patients were requested to complete the Arizona Sexual Experience Scale (ASEX), which is a 5-item self-evaluation scale. According to the results of the questionnaire, patients needing supportive treatment were referred to the psychiatry department. Results Twenty-two patients (55 %) scored 10 points or less in the ASEX questionnaire (normal). Eighteen patients (45 %) had 11 points or more (can be problematic). Four of these 18 patients had a score of 19 points or more (needing psychiatric evaluation). Patients with a score of >= 19 points, for any one item with a score of 5 or 6 points, or any three or more items with a score of 4 points were considered to have a high probability of sexual dysfunction after psychiatric evaluation. Conclusion The frequency of sexual dysfunction in pelvic fractured patients was tested, and the need for investigating sexual disorders is stressed. This study attracts attention to sexual dysfunction after pelvic fractures and the necessity of referring these patients to the related clinics, for treatment. Level of evidence Retrospective case series.
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    Synthesis and investigation of binding interactions of 1,4-benzoxazine derivatives on topoisomerase IV in Acinetobacter baumannii
    (Taylor & Francis Ltd, 2017) Yilmaz, S.; Yalcin, I.; Okten, S.; Onurdag, F. K.; Aki-Yalcin, E.
    Acinetobacter baumannii has emerged as an important pathogen for nosocomial infections having high morbidity and mortality. This pathogen is notorious for antimicrobial resistance to many common antimicrobial agents including fluoroquinolones, which have both intrinsic and acquired resistance mechanisms. Fluoroquinolones targeting the bacterial topoisomerase II (DNA gyrase and Topo IV) show potent broad-spectrum antibacterial activity by the stabilization of the covalent enzyme-DNA complex. However, their efficacy is now being threatened by an increasing prevalence of resistance. Fluoroquinolones cause stepwise mutations in DNA gyrase and Topo IV, having alterations of their binding sites. Furthermore, the water-Mg+2 bridge, which provides enzyme-fluoroquinolone interactions, has a significant role in resistance. In this study, 13 compounds were synthesized as 1,4-benzoxazine derivatives which act as bacterial topoisomerase II inhibitors and their antibacterial activities were determined against multi-drug resistant Acinetobacter strains which have ciprofloxacin (CIP) resistant and GyrA mutation. Afterwards we performed docking studies with Topo IV (pdb:2XKK) of these compounds to comprehend their binding properties in Discovery Studio 3.5. The results of this study show significant conclusions to elucidate the resistance mechanism and lead to the design of new antibacterial agents as bacterial topoisomerase II inhibitors.