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Öğe Aromatase inhibitors and radiation-induced lung fibrosis(Amer Soc Clinical Oncology, 2008) Bese, N. S.; Altinok, A. Y.; Ozsahin, E. M.; Yildirim, S.; Sut, N.; Altug, T.; Ober, A.[Abstract Not Available]Öğe Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study(Churchill Livingstone, 2016) Altinok, A. Y.; Yildirim, S.; Altug, T.; Sut, N.; Ober, A.; Ozsahin, E. M.; Azria, D.Purpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats. Materials and methods: 60 female wistar-albino rats were divided into 6 groups: Control (group A), RT alone (group B), RT + TAM (group C), RT + anastrozole (ANA group D), RT + LET (group E), and RT + exemestane (EXE, group F). RT consisted of 30 Gy in 10 fractions to both lungs with an anterior field at 2 cm depth. Equivalent doses for 60 kg adult dose per day of TAM, ANA, LET, and EXE were calculated according to the mean weight of rats and orally administrated with a feeding tube. Percentage of lung with fibrosis was quantified with image analysis of histological sections of the lung. The mean score values were calculated for each group. the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test. Results: Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2.2 for groups A, B, C, D, E, and F, respectively (p = 0.000). TAM increased RT-induced lung fibrosis but without statistical significance. Groups treated with RT + AI showed significantly less lung fibrosis than groups treated with RT alone or RT + TAM (p = 0.000). RT + AI groups showed nearly similar RT-induced lung fibrosis than control group. Conclusions: In this study, we found that AI decreased RT-induced lung fibrosis to the control group level suggesting protective effect. (C) 2016 Elsevier Ltd. All rights reserved.Öğe Monitoring the peripheral blood lymphocyte subtypes in drug reaction with eosinophilia and systemic symptoms (DRESS)(Mosby-Elsevier, 2007) Yazicioglu, M.; Elmas, R.; Genchallacoglu, T.; Yildirim, S.; Turgut, B.[Abstract Not Available]Öğe A multicenter survey of childhood asthma in Turkey - II: Utilization of asthma drugs, control levels and their determinants(Wiley, 2009) Soyer, O. U.; Beyhun, N. E.; Demir, E.; Yildirim, S.; Boz, A. Bingoel; Altinel, N.; Cevit, O.Many surveys worldwide have consistently demonstrated a low level of asthma control and under-utilization of preventive asthma drugs. However, these studies have been frequently criticized for using population-based samples, which include many patients with no or irregular follow-ups. Our aim, in this study, was to define the extent of asthma drug utilization, control levels, and their determinants among children with asthma attending to pediatric asthma centers in Turkey. Asthmatic children (age range: 6-18 yr) with at least 1-yr follow-up seen at 12 asthma outpatient clinics during a 1-month period with scheduled or unscheduled visits were included and were surveyed with a questionnaire-guided interview. Files from the previous year were evaluated retrospectively to document control levels and their determinants. From 618 children allocated, most were mild asthmatics (85.6%). Almost 30% and 15% of children reported current use of emergency service and hospitalization, respectively; and 51.4% and 53.1% of children with persistent and intermittent disease, respectively, were on daily preventive therapy, including inhaled corticosteroids. Disease severity [odds ratio: 12.6 (95% confidence intervals: 5.3-29.8)], hospitalization within the last year [3.4 (1.4-8.2)], no use of inhaled steroids [2.9 (1.1- 7.3)], and female gender [2.3 (1.1-5.4)] were major predictors of poor asthma control as defined by their physicians. In this national pediatric asthma study, we found a low level of disease control and discrepancies between preventive drug usage and disease severity, which shows that the expectations of guidelines have not been met even in facilitated centers, thus indicating the need to revise the severity-based approach of asthma guidelines. Efforts to implement the control-based approach of new guidelines (Global Initiative for Asthma 2006) would be worthwhile.Öğe Prevalence of Allergic Rhinitis among Medical School Students in Edirne (Turkey) and the Impact of Symptoms on Quality of Life(Mosby-Elsevier, 2009) Yazicioglu, M.; Yildirim, S.; Celik, H.; Kaptan, B.; Teloren, B.; Aylanc, H.; Ture, M.[Abstract Not Available]
