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Öğe Anaphylaxis Management for Dentists: Knowledge and Preparedness(Bilimsel Tip Yayinevi, 2020) Celik, Velat; Ozdemir, Pinar Gokmirza; Beken, Burcin; Yucal, Melike; Yazicioglu, MehtapBackground: Anaphylaxis is not common in dentistry, but poor anaphylaxis management may lead to mortality. Objective: The aim of this study was to evaluate dentists' knowledge and preparedness to manage anaphylaxis. Materials and Methods: The study was designed as an online survey. It included questions about anaphylaxis management practices and the availability of equipment and medications in dental facilities. An online survey link was sent to members of the Turkish Dental Association (TDA). Results: A total of 952 TDA members responded to the survey. Fifty-seven point seven percent of dentists knew that adrenaline is the first choice drug to treat anaphylaxis. Fifty-two point four percent of dentists knew that intramuscular injection is the correct route of administration and 41.7% of dentists knew the correct dose to treat anaphylaxis. Only 15.3% of responding dentists answered all three questions correctly. Dentists who had previously been trained in the diagnosis and treatment of anaphylaxis performed better on questions about the first-choice drug, administration route, and dosage, when compared to untrained dentists (p<0.05). Of the responders, only 4.9% of dental facilities possessed complete medications and equipment capabilities to treat anaphylaxis. Conclusion: The majority of responding dentists did not seem to be aware of anaphylaxis management and did not have adequate equipment and medications for treatment of anaphylaxis in their dental facilities. There is an urgent need for undergraduate and postgraduate education programs to increase dentists' ability to manage anaphylaxis. The availability of emergency anaphylaxis medication and equipment in dental facilities should be ensured.Öğe Approach to drug allergies in the childhood(Aves, 2014) Yazicioglu, MehtapDrug reactions (DR) are adverse admissions or harmful effects of drugs. They constitute 6.5% of all hospital admission. DR develops with a rate of 15% in patients who are treated by hospitalization. The possibility of DR should be considered in the differential diagnosis when any medical problem occurs in a person who uses medication. Detailed history and physical examination are directive in differentiation if the reaction is a result of immune mechanisms. Although diagnostic tests are limited, they are beneficial according to the effective immune mechanism and presence of organ-specific or systemic findings. In children, the major difficulty in the diagnosis of DR is differentiation of maculopapular drug eruptions from viral exanthem which is observed very commonly in this age group. In treatment of allergic reactions, the first step is to immediately discontinue the responsible drug. Avoidance of using over-the-counter drugs and use of drugs orally if possible are important in terms of prevention of drug allergies. Cross-reactivity between drugs with similar structure should be considered when choosing an alternative drug. If an alternative drug or a drug which would not lead to cross-reaction can not be found, the drug is administered by desensitization. In this article, the apporach to drug allergies in children will be evaluated in accordance with current guidelines.Öğe Assessment of regular drug use and inhaler technique skills in asthmatic children(Elsevier Espana Slu, 2020) Can, Ceren; Akkelle, Emre; Ozdemir, Pinar Gokmirza; Yazicioglu, Mehtap; Sut, NecdetObjective: This study aimed to assess the regular use of long-term asthma-control medication and to determine inhaler techniques in asthmatic children. Methods: The study was conducted on asthmatic children aged 6-18 years. Information on rescue and controller medications was given and the proper inhalation technique was demonstrated. One month later, patients and parents were asked to answer a questionnaire on drug use and to demonstrate their inhaler techniques. Results: One hundred children and/or their parents were interviewed for the study. All of the patients identified long-term asthma-control medications white quick-relief asthma medications were identified by 93% of the patients. Of the patients, 34% described the dose of their quick-relief medication correctly. All steps in the inhalation technique were correctly carried out by 60.6% of patients using a metered-dose inhaler (MDI), 80% of patients using a Turbuhaler, and 58% of patients using a capsule-based dry-powder inhaler (DPI). Of the participants, 73% reported regular use of long-term asthma-control medications. While the mean age of the patients regularly using long-term asthma medications was 9.05 +/- 2.5 years, that of patients not compliant with the regular treatment was 10.29 +/- 3.26 years (p =0.04). The most common reason for irregular drug use was forgetting to take the drug. Conclusion: Adherence to long-term asthma-control medications tends to be better in younger patients. Since the most common cause of irregular drug use is forgetting to take the drug, repeated training is necessary to ensure asthma control and the successful treatment of asthmatic children. (C) 2019 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe The association between DRESS and the diminished numbers of peripheral B lymphocytes and natural killer cells(Wiley, 2012) Yazicioglu, Mehtap; Elmas, Reyhan; Turgut, Burhan; Genchallac, TugbaDrug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced, severe multiorgan system reaction whose exact pathogenesis remains unknown. This study aimed at evaluating specific changes in peripheral blood lymphocyte subtypes associated with DRESS during antibiotic treatment. We analyzed six patients with DRESS. A complete blood count and peripheral blood lymphocytes immunophenotyping were carried out at symptom onset and at follow-up visits. Acute-phase reactants and liver enzymes were measured in all patients. Other tests viral serology, serum immunoglobulin levels, and skin tests were performed when possible. B-cell counts were low in all patients at the onset of DRESS, and natural killer (NK) cells were low in all cases except one. During recovery, B-cell numbers were within a normal range in five patients. In one, there was even a 10-fold increase in B-cell counts, although the level was mildly low after 3 months. NK-cell numbers were within a normal range in three patients. The mean numbers of B cells and NK cells were significantly higher in the second samples compared to the values on admission. Serum IgA and IgM levels were low in one patient. The drug provocation test was positive with cefotaxime in one patient. Viral serology, performed on five patients, was negative. A decrease in B-cell and NK-cell counts was the most consistent finding associated with the onset of antibiotic-induced DRESS in our patients. This immunologic alteration might be a useful predictor of DRESS development.Öğe Chicken Meat Anaphylaxis in a Child with No Allergies to Eggs or Feathers(Iranian Scientific Society Medical Entomology, 2014) Can, Ceren; Yazicioglu, Mehtap; Ciplak, Gokce[Abstract Not Available]Öğe Do traditional fermented foods protect against infantile atopic dermatitis(Wiley, 2019) Celik, Velat; Beken, Burcin; Yazicioglu, Mehtap; Ozdemir, Pinar Gokmirza; Sut, NecdetBackground: Environmental and dietary factors during pregnancy may affect development of infantile atopic dermatitis (AD). This study analyzed whether maternal consumption of selected Turkish fermented foods (FF) and other factors during pregnancy affect the development of AD during the first 2 years of life. Methods: Eighty-four children with physician-diagnosed AD (aged between 2 and 24 months) and mothers, and 56 similarly aged, healthy children and mothers were studied. Physician-administered questionnaires retrospectively surveyed maternal consumption of FF during pregnancy. The intake frequency of 8 selected Turkish FF was classified as either (1) daily or (2) less than daily. Other possible demographic and environmental risk factors were also analyzed. Results: Daily maternal consumption of yogurt, fermented olive, and cheese in the control group was significantly higher than the AD group (P < 0.001, P = 0.017, and P = 0.011, respectively). Exposure to environmental tobacco smoking (ETS) was more common in the AD group than the control group (P = 0.025). In multivariate logistic regression analysis, maternal ETS exposure during pregnancy was associated with increased risk of infantile AD, and daily consumption of yogurt was associated with a reduced risk (odds ratio [OR]: 2.60, 95% confidence interval [CI]: 1.11-6.1, and OR: 0.22, CI: 0.09-0.54, respectively). The diversity of consumed FF during pregnancy was found to have a protective effect against infantile AD (OR: 0.27, CI: 0.14-0.53). Conclusions: Daily maternal intake of yogurt and diversity of consumed Turkish FF during pregnancy may reduce the risk of AD. Maternal tobacco smoke exposure is associated with increased risk of infantile AD.Öğe Generalized fixed drug eruption in a child due to trimethoprim/sulfamethoxazole(Wiley-Blackwell, 2014) Can, Ceren; Akkelle, Emre; Bay, Bade; Arican, Ozer; Yalcin, Omer; Yazicioglu, Mehtap[Abstract Not Available]Öğe Internet addiction and anxiety in asthmatic children after the first year of the COVID-19 pandemic(Galenos Publ House, 2023) Ozdemir, Pinar Gokmirza; Celik, Velat; Beken, Burcin; Ucar, Ozge Turkyilmaz; Kaplan, Sibel; Yazicioglu, MehtapObjective: Studies have revealed that people with asthma have a higher risk of anxiety during the COVID-19 pandemic. The relationship between internet addiction and anxiety has long been known, but to our knowledge, no studies have combined anxiety in asthmatic children and adolescents with internet use. This study investigated the relationship between anxiety levels and internet use in asthmatic children and adolescents during the late stage of the COVID-19 pandemic. Method: A multicenter survey was conducted in February -March 2021, enrolling 78 asthmatic patients and 44 healthy controls. Anxiety was assessed with the State -Trait Anxiety Inventory for Children (STAI-C) for children aged 9-12 and with the State -Trait Anxiety Inventory (STAI) for adolescents aged 13-18. Internet use was assessed with the Internet Addiction Scale for Adolescents (IASA). Results: Anxiety scores did not differ between patients and controls. The average time spent on the internet increased markedly (over three -fold) during the pandemic period compared to the pre -pandemic period (from 2.1 +/- 1.5 [0-6] hours per day to 6.9 +/- 3.5 [0-18] hours per day (p<0.001 in all participants). There was no difference in the IASA scores between the patients and controls. There was a correlation between the IASA and STAI state and trait (STAI [S] and STAI [T]) scores in the 13-18 year group (r=0.28, p=0.03, and r=0.34 p=0.01, respectively). Conclusion: Problematic internet use has more impact on anxiety in adolescents than asthma during the late stage of the COVID-19 pandemic. We suggest that internet addiction should be kept in mind when evaluating anxiety in asthmatic adolescents during their follow-up.Öğe Local allergic rhinitis: a pediatric perspective(Turkish J Pediatrics, 2020) Beken, Burcin; Eguiluz-Gracia, Ibon; Yazicioglu, Mehtap; Campo, PalomaLocal allergic rhinitis (LAR) is a differentiated rhinitis phenotype defined by perennial or seasonal rhinitis symptoms without systemic atopy. The diagnosis can be made by a positive response to the nasal allergen challenge (NAC) (the gold standard for diagnosis) in the absence of skin prick test and/or serum allergen-specific immunoglobulin E. Clinical and epidemiological studies have demonstrated that LAR affects individuals from different countries, races, and age ranges. Several studies have shown that the onset of nasal symptoms occurs during childhood in a significant proportion of LAR individuals. Evidence of LAR has been growing, especially in pediatric and Asian populations. A review of the literature reveals that most LAR studies of pediatric populations have appeared in the last three years. The prevalence of LAR in children ranges from 3.7% to 66.6%, and similar to what has been observed in adults, prevalence is higher in Western countries. Publications have shown that LAR in children can be either seasonal or perennial, and diagnosis of LAR confirmed by NAC have been reported with numerous allergens (house dust mites, pollens, molds, and dander). These findings illustrate that LAR is an important differential diagnosis in children with presumed non-allergic rhinitis, and a through review of the very recent literature can contribute to the clinical identification and diagnosis of LAR in children with no evidence of systemic atopy, as well as update readers' knowledge of the topic.Öğe Maternal anxiety and internet-based food elimination in suspected food allergy(Wiley, 2019) Beken, Burcin; Celik, Velat; Ozdemir, Pinar Gokmirza; Sut, Necdet; Gorker, Isik; Yazicioglu, MehtapBackground Food allergy is associated with stress, anxiety, and impairment in quality of life in both children and families. This study aimed to assess the anxiety of mothers in the case of suspected food allergy in their children and the influence of Internet usage on their levels of anxiety and food elimination. Methods Ninety-two patients aged 0-2 years presented at a pediatric allergy department following either a physicians' presumptive diagnosis or family's suspicion of food allergy (Group 1) and 99 healthy controls (Group 2) were evaluated. The clinical diagnosis of food allergy was confirmed or excluded by oral food challenge (OFC). The validated Turkish version of Spielberger State-Trait Anxiety Inventory (STAI) was applied to the mothers of both groups on admission and to Group 1 3 months after OFC. Results The state and trait anxiety (STAI-S and STAI-T) scores were significantly higher in Group 1 than Group 2 (P < 0.001, z = 5.410, and P = 0.021, z = 2.304, respectively). Seventy-nine mothers (85.9%) had been eliminating foods on admission. Thirty-seven (40.2%) mothers had eliminated foods on their own. The performance of food allergy-related Web searches was significantly higher among mothers who eliminated foods by themselves than those who did not (P = 0.004, chi(2) = 8.391, df = 1). The second STAI-S score was significantly lower among mothers whose children's food allergy diagnosis was excluded than confirmed (effect size = 1.06 (95% CI: 0.56-1.57), P = 0.001, z = 3.442). Conclusion It is important to make a correct food allergy diagnosis with a detailed allergy work-up, including OFC, to avoid anxiety and not cause unnecessary food elimination.Öğe Obsessive compulsive symptoms in mothers of children with atopic dermatitis(Termedia Publishing House Ltd, 2023) Celik, Velat; Beken, Burcin; Gorker, Isik; Ozdemir, Pinar Gokmirza; Sut, Necdet; Yazicioglu, MehtapIntroduction: Maternal stress, depression and anxiety are associated with atopic dermatitis (AD) in offspring. How- ever, the relationship between maternal obsessive compulsive symptoms (OCS) and AD in their children is unclear.Aim: To investigate whether maternal OCS are associated with AD in offspring.Material and methods: A total of 75 children with AD diagnosed by the paediatric allergist and 76 healthy children and their mothers were included in the study. A Turkish version of the Maudsley Obsessive Compulsive Inventory (MOCI-T) was used to assess OCS of mothers in both groups.Results: Total MOCI-T score and slowness, doubt, and rumination subscale scores were higher in the AD group than in the healthy group (p = 0.007, p = 0.001, p = 0.012 and p = 0.011, respectively) but washing/cleaning and checking subscale scores did not reach a statistically significant difference (p = 0.203 and p = 0.053, respectively). There was no correlation between SCORing Atopic Dermatitis (SCORAD) and MOCI-T/subscales scores.Conclusions: Our study provides evidence for associations between maternal OCS and infantile AD. The findings support recommendations for psychosocial support of mothers of children with AD.Öğe Oxcarbazepine-induced Stevens-Johnson syndrome: a pediatric case report(Oxford Univ Press, 2017) Beken, Burcin; Can, Ceren; Orencik, Aysegul; Can, Nuray; Yazicioglu, MehtapStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis are two rare but life-threatening diseases characterized by detachment of epidermis, bullous skin lesions and mucous membrane erosions. Anti-epileptic drugs are highly suspected to be the causative agents. Although carbamazepine (CBZ) is the most associated anti-epileptic drug, oxcarbazepine (OXC), which is a monohydrated derivative of CBZ, is proposed to be safer because of the different metabolism of the two drugs. Herein, we report a case of SJS induced by oxcarbazepine. A 6-year-old boy with benign rolandic epilepsy, admitted to our hospital with generalized maculopapular rash after starting oxcarbazepine. The diagnosis of SJS was made with cytotoxic skin lesions and mucous membrane involvement. After discontinuing of the drug and topical corticosteroid initiation, the lesions were improved. We report this case to attract attention to the serious side effect of this anti-epileptic drug.Öğe Parvovirus Infection in a Child Presenting with Erythema Multiforme and Vasculitis after a Yellow Jacket Bee Sting(Oxford Univ Press, 2021) Can, Ceren; Yazicioglu, Mehtap; Gokalp, Selman; Ozkayin, NeseParvovirus B19 has a wide spectrum of clinical manifestations. Erythema multiforme and vasculitis are rarely reported with parvovirus B19 infections. Reactions to insect stings can range from local swelling to life-threatening systemic reactions. There have been rare reports of unusual reactions, such as vasculitis, occurring in a temporal relationship with insect stings. We report an 8-year-old patient having Parvovirus B-19-related erythema multiforme and vasculitis after a yellow jacket bee sting.Öğe Perceptions of Parents and Physicians Concerning the Childhood Asthma Control Test(Taylor & Francis Ltd, 2012) Soyer, Ozge Uysal; Ozturk, Fadil; Keskin, Ozlem; Asilsoy, Suna; Altinel, Nazan; Karaman, Ozkan; Yazicioglu, MehtapBackground. The Childhood Asthma Control Test (C-ACT) has been proposed to be a simple, patient-based test that is able to reflect the multidimensional nature of asthma control. In this analysis, the aim was to evaluate the perceptions of physicians and caregivers concerning C-ACT and its predictive value for future asthma-related events. Method. In a multicenter prospective design, 368 children aged 4-11 years with asthma who were either well-or not well-controlled were included in the study. The study participants were evaluated during three visits made at 2-month intervals and the Turkish version of C-ACT was completed each month. Parents completed questionnaires concerning their perception of asthma (before and after the study) and the C-ACT (after the study). Physicians completed a survey about their perception of a control-based approach and the C-ACT. Results. The C-ACT scores increased from visit 1 to visit 3, with improvement seen in all domains of the test. At the end of the study period, the parents more strongly agreed that asthma could be controlled completely and that asthma attacks and nocturnal awakenings due to asthma were preventable (p < .05). Most of the parents reported that the C-ACT helped them to determine asthma treatment goals for their children and also that the C-ACT improved communication with their physicians. The physicians indicated that a control-centered approach was more convenient (95%) and simpler (94.5%) thana severity-centered approach and provided better disease control (93.4%). A higher C-ACT score was associated with a decreased risk of asthma attack and emergency department admittance in the 2 months following the administration of C-ACT. Conclusion. Our findings indicated that the C-ACT improved both parental outlook on asthma control and the communication between the physician and parents. There was a good correlation between the C-ACT score and the level of asthma control achieved, as described by the physician. Additionally the C-ACT score was predictive of future asthma-related events. These findings suggest that the C-ACT may have an important role in asthma management in the future.Öğe PHENYTOIN-INDUCED DRESS(Amer Coll Allergy Asthma Immunology, 2009) Yazicioglu, Mehtap; Mentes, Didem A.; Turgut, Burhan[Abstract Not Available]Öğe Prevalence of asthma among preschool children in Edirne, Turkey(Allergy Immunol Soc Thailand, 2007) Yolsal, Guner Emel; Yazicioglu, Mehtap; Ture, Mevlut; Kurt, ImranAllergic diseases generally begin early during childhood, but a late diagnosis is common. This study aimed to evaluate the prevalence of asthma and asthma-related symptoms among kindergarten children in Edirne, Turkey. 873 subjects based on a modified ISAAC questionnaire were included. The prevalence of 'wheezing ever' and 'wheezing during the previous year' was 23.3% and 8.6%, respectively. Prior physician diagnoses existed for 36 of 873 (4.1%) children. The prevalence of children undiagnosed with asthma, but reporting asthma-related symptoms was 3.1%, 51.9% of which had previous beta-agonist prescriptions. However, none of these children received inhaled anti-inflammatory medications. In conclusion, it was found that a large population of preschool children had undiagnosed respiratory symptoms suggestive of asthma. Conducting simple surveys of young children is particularly important, as identification of asthma early in the disease course will facilitate effective prevention and treatment.Öğe Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes(Mary Ann Liebert, Inc, 2020) Beken, Burcin; Serttas, Riza; Yazicioglu, Mehtap; Turkekul, Kader; Erdogan, SuatBackground: Atopic dermatitis (AD) is a common inflammatory skin disease with complex pathogenesis. Natural flavonoids exhibit strong anti-inflammatory and antioxidant properties in many human diseases. In this study, the potential bioactive effect of quercetin, a polyphenolic plant-derived flavonoid, on the AD model of human keratinocytes was evaluated. Methods: Immortalized human HaCaT keratinocytes were treated with interleukin (IL) -4, -13, and tumor necrosis factor-alpha to mimic AD features in vitro. Then effects of quercetin on inflammation, oxidative stress, and wound healing were assessed. Results: Pretreatment of the cells with 1.5 mu M of quercetin significantly reduced the expression of AD-induced IL-1 beta, IL-6, IL-8, and thymic stromal lymphopoietin, while it strongly enhanced the expression of superoxide dismutase-1 (SOD1), SOD2, catalase, glutathione peroxidase, and IL-10. Quercetin promoted wound healing by inducing epithelial-mesenchymal transition, which was supported by the upregulation of Twist and Snail mRNA expression. Unexpectedly, quercetin pretreatment of AD-induced cells upregulated the mRNA expression of occludin and E-cadherin, while downregulating matrix metalloproteinase 1 (MMP1), MMP2, and MMP9 expression. The pretreatment inhibited AD-induced phosphorylation of extracellular signal-regulated kinase 1/2/mitogen-activated protein kinase (ERK1/2 MAPK) and the expression of nuclear factor-kappa B (NF-kappa B), but it did not alter signal transducer and activator of transcription 6 (STAT6) phosphorylation. Conclusion: Quercetin may serve as a potential bioactive substance for atopic dermatitis-related symptoms through anti-inflammatory and antioxidant activities along with its acceleration of wound healing via ERK1/2 MAPK and NF-kappa B pathways.Öğe Relationship between arginase genes polymorphisms and preschool wheezing phenotypes(Wiley, 2021) Gokmirza Ozdemir, Pinar; Eker, Damla; Celik, Velat; Beken, Burcin; Gurkan, Hakan; Yazicioglu, Mehtap; Sut, NecdetBackground The association between arginase I (ARG1) and arginase II (ARG2) genes and asthma has been reported in previous studies, but associations between polymorphisms in ARG genes and preschool wheezing (PSW) phenotypes are still unknown. Objective To examine the association between genetic variation in ARG1 and ARG2 genes and PSW phenotypes. Methods We enrolled 83 patients and 86 healthy controls. The patient group included two subgroups: episodic wheezing (EW) (n = 42, median age 41 months) and multiple-trigger wheezing (MW) (n = 41, median age 39 months). We genotyped six single nucleotide polymorphisms (SNPs) in ARG1 and six SNPs in ARG2. Eighteen haplotypes for ARG1 and 31 haplotypes for ARG2 were constituted, and the distributions of SNPs and haplotypes in patients and controls were analyzed. Results The frequency of the homozygote cytosine-cytosine (CC) genotype of ARG1 rs2781667T>C SNP and the ARG1 haplotype 4 in the MW group was significantly higher than the EW group (p = .002; odd ratios [OR]: 5.25; confidence interval [CI]: 1.9-14.51 and p < .001; OR: 7.77; CI: 2.54-23.74, respectively). The frequency of the ARG1 haplotype 5 was significantly higher but the frequency of ARG1 haplotype 9 was significantly lower in the all patients than in the healty controls (p = .019; OR: 10.34; CI: 1.28-83.53 and p = .015; OR: 0.093; CI:0.01-0.74, respectively). The frequency of the ARG1 haplotype 2 was significantly higher in the EW group than in the MW group (p = .014; OR: 5.68; CI: 1.48-21.8). Conclusion Variations in ARG1 may potentially be related to phenotypes and risk of PSW.Öğe Residents and interns in the 3 university hospitals: their knowledge of and attitudes to drug allergy(Asia Pacific Assoc Allergy, Asthma & Clinical Immunology, 2020) Ozdemir, Pinar Gokmirza; Kizilca, Ozgur; Aylanc, Hakan; Celik, Velat; Beken, Burcin; Akbulut, Simge Dilan; Yazicioglu, MehtapBackground: Previous studies revealed there are many gaps in the awareness and knowledge regarding the diagnosis and management of drug allergy (DA) among various health-care professionals. Objective: To assess the knowledge, attitudes, and practices towards DA among residents and interns of 3 university hospitals in the region of Trakya (Thrace), Turkey. Methods: A cross-sectional survey was conducted at university hospitals of 3 cities in the Trakya region: 1. Trakya University Medical Faculty, Edirne (n = 405), 2. Namik Kemal University Medical Faculty, Tekirdag (n = 114), and 3. Canakkale 18 Mart University Medical Faculty, Canakkale (n = 111). A Turkish questionnaire was developed based on previous published studies. Results: The majority of participants (67%) had not received education on DA as a separate subject during their medical education. Less than a third (28.3%) of all respondents were satisfied with their knowledge concerning patients with clinical signs of DA. Of the 6 knowledge questions on DA, the average score for the study was 3.51 out of 6 (58.5%). Residents had a higher knowledge score (3.93 +/- 1.1) compared with interns (3.05 +/- 1.2) (p < 0.001). The lowest percentage of correct answers were in response to questions on laboratory confirmation of drug-related anaphylaxis (14.5%) and the possibility of penicillin toleration in patients with a history of penicillin allergy (11.8%). The majority of participants (92%) believe that medical doctors should be educated in DA. There were no significant correlations between taking DA histories and the frequency during daily practice of encountering patients. Conclusion: Our study revealed that DA knowledge and attitudes are not at satisfactory level among respondents, and we concluded the importance and necessity of reinforcement of DA education in pre- and postgraduate education of medical doctors.Öğe Retrospective Analysis of Skin and Drug Provocation Test Results of Children with Suspected Betalactam Allergy(Mosby-Elsevier, 2018) Yazicioglu, Mehtap; Akkelle, Emre[Abstract Not Available]
