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    The papulopustular lesion/arthritis cluster of Behcet's syndrome also clusters in families
    (Oxford Univ Press, 2012) Karaca, Mehmet; Hatemi, Gulen; Sut, Necdet; Yazici, Hasan
    Objective. We have previously reported distinct symptom clusters among our patients with Behcet's syndrome (BS). The presence of such clusters suggests that more than one pathogenetic mechanism might be operative in BS. Increases in the frequency of certain clusters in familial BS cases, if present, would further support this notion. To test this hypothesis, we compared the frequency of symptom clusters between familial (Group F) and non-familial (Group NF) cases of BS. Methods. We identified 380 BS patients who had reported a first-degree relative by reviewing 6031 patient charts. We were able to contact 186 (Group F). From the same initial pool, 500 patients were randomly selected. Of those, patients who did not report a family history of BS and who had attended our clinic during the previous 3 months made up Group NF (n = 221). Both groups were questioned about their symptoms within the previous 3 months. Data were analysed using factor analysis, cluster analysis and chi(2) tests. Results. The make-up of the symptom clusters were very similar for the factor and the cluster analyses. The frequency of papulopustular lesions and joint involvement cluster was significantly higher in Group F (39.2 vs 21.5%, P < 0.001). Furthermore, the same cluster was shared in 5/17 related pairs from Group F and in only 5/110 unrelated pairs from Group NF [29 vs 4.5%, P = 0.004; risk ratio (RR) = 6.47, 95% CI 2.15, 18.89]. Conclusion. The papulopustular lesions and arthritis cluster in BS appears to cluster in familial BS as well. This further supports the notion that the pathogenesis of BS may entail several distinct mechanisms resulting in separate phenotype clusters.
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    PPD REACTION IS NOT AUGMENTED IN BEHCET'S SYNDROME PATIENTS
    (Clinical & Exper Rheumatology, 2008) Hatemi, Gulen; Melikoglu, Melike; Sut, Needet; Yazici, Hasan
    [Abstract Not Available]
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    Vascular involvement in Behcet's syndrome: a retrospective analysis of associations and the time course
    (Oxford Univ Press, 2014) Tascilar, Koray; Melikoglu, Melike; Ugurlu, Serdal; Sut, Necdet; Caglar, Erkan; Yazici, Hasan
    Objective. Some features of Behcet's syndrome (BS) tend to go together. We aimed to explore the association and timing of various vascular events in both the venous and the arterial vascular tree. Methods. We conducted a chart survey on the type and time of vascular involvement of BS. The cross-relationships of involvement were assessed by phi correlation coefficients. Multiple correspondence analysis was used to identify patterns of vascular involvement. The risk of vascular recurrence was also estimated. Results. We identified 882 patients with vascular involvement among 5970 BS patients (14.7%). Deep vein thrombosis (DVT), almost always in the legs, was the most frequent single vascular event (592/882; 67.1%). The cumulative risk of a recurrent vascular event was 38.4% at 5 years. Patients with extrapulmonary artery involvement (EPAI) were significantly older than those with venous and pulmonary artery involvement (PAI). There were significant correlations between dural sinus thrombosis (DST) and PAI, Budd-Chiari syndrome (BCS) and inferior vena cava syndrome (IVCS) and between IVCS and superior vena cava syndrome (SVCS). Multiple correspondence analysis further indicated clustering of PAI, DST, BCS, IVCS and SVCS. However, EPAI and DVT clustered separately from forms of vascular disease, the separate clustering of the DVT being attributed to its propensity to occur solo. Conclusion. The most common type of vascular involvement in BS is solo DVT, almost always occurring in the legs. Various forms of venous disease in BS segregate together and PAI is included in this group. EPAI segregates separately.