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Öğe A giant ancient schwannoma mimicking an adnexal mass Case report(Lippincott Williams & Wilkins, 2016) Karakose, Oktay; Pulat, Huseyin; Oguz, Serhat; Zihni, Ismail; Ozcelik, Kazim Caglar; Yalta, Tulin Deniz; Eken, HuseyinIntroduction: Ancient schwannoma is a rare tumor of the peripheral nerve sheath. As degenerative properties are defined histologically, it can be wrongly interpreted as malignant. Case presentation: The case presented here is of a giant ancient schwannoma with a pelvic retroperitoneal location, which was mimicking an adnexal mass. Conclusion: In the rarely seen cases in the retroperitoneum, it may reach very large dimensions.Öğe Hemangiopericytoma at the Craniovertebral Junction: A Case Report(Kare Publ, 2019) Delen, Emre; Akinci, Ahmet Tolgay; Turkkan, Gorkem; Yalta, Tulin Deniz; Simsek, OsmanIntradural extra medullary hemangiopericytomas (HPCs) are extremely rare and a hemangiopericytoma located at the craniovertebral junction might present radiologic features similar to those of meningioma or schwannoma.To the best of our knowledge, this report is among a few reported cases of HPC at the craniovertebral junction. Although they are very rare, HPCs should kept in mind in the differential diagnosis of the intradural extramedullary lesion due to differences in treatment such as adjuvant radiotherapy.Öğe Importance of Ki-67 in human epidermal growth factor receptor 2 positive breast cancer(Imprimatur Publications, 2015) Erdogan, Bulent; Turkmen, Esma; Yalta, Tulin Deniz; Usta, Ufuk; Kodaz, Hilmi; Hacibekiroglu, Ilhan; Tanriverdi, OzgurPurpose: The aim of this study was to evaluate the importance of Ki-67 in Human Epidermal Growth Factor Receptor 2 (Her-2) positive breast cancer patients. Methods: We reviewed the records of patients diagnosed with Her-2-positive non-metastatic breast cancer between 2005 and 2011. Paraffin-embedded tissue samples were stained with MIB-1 mouse monoclonal antibody to find Ki-67 levels. Patients were grouped as low Ki-67 <20% and high Ki-67 >= 20%. Demographic and clinical features were compared. Results: One hundred and six patients were included in the study. Median follow up time was 41 months (range 15-100). Median age was 49.5 years (range 29-79). Twenty-nine patients (27.4%) were in the Ki-67 low group. Demographic features were similar in both groups. Lymphovascular invasion was more frequent in the Ki-67 high group, and hormone receptor (HR) positivity was more frequent in the Ki-67 low group (p=0.03, p=0.03, respectively). Recurrence rate was not significantly different in both groups (p=0.36). T stage (p=0.02), stage (p<0.01), lymphovascular invasion (p=0.02), ER status (p=0.02), and HR status (p<0.01) were related with recurrence. In multivariate analysis, stage and HR negativity were independent factors for recurrence (p<0.01, p=0.01, respectively). Recurrence sites were also similar in both groups. Survival rates at the third year for Ki-67 low group and Ki-67 high group were 94% and 92%, respectively. Conclusion: Her-2 positive patients with low Ki-67 and high Ki-67 had similar demographic and pathologic features except lymphovascular invasion and HR status. HR status was an important factor for disease course. Clinical course was determined by HR status rather than Ki-67.Öğe Prognostic Value of Angiogenesis and Survivin Expression in Patients with Glioblastoma(Turkish Neurosurgical Soc, 2016) Tastekin, Ebru; Caloglu, Vuslat Yurut; Oz Puyan, Fulya; Tokuc, Burcu; Caloglu, Murat; Yalta, Tulin Deniz; Can, NurayAIM: Glioblastoma (GBM) is the most common and the most aggressive primary brain tumor with poor prognosis. We aimed to evaluate the association between immunohistochemical expression of survivin and angiogenic parameters (microvessel density and vascular pattern) in patients who underwent surgery for GBM. MATERIAL and METHODS: The pathology reports and also clinical and follow-up data of patients with GBM were retrospectively evaluated. Control tissues were obtained from the archive for each antibody (Survivin, CD 34). Then, control staining of these antibodies was performed. Vessels were evaluated according to the standardized assessment of vascular pattern. RESULTS: Mean survival for classical vascular pattern was longer than bizarre vascular pattern (p<0.001). The survival time of patients decreased with increasing score of survivin staining. There was a significant correlation between survivin and survival time (p<0.001). There was no significant correlation between microvessel density and survival time (p>0.05). CONCLUSION: With these findings, it is considered that high expression of survivin, bizarre vascular pattern and development of secondary GBM correlates with the low survival rates, however microvessel density has no correlation with the survival rates. Since only malignant cells express survivin, it might be a target protein for the development of novel therapies.Öğe When the Mimic Coexists with the Mimicked(Aves, 2023) Ilgen, Ufuk; Ademoglu, Zeliha; Kalkan, Kubra Erol; Yalta, Tulin Deniz; Emmungil, Hakan[Abstract Not Available]