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Öğe Body mass index percentiles among adolescent girls living in Edirne, Turkey(Wiley, 2003) Karasalihoglu, S; Öner, N; Ekuklu, G; Vatansever, Ü; Pala, ÖBackground : Body mass index (BMI) is the simplest way to measure obesity; therefore, it is chosen by many authorities as a screening method for adolescent obesity. Body mass index is positively correlated with the complications of childhood and adolescent obesity, such as hypercholesterolemia, insulin resistance, hyper-tension and long-term development of cardiovascular diseases. The aim of the present study was to produce percentile curves for bodyweight, height and BMI in a representative sample of adolescent girls living in urban and rural areas of Edirne, Turkey, and to compare these percentile curves with curves from other countries. Methods : The present study was a cross-sectional study, including a representative sample of 1687 adolescent girls from rural and urban areas of Edirne, who were evaluated between May and July 2001. Bodyweight and height were measured using standard procedures. Body mass index (kg/m(2) ) was calculated as the ratio of bodyweight to body height squared. Smoothed percentiles for these variables were calculated using polynominal regression models. Crude weight, height and BMI percentile values, as well as smoothed percentile curves are presented. Results : Body mass index, weight and height reference curves for adolescent girls were produced. When we compared the BMI values of subjects in the present study with those of other countries, 85th and 95th percentiles of BMI in the present study were found to be generally lower than those for other ethnicities. Conclusion : Our findings show ethnic differences in BMI among adolescent girls. It will be usefull for each country to produce its own BMI percentiles.Öğe Dietary intakes among Turkish adolescent girls(Pergamon-Elsevier Science Ltd, 2005) Öner, N; Vatansever, Ü; Garipagaoglu, M; Karasalihoglu, SThe aim of this study was to obtain data about the nutritional intake of adolescent girls from Edirne, Turkey. In a sample of 940 healthy adolescent girls aged between 12 and 17 years, intake of macronutrients and micronutrients was assessed from 3-day self-reported food records. In general, macronutrient intake was found to be adequate whereas micronutrient intake was lower than the recommended dietary allowance (RDA). The percentage of energy distribution of the subjects derived from carbohydrates, proteins, and fats was 53.6%, 10.9%, and 35.5%, respectively. Compared with the RDA, reported intakes of thiamin, riboflavin, niacin, calcium, phosphorus, iron, zinc, and fiber were most likely to be inadequate; those of folic acid and potassium were adequate; and those of vitamins A and C were well above. Adolescent girls living in the rural area consumed lower amounts of energy, carbohydrate, protein, niacin, folic acid, vitamin C, and sodium and higher amounts of thiamin compared with those living in the urban area. Based on the findings of this study, a preventive nutritional concept for Turkish adolescent girls was proposed. (c) 2005 Elsevier Inc. All rights reserved.Öğe A newborn infant with left diaphragm agenesis, radial aplasia and preauricular appendices(Lippincott Williams & Wilkins, 2004) Öner, N; Basaran, ÜN; Yalçin, Ö; Vatansever, Ü; Acunas, BWe report the case of a baby girl born to consanguineous parents who died 36 hours after birth. She had multiple preauricular appendices, right radial aplasia, triphalangeal thumb and several other anomalies. Differential diagnosis included Fryns syndrome, Pallister-Killian syndrome, and hemifacial microsomia. However, since our patient had congenital diaphragmatic hernia, a rare finding in hemifacial microsomia we suggest that she had a variant form of hemifacial microsomia or an undescribed new syndrome.Öğe Nucleated red blood cell counts and erythropoietin levels in high-risk neonates(Blackwell Publishing Asia, 2002) Vatansever, Ü; Acuna, B; Demir, M; Karasalihoglu, S; Ekuklu, G; Ener, S; Pala, ÖBackground : The presence of increased numbers of nucleated red blood cells (NRBC) and increased levels of erythropoietin (EPO) in the circulation of neonates has been associated with states of relative hypoxia. The aim of this study is to assess the pattern of NRBC counts and EPO levels in a group of high-risk neonates under stress conditions and determine the short-term outcome for these babies by using these parameters. Methods : There were 69 high-risk neonates; 14 intrauterine growth retarded ( IUGR), 25 preterm infants, 18 term infants with asphyxia and 12 infants of diabetic mothers. Control groups included healthy, term infants delivered either vaginally (n=18) or with cesarean section (n=19). Three blood samples were obtained from each infant within 12 h (initial), 3 days and 7 days after birth to measure NRBC counts and EPO levels. Neonatal and short-term outcomes at 3 and 6 months of age were determined. Results : There was no significant difference among the groups with regard to the initial serum EPO concentrations. The initial NRBC counts were significantly lower in the control groups compared with the study groups (P=0.002). While there was no significant difference between patients with good and poor outcome in terms of EPO concentrations of initial samples, a significant difference existed in terms of NRBC counts (P=0.038). Conclusions : Both serum EPO level and NRBC count provide limited clinical benefit in the detection of pathological conditions of the neonatal period, but NRBC count determination seems to be especially helpful in predicting short-term neurodevelopmental outcome.Öğe The prevalence of folic acid deficiency among adolescent girls living in Edirne, Turkey(Elsevier Science Inc, 2006) Öner, N; Vatansever, Ü; Karasalihoglu, S; Ekuklu, G; Çeltik, C; Biner, BPurpose: A high incidence of iron-deficiency is a common observation among adolescent girls, whereas only limited data are available regarding the folic acid status of this group. This study was designed to determine the prevalence of biochemical folic acid deficiency in a group of Turkish adolescent girls. Methods: We Surveyed the serum folic acid, complete blood count, and dietary folic acid intake of Turkish adolescent girls after using three-clay self-reported food intakes in urban and rural areas of Edirne, Turkey. Results: A sample population was composed of 704 adolescent girls; their serum folic acid levels were found to be adequate for 37.6% (>= 6 ng/mL), marginal for 46% (3 to 5.9 ng/mL), and at deficient levels for 16.3% (< 3 ng/mL). Folic acid deficiencies were found in 20.1% (36 of 179) and 14.7% (61 of 416) of adolescent girls from rural and urban areas, respectively. Self-reported three-day folic acid intakes were correlated with the corresponding blood values for this nutrient. In the logistic regression analysis, three factors emerged as significant independent predictors of folic acid deficiency: low income (odds ratio [OR]: 2.4, 95% confidence interval [CI]: 1.3-4.2, p < .001), low vitamin C (OR: 1.9, 95% CI: 1.1-3.5, p < .05), and folic acid intake (OR: 4.8, 95% CI: 2.8-8.1, P < .001). Conclusion: Data from the present study may indicate that serum folic acid is low in a group of Turkish adolescent girls. These low values appear to be associated with low income, and low dietary intakes of folic acid and vitamin C. (c) 2006 Society for Adolescent Medicine. All rights reserved.Öğe Prevalence of underweight, overweight and obesity in Turkish adolescents(E M H Swiss Medical Publishers Ltd, 2004) Öner, N; Vatansever, Ü; Sari, A; Ekuklu, G; Güzel, A; Karasalihoglu, S; Boris, NWBackground: The aim of this study was to determine under-weight, overweight and obesity prevalence in a representative sample of adolescents living in urban and rural area of central Edirne, Turkey, and to compare the 95(th) percentile BMI curve to the curves of other countries. Material and methods: Data concerning the height and weight of 989 adolescents, aged between 12 and 17 years were collected. The prevalence of underweight was defined as the percentage of adolescents below the 5(th) percentiles of the American adolescents' age and gender specific BMI; prevalence of overweight and obesity were based on the cut off points of the International Obesity Task Force values (excess of the 85(th) and 95 h percentiles), respectively. Results: This study demonstrated that the prevalence of underweight, over-weight and obesity among adolescent girls was 11.1%, 10.6% and 2.1%, respectively, while it was 14.4%, 11.3% and 1.6% for adolescent boys. In the urban area the prevalence of underweight, overweight and obesity among adolescent girls was 10.0%, 10.3% and 2.1%, while it was 14.4%, 11.6% and 1.6% for boys, respectively. In the rural area; the prevalence of under-weight, overweight and obesity among adolescent girls was 15.7%, 12.4% and 2.2%, while it was 14.5%, 9.6% and 1.2% for boys, respectively. Discussion: Analyses of data collected during these studies support that adolescents living in the city of Edirne carry relatively lower further risk of over-weight and obesity than adolescents in other countries do.Öğe The protective role of melatonin in experimental hypoxic brain damage(Blackwell Publishing, 2005) Tütüncüler, F; Eskiocak, S; Basaran, ÜN; Ekuklu, G; Ayvaz, S; Vatansever, ÜBackground: It is known that oxygen-derived free radicals play an important role in the pathogenesis of brain injury. Melatonin is a powerful scavenger of the oxygen free radicals. In this study, the protective effect of melatonin against the damage inflicted by reactive oxygen species during brain hypoxia was investigated in newborn rats using biochemical parameters. Methods: For biochemical analyses, the levels of lipid peroxidation product (malondialdehyde ([MDA]), levels of reduced glutathione (GSH) and the activities of superoxide dismutase (SOD) and catalase (CAT) were estimated. Results: After the third day of brain hypoxia, the brain levels of MDA increased. Pretreatment of animals with melatonin abolished the rise in MDA induced by hypoxia. GSH concentration did not increase by pretreatment with melatonin. Additonally, the activities of two antioxidative enzymes (SOD and CAT) decreased after the experimental period with melatonin only preventing the change of CAT. The activity of SOD was not influenced by melatonin administration as expected. Conclusion: In this experimental study, exogenously administered melatonin effectively protected against brain injury by oxidative stress. This protective effect of melatonin may be due to its direct scavenger activity and activation of CAT. Thus, melatonin may potentially be useful in the treatment of neurodegenerative conditions that may involve free radical production, such as perinatal hypoxia.Öğe Systemic lupus erythematosus presenting with generalized lymphadenopathy -: A case report(Turkish J Pediatrics, 2001) Biner, B; Acunas, B; Karasalihoglu, S; Vatansever, ÜSystemic lupus erythematosus (SLE) is an immune complex disease with many different clinical presentations. Here we report a 13-year-old female patient presenting with generalized lymphadenopathy, who meanwhile developed butterflly rash and pericarditis. The diagnosis of SLE was based on the clinical features, positive antinuclear antibody, and positive antibodies to dsDNA. The patient had an active disease and developed renal involvement, despite steroid therapy. The patient's clinical presentation, course and response to therapy are detailed, and the literature on lupus lymphadenitis is reviewed.Öğe Thrombocytopenia(Blackwell Science Asia, 2000) Acunas, B; Çeltik, C; Vatansever, Ü; Karasalihoglu, SBackground: The conventional therapeutic approach in polycythemic newborn infants is to apply partial exchange transfusion (PET) when hematocrit value exceeds 70% or when the infant develops symptoms with the exception of plethora. Methods: In order to investigate the possibility of using platelet count as a simple criterion implying the PET requirement, we retrospectively reviewed polycythemic newborn infants with respect to the relationship between thrombocytopenia and severity of symptoms, and the association of platelet count and the PET performance. Thrombocytopenia has been defined as a platelet count < 150 000/mu L. Results: We studied 18 polycythemic infants with thrombocytopenia (group 1, 35%) and 34 without it (group 2, 65%). Perinatal asphyxia, gestational toxemia and intrauterine growth retardation, which are the three common causative factors leading to polycythemia, were not significantly different in the two groups. No correlation existed between platelet counts and hematocrit values within each group, but there was a very significant difference between the two groups in terms of severity of clinical findings (P < 0001); no difference in terms of moderate findings and moderately significant difference with respect to mild symptoms and asymptomatic situation (P < 0.05). Partial exchange transfusion was performed in all patients in group 1, while only 12 infants in group 2 (32%) received transfusion and the difference was statistically significant (P < 0.05). A significant rise in platelet counts has been achieved only in group 1, while hematocrit values decreased significantly in both groups following PET. Conclusions: This study emphasizes the relationship between thrombocytopenia and the severity of clinical findings and PET performance rate in polycythaemic newborn infants, implying that thrombocytopenia is a possible marker of hyperviscosity, the results of which warrant further investigation.Öğe VACTERL-H with triphalangeal thumb and hypothyroidism in a female patient(Lippincott Williams & Wilkins, 2004) Vatansever, Ü; Basaran, ÜN; Güzel, A; Acunas, B; Balci, SThe association of vertebral, cardiac, renal, limb anomalies, anal atresia, tracheo-esophageal fistula (VACTERL) with hydrocephalus (VACTERL-H) has recently been described. Both X linked and autosomal recessive forms have been described which are mostly indistinguishable clinically. Here we report a female newborn infant with hydrocephalus detected antenatally, oesophageal atresia with tracheo-oesophageal fistula, anal atresia, renal and vertebral anomalies, and triphalangeal thumb as well as primary hypothyroidism.
