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Öğe Different responses of apoptotic, inflammatory and heat shock protein gene expression to a single bout of high-intensity interval exercise between physically active and inactive men(Canadian Science Publishing, 2021) Vardar, S. A.; Doganlar, Z. B.; Kaya, O.; Tayfur, P.; Sut, N.; Doganlar, O.High mechanical load of muscles may induce muscular apoptosis on the one hand and adaptation to exercise on the other. This study aimed to explore whether changes of circulatory levels of inflammation, apoptosis and heat shock proteins (HSPs) messenger RNA (mRNA) following single bout of high-intensity interval exercise (HIIE) differs between physically active (PA) and inactive (PI) men. Nine PA and 9 PI (peak oxygen consumption: 2.6 +/- 0.4 vs. 2.0 +/- 0.2 L.min(-1)) healthy men (age: 28.7 +/- 6.3 vs. 30.2 +/- 4.5 years and body mass index: 2.6 +/- 2.1 vs. 23.3 +/- 2.8 kg.m(-2)) performed HIIE, comprising 4 repeats of a Wingate test (load: 0.050 kg.kg(-1) body weight). Blood samples were collected before exercise, 5 min after HIIE, and 24 h after HIIE for measuring mRNA of inflammation markers interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), apoptosis markers including Bcl-2, Bax, and HSP27, HSP60, HSP70, HSP90 using quantitative real-time PCR analysis. Post-HIIE IL-6, TNF alpha and HSP60 were higher in the PI than the PA group 5 min after exercise (p = 0.003, effect size (ES) = 1.59; p = 0.007, ES = 1.59 and p = 0.027, ES = 1.10 respectively). HSP70 acutely increased only in the PA group (p = 0.024, ES = 1.20). The increase in Bcl-2 (p = 0.047, ES = 1.08) and Bax (p = 0.024, ES = 1.20) levels were higher in the PI group 5 min after HIIE. The present study indicated that the response of inflammatory, apoptosis and HSP gene expressions to HIIE in blood of healthy male volunteers strongly depends on their level of regular physical activity. Novelty: Blood IL-6 and HSP60 mRNA levels following high intensity exercise may indicate metabolic stress. Increased blood HSP70 mRNA in physically active men may show an alternative apoptosis suppression pathway.Öğe Effect of high protein diet and exercise on cardiac Aquaporin 7 expression(Wiley-Blackwell, 2014) Palabiyik, O.; Karaca, A.; Vardar, S. A.; Tastekin, E.; Yamasan, B. E.; Tokuc, B.; Sipahi, T.[Abstract Not Available]Öğe The Effects of Voluntary Physical Activity in Female Rats Fed with Fructose Rich Diet(Wiley, 2017) Tayfur, P.; Gokce, K.; Yilmaz, S.; Barutcu, O.; Ozgur, E. O.; Sut, N.; Vardar, S. A.[Abstract Not Available]Öğe Hemodynamic effects of Isatin on isolated perfused heart(Wiley-Blackwell, 2014) Vardar, S. A.; Guksu, Z.; Vardar, S. A.; Palabiyik, O.; Karaca, A.; Tastekin, E.; Sut, N.[Abstract Not Available]Öğe Pulmonary microvascular permeability and gas exchange in patients with syndrome X(Lithographia, 2012) Durmus-Altun, G.; Vardar, S. A.; Salihoglu, Y. S.; Aktoz, M.; Dirlik, B.; Altun, A.Aim: This clinical study was planned to assess pulmonary microvascular permeability in patients with Syndrome X (SX) by using a functional imaging tool, technetium-99m-diethyltriaminepentaaceticacid (Tc-99m-DTPA) lung clearance scintigraphy, and the pulmonary functions test, which includes diffusion capacity of the lung for carbon monoxide (DLCO). Methods: The study population consisted of 22 non-smoker subjects divided into two groups. First group comprised 12 patients (4 male, 8 female, mean age: 48 +/- 4 years, range 36 to 65) with SX. Ten healthy subject (4 men, 6 female, mean age: 45 +/- 3 years, range 34 to 58) were served as control group. Volumetric pulmonary functions, including DLCO were also performed before lung scintigraphy. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled Tc-99m-DTPA using a gamma camera. Results: Spirometric data was comparable in both groups. Although volumetric pulmonary measurements were similar, DLCO values of SX patients were lower than those in control (20.9 +/- 1.7 ml/min/mmHg vs. 27.8 +/- 1.3 ml/min/mmHg, p=0.002). The mean clearance rate of Tc-99m-DTPA in control subjects was 106 +/- 6 min, and this value was lower than patients with SX (179 +/- 19 min; p=0.0001). Conclusion: We conclude that lung is a target organ for SX. The pulmonary gas exchange and microvascular permeability, which is measured by 99mTc-DTPA scintigraphy, are restricted without change of volumetric pulmonary functions in patients with SX. Hippokratia 2012; 16 (2): 113-117