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Öğe Brain metastases occurrence among metastatic breast cancer: A single oncology center experience.(Amer Soc Clinical Oncology, 2005) Uygun, K; Karagol, H; Tokatli, F; Caloglu, M; Donmez, S; Tas, F[Abstract Not Available]Öğe Clinical parameters and treatment results in recurrent granulosa cell tumor of the ovary(Academic Press Inc Elsevier Science, 2003) Uygun, K; Aydiner, A; Saip, P; Kocak, Z; Basaran, M; Dincer, M; Topuz, EObjectives. The objectives of this study were to evaluate the patients' characteristics and treatment results for 11 recurrent granulosa cell tumors (GCT) of the ovary. Methods. Tumor registries were screened retrospectively for all patients treated between 1979 and 1999 for ovarian tumors at the University of Istanbul. All information about these patients was obtained from operation, pathology, and follow-up reports. Then the clinical data were extracted. The patients were classified in stages according to FIGO criteria. There were 952 ovarian carcinomas, of which 45 were GCT. Eleven of 45 patients (24%) developed recurrent disease on follow-up. Results. All patients but one had advanced (III-IV) disease at diagnosis. The median progression-free interval (PFI) was 16 months (range, 5-39 months) with a marked difference in PFI between patients receiving (24 months) and not receiving (8 months) initial chemotherapy. Among patients received chemotherapy (six patients), two complete and two partial responses were observed, for an overall response rate of 67%. The median survival for all patients was 26 (4-73) months with a longer survival (38 versus 8 months) for patients retreated with a platinum-containing regimen. Conclusions. Despite the fact that small number of treated cases does not allow an adequate evaluation, retreatment with cis-platinum-containing regimens may be the treatment of choice for patients with recurrent disease. (C) 2003 Elsevier Science (USA). All rights reserved.Öğe Fatal hepatic veno-occlusive disease in an adult patient with Wilms' tumour(Elsevier Science London, 2003) Uygun, K; Kocak, Z; Cicin, I; Caloglu, M[Abstract Not Available]Öğe Granulosa cell tumor of the ovary - Retrospective analysis of 45 cases(Lippincott Williams & Wilkins, 2003) Uygun, K; Aydiner, A; Saip, P; Basaran, M; Tas, F; Kocak, Z; Dincer, MAdult granulosa cell tumors of the ovary are rare neoplasms, accounting for less than 5% of all ovarian malignancies. In addition to the tumor stage, residual disease, patient age, tumor size, extent of surgery, and also some histologic factors have been reported to be of prognostic importance. Tumor registries were screened for all patients treated between 1979 and 1998 for ovarian tumors at the University of Istanbul. There were 952 ovarian carcinomas, of which 47 were granulosa cell tumors. All charts were reviewed, and the clinical data were extracted. Prognostic factors and treatment results were evaluated retrospectively. The median follow-up was 84 (range: 6-141 months) months. According to univariate analysis, there were only two significant factors for overall survival (OS): stage and presence of residual disease. The OS of the 23 patients with early stage (mean, 122 months; median, unreached) was significantly (p = 0.0001) better than the OS of the 22 patients with advanced stage (mean, 34 months; median, 21 months). A significant difference (p = 0.0004) in OS was also observed between patients with residual (mean, 42 months; median, 21 months) and nonresidual (mean, 108 months; median, unreached) disease. In a multivariate analysis, only stage remained statistically significant (p = 0.0001). The overall 5-year survival rate was 55% and median survival after recurrence was 21 months. Despite the small number of patients, the study showed that stage and macroscopic residual disease are significant prognostic factors. The benefit of chemotherapy and radiotherapy remains controversial.Öğe Isolated bilateral sixth nerve palsy secondary to metastatic carcinoma: a case report with a review of the literature(Elsevier Science Bv, 2003) Kocak, Z; Celik, Y; Uzal, MC; Uygun, K; Kaya, M; Albayram, SIsolated sixth nerve palsies usually occur in the vasculopathic age group and are often associated with diabetes mellitus, hypertension, and atherosclerosis but also occur in the presence of skull base tumors. However, isolated bilateral sixth nerve palsies are an extremely rare complication of skull base lesions due to metastatic neoplasms. A case of a 46-year-old man with metastatic small-cell carcinoma of the lung that developed acute bilateral abducens nerve palsies is presented. Although this appears to be an isolated case, metastasis to the skull base must be included in the differential diagnosis of isolated bilateral sixth nerve palsies. (C) 2003 Elsevier B.V. All rights reserved.Öğe Isolated bone metastasis in testicular germ cell tumors: A case report and review of the literature(Karger, 2006) Uygun, K; Karagol, H; Kocak, Z; Cicin, I; Yalcin, O; Caloglu, M; Simsek, OBackground: In testicular germ cell tumors ( GCT), bone metastases are usually seen late in the disease progress and are almost always associated with involvement of other sites. However, isolated bone metastasis is an extremely rare finding in these patients. Case Report: A 43-year-old man was admitted to the neurosurgery department of our hospital suffering from dysarthria, ataxia, headaches and a progressive swelling above the parietooccipital region of the skull. Radiological, biochemical and pathologic tests showed that the lesion of the skull was an isolated skull metastasis as an initial manifestation of nonseminomatous GCT of the testis. Discussion: When a young patient presents with bone pain or painless swelling, even if it is an unusual site and isolated, testicular GCT should be considered as a differential diagnosis, as these lesions could be the first evidence of metastatic GCT.Öğe Rising lung cancer deaths among younger individuals: Lung carcinoma in a patient at the age of 26(Karger, 2004) Kocak, Z; Uzal, MC; Uygun, K[Abstract Not Available]Öğe Unusual metastatic site in a case of carcinoma of the hypopharynx: Nasal tip(B C Decker Inc, 2005) Kocak, Z; Uygun, K; Uzal, MC; Cicin, I; Yalcin, O[Abstract Not Available]
