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Öğe Helicobacter pylori and mean platelet volume: a relation way before immune thrombocytopenia?(Verduci Publisher, 2015) Umit, H.; Umit, E. G.OBJECTIVE: Helicobacter pylori is associated with chronic immune thrombocytopenia. Eradication of H. pylori has been related with a platelet response and this treatment has been included within management strategies for a certain group of patients. However, in patients with normal platelet counts, the effects of H. pylori infection on platelet count and mean platelet volume as an important platelet index have not been investigated. In this study, we aimed to assess the relation between platelet indices and H. pylori infection in patients with dyspepsia who have otherwise normal platelet counts. PATIENTS AND METHODS: In a retrospective manner, 4823 patients with dyspeptic complaints who have underwent an upper gastrointestinal endoscopy and a rapid urease test were included. Data of whole blood counts before the procedure were recorded from their files. Patients with normal endoscopic findings or simple gastritis were included. Patients with malignancy, GI bleeding, portal hypertension, liver or kidney disease and taking nonsteroidal anti-inflammatory drugs, proton pump inhibitors, cytotoxic medications were excluded. RESULTS: Mean platelet count in H. pylori positive and negative patients were 246381+/- 92225/mm(3) and 258135 +/- 89912/mm(3), respectively (p< 0.001). Mean MPV was higher in H. pylori positive group (8.9+/- 1.3 vs. 8.23 +/- 0.94, p< 0.001). This difference was observed in both genders. MPV was observed to be higher than 10 fL in 20.5% of HP positive patients while in only 2.8% of H. pylori negative patients (p< 0.0001). CONCLUSIONS: In patients with H. pylori infection and normal platelet counts, it may be speculated that an ongoing and compensated platelet destruction-production process may be responsible for the increase in MPV. Likewise, in conditions exclusive for the host or the H. pylori strain, platelet destruction may be enhanced leading to immune thrombocytopenia. As our study is the first study to investigate the effect of H. pylori in patients with normal platelet counts, our findings may give way to further prospective researches.Öğe An increased frequency of gallbladder stones in rheumatoid arthritis patients.: Factors related to gallbladder stone formation(Clinical & Exper Rheumatology, 2006) Pamuk, O. N.; Umit, H.; Unlu, E.; Koker, I. H.; Cakir, N.Objective. In this study, we determined the frequency of gallbladder stone (GBS) in rheumatoid arthritis (RA) patients and evaluated factors which could affect the formation of GBS such as lipids and the GB motilities of the patients. Methods. One hundred and thirteen RA patients (92F, 21M, mean disease duration: 8.9 years) and 117 healthy controls (94F, 23M) were included. In all RA patients, the clinical findings were recorded down; biochemical parameters and body mass index (BMI) were determined; and, abdominal ultrasonography was performed. In addition, 16 RA patients and 20 controls who were age-matched were randomly chosen for GB emptying monitored by ultrasound at 30-minute intervals for 2 hours after a mixed meal. Fasting volume (FV), residual volume (RV) and ejection fraction (EF) for all GBs were assessed. Results. There was a tendency towards a higher frequency of GBS including cholecystectomy (11 GBS, 11 cholecystectomy, 19.5%) in RA patients when compared to controls (8 GBS, 5 cholecystectomy, 11.1%) (p = 0.08). The frequency of GBS plus cholecyctectomy in female RA patients (22.8%) was significantly higher than the control group (11.7%, p = 0.044). Logistic regression analysis showed that only older age was significantly associated with the presence of GBS in RA (OR:1.05, p = 0.048). There was no difference between the 2 groups in FV (p > 0.05). RV PRV and EF were significantly higher in RA patients than in the control group (p < 0.05). Conclusions. We diagnosed a higher frequency of GBS in female RA patients when compared to controls. Impaired GB motility in RA patients might contribute to an increased incidence of GBS development.Öğe The rate of drug usage and side-effects in inflammatory bowel disease(Oxford Univ Press, 2014) Can, G.; Tezel, A.; Unsal, G.; Ustundag, A.; Umit, H.; Soylu, A. R.[Abstract Not Available]Öğe Time-to-diagnosis in inflammatory bowel disease(Oxford Univ Press, 2014) Can, G.; Tezel, A.; Unsal, G.; Ustundag, A.; Umit, H.; Soylu, A. R.[Abstract Not Available]
