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Öğe Assessment of patients with von Willebrand disease with ISTH-BAT and PBQ scores(Wiley, 2019) Belen, F. B.; Umit, E. G.; Zengin, Y.; Evim, M. S.; Unal, E.; Ozbas, H. M.; Acipayam, C.[Abstract Not Available]Öğe Autoimmune rheumatic disease associated symptoms in fibromyalgia patients and their influence on anxiety, depression and somatisation: a comparative study(Clinical & Exper Rheumatology, 2012) Donmez, S.; Pamuk, O. N.; Umit, E. G.; Top, M. S.Objective. In this study we evaluated the frequency of autoimmune rheunzatic disease associated major symptoms in fibromyalgia (FM) patients, and the association between their presence and anxiety, depression and somatisation. Methods. Two hundred and thirty-two FM, 78 systemic lupus erythematosus (SLE) patients and 70 healthy controls were included. All subjects were questioned face-to-face for the presence of autoimmune rheumatic disease-associated symptoms and antinuclear antibody (ANA) was determined. All FM patients were questioned for the severity of pain and symptoms of FM by using a visual analogue scale. In addition, all subjects were interrogated for anxiety, depression, somatic symptoms and neuropathic pain by using different validated questionnaires. Results. FM patients had significantly higher frequency of photosensitivity (27.6% vs. 11.4%) and Raynaud phenomenon (22% vs. 10%) when compared to controls (p-values, 0.005 and 0.026). FM patients had significantly lower frequencies of photosensitivity, oral ulcers, xerostomia, and xerophthalmia than SLE patients (all p-values <0.001). ANA positivity was 11.8% in FM patients and 7.1% in healthy controls. ANA-positive and negative FM patients had similar frequencies of autoimmune rheumatic disease symptoms. FM patients with photosensitivity had higher anxiety (p=0.002), somatic symptoms (p=0.015) and neuropathic pain (p=0.03) scores than others. FM patients with Raynaud had higher anxiety (p=0.004), depression (p=0.001), somatic symptom (p<0.001) and neuropathic pain scores than others. Conclusion. The presence of which findings in FM seems to be associated with anxiety, depression, and somatisation rather than ANA positivity and disease severity.Öğe CD11c expression in chronic lymphocytic leukemia revisited, related with complications and survival(Wiley, 2017) Umit, E. G.; Baysal, M.; Durmus, Y.; Demir, A. M.Introduction: Chronic lymphocytic leukemia (CLL) is a disorder of mature but dysfunctional monoclonal B cells. Microenvironment, antigenic stimulation and genetical mutations are demonstrated in etiopathogenesis. We aimed to evaluate the expression of CD11c in patients with CLL and its possible clinical significance. Methods: Data of 259 patients with CLL between 2010 and 2016 in Trakya University Faculty of Medicine, including age at diagnosis, sex, whole blood count, stage, percentage of CLL cells in bone marrow, line of treatments, development of Richter's transformation and secondary tumors, autoimmune complications, IgG level, prognostic cytogenetic analysis, and length of survival were recorded from files. Results: 151 patients were male (58.3%) and 108 were male (41.7%). Mean age was 70 (21-92)years. CD11c was observed to be positive (>%20) in 103 patients (39.8%). Development of Richter's transformation, secondary tumors and ITP was significantly frequent in patients with CD11c positivity (P values .000, .003, .000 respectively). Also, IgG levels were significantly lower in this group (P=.000). Hemoglobin level, RAI stage and bone marrow CLL infiltration percentage were statistically related with CD11c (P values .036, .037, .000 respectively). Finally, CD11c was statistically related (in positive group 70 months, negative group 79 months, P=.001). Conclusion: CD11c, expressed not only in Hairy cell leukemia but also in dendritic cells, macrophages and monocytes is a differentiation marker for inflammation. Prolonged inflammation in the microenvironment of CLL cells may cause a susceptibility to autoimmune disorders and secondary tumors in CLL, in this way, an increase in mortality.Öğe DEPRESSION AS THE PRESENTING SYMPTOM OF CENTRAL NERVOUS SYSTEM LYMPHOMAS IN NORTHWESTERN TURKEY(Ferrata Storti Foundation, 2017) Umit, E. G.; Esen, D. B.; Baysal, M.; Demir, A. M.[Abstract Not Available]Öğe EFFICIENCY OF DIRECT ORAL ANTICOAGULANTS ON ANTIPHOSPHOLIPID ANTIBODY SYNDROME: A CASE REPORT(Pergamon-Elsevier Science Ltd, 2016) Maden, M.; Umit, E. G.; Erdogan, S.; Demir, A. M.[Abstract Not Available]Öğe EVALUATION OF SARCOPENIA WITH HANDGRIP STRENGTH IN ADULT PATIENTS WITH CONGENITAL HEMOPHILIA(Wiley, 2020) Umit, E. G.; Bas, V.; Demirci, U.; Ekici, B.; Demir, A. M.[Abstract Not Available]Öğe Frailty in patients with acute myeloid leukaemia, conceptual misapprehension of chronological age(Wiley, 2018) Umit, E. G.; Baysal, M.; Demir, A. M.In haematology practice, patients with acute myeloid leukaemia (AML) are generally assessed for frailty only if they are older and not able to tolerate intensive and remission targeted treatments. We aimed to focus on frailty in patients with AML, in all ages and aimed to evaluate its role and practicality in daily routine. Data of patients diagnosed and treated for AML between 2006 and 2016 are recorded and assessed for their survival predictivity. One hundred and ninety-seven patients were <65years of age and 175 were 65. Majority of the younger patients showed ECOG 2 performance (119, 60.4%). Combined with ECOG scale, G8 scale showed survival predictivity in younger patients as well as older patients. Nutritional status showed a strong predictivity in younger patients while remained insignificant in older patients. VES13 scale showed similar predictivity strength for survival in both age groups (p=.001). Young AML patients should be thoroughly evaluated as older patients. ECOG performance evaluation should be supported with further scales. Young patients with lower ECOG scores may be regarded as vulnerable with scales embracing dimensions such as nutrition, perception of disease, depression and cognition. Nutrition should be within the main goals of intensive treatment and is related with survival.Öğe Helicobacter pylori and mean platelet volume: a relation way before immune thrombocytopenia?(Verduci Publisher, 2015) Umit, H.; Umit, E. G.OBJECTIVE: Helicobacter pylori is associated with chronic immune thrombocytopenia. Eradication of H. pylori has been related with a platelet response and this treatment has been included within management strategies for a certain group of patients. However, in patients with normal platelet counts, the effects of H. pylori infection on platelet count and mean platelet volume as an important platelet index have not been investigated. In this study, we aimed to assess the relation between platelet indices and H. pylori infection in patients with dyspepsia who have otherwise normal platelet counts. PATIENTS AND METHODS: In a retrospective manner, 4823 patients with dyspeptic complaints who have underwent an upper gastrointestinal endoscopy and a rapid urease test were included. Data of whole blood counts before the procedure were recorded from their files. Patients with normal endoscopic findings or simple gastritis were included. Patients with malignancy, GI bleeding, portal hypertension, liver or kidney disease and taking nonsteroidal anti-inflammatory drugs, proton pump inhibitors, cytotoxic medications were excluded. RESULTS: Mean platelet count in H. pylori positive and negative patients were 246381+/- 92225/mm(3) and 258135 +/- 89912/mm(3), respectively (p< 0.001). Mean MPV was higher in H. pylori positive group (8.9+/- 1.3 vs. 8.23 +/- 0.94, p< 0.001). This difference was observed in both genders. MPV was observed to be higher than 10 fL in 20.5% of HP positive patients while in only 2.8% of H. pylori negative patients (p< 0.0001). CONCLUSIONS: In patients with H. pylori infection and normal platelet counts, it may be speculated that an ongoing and compensated platelet destruction-production process may be responsible for the increase in MPV. Likewise, in conditions exclusive for the host or the H. pylori strain, platelet destruction may be enhanced leading to immune thrombocytopenia. As our study is the first study to investigate the effect of H. pylori in patients with normal platelet counts, our findings may give way to further prospective researches.Öğe LONGTERM OUTCOMES OF PHARMACOKINETIC BASED INDIVIDUALIZED PROPHYLAXIS IN PATIENTS WITH HEMOPHILIA A WITHOUT INHIBITORS(Wiley, 2023) Demir, A. M.; Demirci, U.; Umit, E. G.[Abstract Not Available]Öğe Next Generation Sequencing (NGS) in acute myeloid leukaemia: a centre experience(Springer, 2021) Oz Puyan, F.; Karaman Gulsaran, S.; Umit, E. G.; Usta, I.; Tastekin, E.; Can, N.; Kirkizlar, O.[Abstract Not Available]Öğe PET / CT Imaging in Smoldering Multiple Myeloma Patients F 18-Fluorodeoxyglucose and Ga68-Pentixafor: Preliminary results(Springer, 2020) Korkmaz, U.; Umit, E. G.; Durmus-Altun, G.[Abstract Not Available]Öğe A rare entity of primary cutaneous, extranodal NK/T-cell lymphoma, nasal type with loss of CD56 expression; Case report(Springer, 2017) Puyan, F. Oz; Umit, E. G.; Can, N.; Cezik, M.; Demir, A. M.; Kutlu, A. K.[Abstract Not Available]Öğe Screening for CALR gene mutations in Jak-2 V617F mutation negative patients with myeloproliferative neoplasms(Nature Publishing Group, 2018) Ulusal, S. Demir; Umit, E. G.; Gurkan, H.; Tozkir, H.; Baysal, M.; Goncu, E.; Eker, D.[Abstract Not Available]