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Study on Synthesis and Biological Activity of Some Pyridopyridazine Derivatives
(Slovensko Kemijsko Drustvo, 2018) Akcay, Sevilay; Ulger, Mahmut; Onurdag, Fatma Kaynak; Dundar, Yasemin
In this study, new pyrido [3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl) pyrido [3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido [3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.
SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF OFLOXACIN DERIVATIVES
(Editura Acad Romane, 2018) Dundar, Yasemin; Ulger, Mahmut; Kaynak Onurdag, Fatma; Okten, Suzan; Onkol, Tijen
A series of novel ofloxacin derivatives were prepared and screened for their antimycobacterial activity. Among the synthesized compounds, 2, 3, 18, 19, 26 exhibited significant antimycobacterial activity. Additionally, all synthesized compounds were evaluated for their antibacterial and antifungal activity.