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Öğe Association of eNOS Glu298Asp gene polymorphism with ischemic stroke in Turkish patients(Wiley-Blackwell, 2008) Guldiken, B.; Sipahi, T.; Guldiken, S.; Ustundag, S.; Turgut, N.; Budak, M.; Ozkan, H.[Abstract Not Available]Öğe Asymmetric dimethylarginine and nitric oxide levels in migraine during interictal period(Wiley-Blackwell, 2008) Guldiken, B.; Demir, M.; Guldiken, S.; Turgut, N.; Ozkan, H.; Kabayel, L.; Tugrul, A.[Abstract Not Available]Öğe Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period(Elsevier Sci Ltd, 2009) Guldiken, B.; Demir, M.; Guldiken, S.; Turgut, N.; Ozkan, H.; Kabayel, L.; Tugrul, A.Nitric oxide (NO), which modulates endothelial function, is thought to be pivotal in the pathophysiology of migraines. The connection between migraine and cardiovascular diseases has also drawn attention to the endothelial dysfunctions and NO pathway abnormalities seen in patients with migraine. Our goal was to assess the levels of NO and the endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), in people with migraine during the interictal period. A total of 49 patients with migraine and 22 control subjects were enrolled in the study. Their plasma NO metabolites (nitrite [NO2-] and nitrate [NO3-]) and ADMA levels were measured using the enzyme-linked immunosorbent assay method, and were then compared with their cardiovascular risk factors, anthropometric measurements, and headache frequency and severity. The plasma ADMA, NO2 and NO3 levels of the patients with migraine during the interictal period did not differ from the control group, and no relationship was found between cardiovascular risk factors and migraine attack severity and frequency. We conclude that, in patients with migraine, there is no dysfunction of baseline NO and ADMA metabolism during the interictal period. (C) 2008 Elsevier Ltd. All rights reserved.Öğe Changing cerebral blood flow velocity detected by transcranial Doppler ultrasound during head up tilt in patients with multiple sclerosis(Wiley-Blackwell, 2008) Gonul, M.; Asil, T.; Balci, K.; Celik, Y.; Turgut, N.; Uzunca, I.Background and purpose: Multiple sclerosis (MS) is a chronic inflammatory disease of central nervous system. We aimed to investigate the cerebral blood flow velocity (CBFV) changes in MS by transcranial Doppler. Methods: Twenty patients with MS, 20 age-matched healthy controls were included in the study. In both groups, blood flow velocities (BFVs) of middle cerebral arteries (MCAs) were evaluated. The changes of blood pressure, heart rate along with the changes in BFV of MCA were recorded after the patients were raised to upright position. Results: In both groups, upon raising the tilt table to the upright position, the mean CBFV values were found to be lower in comparison with the recorded baseline values (P values < 0.05). The decline in the mean CBFV values was more significant in patients with MS (P = 0.01). Conclusion: Our study showed upon raise of the tilt table, the mean BFVs decreased more in MS patients than control group with a more prominent change in the subgroup of MS patients with expanded disability scale scores >= 2. By use of transcranial Doppler ultrasound, it may be possible to evaluate BFV changes in patients with MS.Öğe Cortical disinhibition in diabetic patients with neuropathic pain(Wiley-Blackwell Publishing, Inc, 2009) Turgut, N.; Altun, B. U.Objectives - Motor cortex disinhibition has a role in the mechanism of neuropathic pain. The duration of the cortical silent period (CSP) is used as a measure of excitability in cortical inhibitory circuits. We investigated cortical disinhibition in diabetic patients with and without neuropathic pain. Materials and methods - We studied diabetic patients with (n = 20) and without (n = 50) neuropathic pain, and control subjects (n = 30). Transcranial magnetic stimulation (TMS) was performed on the right hemisphere at rest, and surface electromyography was recorded from the left first dorsal interosseous muscle for evaluation of motor evoked potential (MEP) latency and amplitude. CSP was recorded from the left FDI, and TMS was then delivered while the subject was performing a voluntary contraction. Results - We showed a low resting motor threshold, a short CSP duration, and a low CSP duration/MEP amplitude ratio in patients with neuropathic pain (P < 0.0001, P < 0.0001, P < 0.0001). Conclusions - Our findings demonstrate that diabetic patients with neuropathic pain have a cortical disinhibition.Öğe Development of entrapment neuropathies in acute stroke patients(Wiley, 2009) Kabayel, L.; Balci, K.; Turgut, N.; Kabayel, D. D.Stroke is the third most common cause of mortality and is one of the most common causes of morbidity in the world. Polyneuropathies and entrapment neuropathies are known as the complications of stroke. In this study we aimed to evaluate the development of entrapment neuropathies in severe stroke patients within the first month of the event. Twenty first-ever stroke patients were included in the study. The nerve conduction studies were performed within the first 48 h and repeated 1 month later. At the end of the first month, seven of the 20 patients had median nerve entrapment at the wrist, five had ulnar nerve entrapment at the elbow and seven had peroneal nerve entrapment at the fibular head in the hemiparetic side. Three patients had median nerve entrapment at the wrist, one patient had ulnar nerve entrapment at the elbow, and none had peroneal nerve entrapment in the non-paretic side. Our results confirm that, in severe hemiparetic patients, the entrapment neuropathies may be commonly seen, especially in the paretic extremities. The early rehabilitation programs against the development of entrapment neuropathies may be beneficial in stroke patients.Öğe INVESTIGATION OF COGNITIVE DYSFUNCTION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE(Wiley-Blackwell, 2011) Buyukkoyuncu, N.; Turgut, N.; Altiay, G.; Demir, M.; Karadag, H.; Turgut, B.; Caglar, T.[Abstract Not Available]Öğe Oxidative stress and antioxidant capacity in diabetic and non-diabetic acute ischemic stroke patients(Wiley-Blackwell, 2008) Guldiken, B.; Demir, M.; Guldiken, S.; Turgut, N.; Turgut, B.; Tugrul, A.[Abstract Not Available]Öğe Polymorphisms of the angiotensin-converting enzyme and angiotensin II receptor type 1 genes and association with stroke in Turkish subjects of the Trakya region(Wiley-Blackwell, 2008) Sipahi, T.; Guldiken, B.; Budak, M.; Guldiken, S.; Ustundag, S.; Turgut, N.; Ozkan, H.[Abstract Not Available]Öğe Relationship between total anti-oxidant capacity, homocysteine levels and cognitive tests in patients with amyotrophic lateral sclerosis(Wiley-Blackwell, 2012) Kat, S.; Turgut, N.; Guldiken, B.; Demir, M.; Erbas, H.; Turgut, B.[Abstract Not Available]Öğe Soluble CD40 ligand and prolactin levels in migraine patients during the interictal period(Wiley-Blackwell, 2010) Guldiken, S.; Guldiken, B.; Demir, M.; Kabayel, L.; Ozkan, H.; Turgut, N.; Hunkar, R.[Abstract Not Available]