Yazar "Turan, Pinar" seçeneğine göre listele
Listeleniyor 1 - 3 / 3
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Analysis of the Patients with Sepsis Caused by Gram Positive and Gram Negative Bacteria(Ortadogu Ad Pres & Publ Co, 2008) Turan, Pinar; Tansel, Oezlem; Ekuklu, Galip; Celik, Ayguel DoganObjective: The objective of this study was to evaluate the epidemiological, clinical, laboratory features and risk factors associated with mortality of the 109 adult cases of sepsis in which gram positive, and gram negative bacteria isolated from blood cultures. Material and Methods: One hundred and nine patients with sepsis followed in our hospital between January 2002 and January 2003 were investigated prospectively. Results: Gram negative bacteria were isolated from blood cultures in the rate of 58.7%. The most frequent gram negative bacterium was Escherichia coli, and gram positive was Staphylococcus aureus. Statistically significant difference was not detected between gram positive, and gram negative bacteria sepsis related with development of hypothermia, appropriate antibiotic treatment, septic shock, multiple organ dysfunction syndrome (MODS), disseminated intravascular coagulation (DIC), and mortality rate. The mortality rate was 23%. The risk factors related with mortality were old age, hypothermia, staying in intensive care units, changes in consciousness, septic shock, MODS, DIC, renal failure, acute respiratory distress syndrome (ARDS), inappropriate antibiotherapy, and lack of infectious disease specialist consultation. Inappropriate antibiotic therapy, severe sepsis, and old age were found as independent factors in mortality by logistic regression analysis. Conclusion: There was no significant difference between the risk factors of gram positive, and gram negative bacteria sepsis. Prompt diagnosis and appropriate antibiotic treatment was important in decreasing the mortality in both of them.Öğe Effects of Intratympanic Steroid on Cisplatin Ototoxicity: An Electrophysiological and Ultrastructural Study(Akad Doktorlar Yayinevi, 2018) Tas, Abdullah; Bulut, Erdogan; Tas, Memduha; Yagiz, Recep; Turan, Pinar; Huseyinoglu, Aydin; Karasalihoglu, Ahmet R.Ototoxicity refers to the inner ear dysfunction caused by a drug or a chemical agent which manifests as hearing loss or balance impairment, or both. Currently, antibiotics, diuretics, anti-inflammatory drugs, antineoplastic agents, antimalarial drugs and some other agents are known to cause ototoxicity. Cisplatin is an antineoplastic agent for which the ototoxicity incidence may vary based on the treatment protocol. In the present study, we aimed to perform an electrophysiological and ultrastructural evaluation regarding the protective effectiveness of intratympanic steroids on cisplatin ototoxicity. Electrophysiological assessment included tympanometry and auditory brainstem response (ABR), and 16 guinea pigs (32 ears) with normal hearing were randomly assigned to 4 groups as follows: control, cisplatin, cisplatin/steroid and cisplatin/physiological saline. Following the electrophysiological measurements, temporal bones were dissected for ultrastructural examinations. In the cisplatin group, a statistically significant (p<0.05) threshold difference was noted for the ABR test versus the other groups while this threshold difference was lower in the cisplatin/steroid group compared to the other groups. Ultrastructural evaluations revealed abnormal outer hair cell stereocilia morphology and severe degenerative changes in the cisplatin and cisplatin/physiological saline groups. Mild degenerative alterations were seen in the outer hair cell stereocilia morphology in the guinea pig cochlea administered with intratympanic steroid. We believe intratympanic steroid administration showed protective effectiveness on the cisplatin-induced ototoxic damage in our study.Öğe A New Hypothesis on the Frequency Discrimination of the Cochlea(Aves, 2017) Bulut, Erdogan; Uzun, Cem; Ozturk, Levent; Turan, Pinar; Kanter, Mehmet; Arbak, SerapOBJECTIVE: Medial olivocochlear efferent (MOCE) neurons innervate outer hair cells (OHCs) of the cochlea, which in turn leads to basilar membrane motion. We hypothesized that MOCE-induced alterations in basilar membrane motion, independent of traveling waves, is responsible for the cochlear frequency discrimination of sound. MATERIALS and METHODS: Eleven guinea pigs underwent bilateral otoscopic and audiologic evaluations under general anesthesia. The study comprised two parts. Part I (n=11) included spontaneous otoacoustic emission (SOAE) recordings with or without contralateral pure-tone acoustic stimuli (1 and 8 kHz) at 60 dB sound pressure level (SPL). Part II involved pure-tone (1 or 8 kHz) acoustic trauma in the right ears of two randomly selected subgroups (G1: 1 kHz; n=4 and G8: 8 kHz; n=4). The remaining three animals served as controls. After frequency-specific deafness was confirmed by distortion product otoacoustic emission (DPOAE), SOAEs were recorded in the left ears in the presence of a contralateral pure-tone (1 and 8 kHz) stimulus of 60 dB SPL. Furthermore, the surface of the organ of Corti was examined by scanning electron microscopy (SEM). RESULTS: The contralateral pure tone led to frequency-specific activation in SOAEs in part I (without trauma) and part II (with trauma) measurements. SEM showed heterogeneous OHC damage along the cochlea in traumatized ears with pure tone. CONCLUSION: We suggest that MOCEs convey acoustic information from traumatized ears to intact ears. Traumatized ears can show frequency-specific activation in the presence of diffuse damage in OHCs that excludes the passive transmission of the pressure wave from the perilymph to the basilar membrane.