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Öğe Adaptation of Parental Self-Efficacy Scale for Child Autonomy Toward Minor Surgery to Turkish(Elsevier Science Inc, 2022) Semerci, Remziye; Unver, Seher; Topcu, Sacide Yildizeli; Turan, Fatma Nesrin; Kostak, Melahat Akgun; Findik, Ummu YildizPurpose: The purpose of the study was to conduct validity and reliability testing of the Turkish version of the Parent Self-Efficacy Scale for Child Autonomy toward Minor Surgery (PSESCAMS). Design: The research is a methodological study. Methods: Data were collected using an Introductory Form and the PSESCAMS. Factor analysis, Cronbach's alpha, and item-total score analysis were used for the data analysis. Findings: The scale consisted of 18 items and four subscales. The Cronbach's alpha coefficient for the overall scale was 0.95, and the Cronbach's alpha values for the subscales were 0.64-0.92. The total factor loading was > 0.45 for both exploratory and confirmatory factor analyses. GFI, AGFI, and CFI were > 0.90, RMSEA was 0.06. Conclusion: PSESCAMS was found to be a valid and reliable measurement tool for Turkish culture. (c) 2021 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.Öğe Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis(Zamensalamati Publ Co, 2015) Akdere, Hakan; Oztekin, Ilhan; Arda, Ersan; Aktoz, Tevfik; Turan, Fatma Nesrin; Burgazli, Kamil MehmetBackground: Chronic Nonbacterial Prostatitis (CNBP) is a condition that frequently causes long-term pain and a significant decrease in the quality of life. Objectives: The present study aimed to examine the analgesic effects of oligonol, acupuncture, quantum light therapy and their combinations on estrogen-induced CNBP in rats. Materials and Methods: This experimental study was conducted in Edirne, Turkey, using a simple randomized allocation. A total of 90 adult male Wistar rats were randomized into 9 groups of 10 rats each: Group I, control; Group II, CNBP, Group III, oligonol only, Group IV, acupuncture only; Group V, quantum only; Group VI, oligonol + quantum; Group VII, acupuncture + oligonol; Group VIII, quantum + acupuncture; Group IX, acupuncture + quantum + oligonol. Oligonol treatment was given at a dose of 60 mg/ day for 6 weeks. Conceptual vessels (CV) 3 and 4, and bilaterally urinary bladder (Bl) 32 and 34 points were targeted with 1-hour acupuncture stimulation. The quantum light therapy was applied in 5-minute sessions for 6 weeks (3-times/a week). For pain measurements, mechanical pressure was applied to a point 2 cm distal to the root of the tail to elicit pain and consequent parameters (peak force, latency time of response and total length of measurement) were assessed. Results: Analgesic effects were observed with all treatment regimens; however, the most prominent median analgesic effect was shown in the quantum light therapy in combination with acupuncture for estrogen-induced CNBP (PF1 = 663.9, PF2 = 403.4) (P = 0.012). Furthermore, we observed that monotherapy with quantum light showed a better analgesic efficacy as compared to oligonol and acupuncture monotherapies (PF1 = 1044.6, PF2 = 661.2) (P = 0.018, P = 0.008, P = 0.018; respectively). Conclusions: All treatment modalities showed a significant analgesic effect on CNBP in rats, being most prominent with the quantum light therapy.Öğe The analysis of the risk factors observed in patients with hip fracture(Galenos Publ House, 2011) Copuroglu, Cem; Unver, Kagan Volkan; Ozcan, Mert; Ciftdemir, Mert; Turan, Fatma Nesrin; Copuroglu, ElifObjective: Hip fractures are frequently seen in the elderly and an important reason of morbidity and mortality. We aimed to analyze the accompanying risk factors of the hip fractured patients who have been treated in our university clinic. Material and Methods: The data of 180 patients, who have been treated in our clinic between December 2008 and July 2010, were evaluated. The preoperative activity level of the patients, fracture type, mechanism of injury and patients' co morbid medical diseases were evaluated and compared with preoperative biochemical markers statistically. Results: The study group included 180 patients (72 male, 108 female) with a mean age of 73.9 (24-103). One hundred eighteen of the patients admitted because of intertrochanteric femur fracture, 54 because of femoral neck fractures and 8 because of subtrochanteric femur fractures. Forty-three (24%) patients had no medical co morbidity while 22 had hypertension, 10 had cancer, 7 had cardiac disease, 6 had diabetes mellitus and 75 (42%) had more than one accompanying co morbidity. Conclusion: Mostly low energy injuries cause osteoporotic fractures in women and medical co morbidities also exist. In order to decrease the morbidity and the mortality of the hip fractures, metabolic disorders should be taken under control simultaneously with the fracture treatment.Öğe Assessment of ventricular and left atrial mechanical functions, atrial electromechanical delay and P wave dispersion in patients with scleroderma(Via Medica, 2011) Aktoz, Meryem; Yilmaztepe, Mustafa; Tatli, Ersan; Turan, Fatma Nesrin; Umit, Elif G.; Altun, ArmaganBackground: The aim of this study was to investigate ventricular functions and left atrial (LA) mechanical functions, atrial electromechanical coupling, and P wave dispersion in scleroderma patients. Methods: Twenty-six patients with scleroderma and twenty-four controls were included. Left and right ventricular (LV and RV) functions were evaluated using conventional echocardiography and tissue Doppler imaging (TDI). LA volumes were measured using the biplane area-length method and LA mechanical function parameters were calculated. Inter-intraatrial electromechanical delays were measured by TDI. P wave dispersion was calculated by 12-lead electrocardiograms. Results: LV myocardial performance indices (MPI) and RV MPI were higher in patients with scleroderma (p = 0.000, p = 0.000, respectively) while LA passive emptying fraction was decreased and LA active emptying fraction was increased (p = 0.051, p = 0.000, respectively). P wave dispersion and inter-intraatrial electromechanical delay were significantly higher in patients with scleroderma (25 [10-60] vs 20[0-30], p = 0.000, 16.50 [7.28-26.38] vs 9.44 [3.79-15.78] and 11.33 [4.88-16.06] vs 4.00 [0-12.90], p < 0.05, respectively). Interatrial electromechanical delay was negatively correlated with LV E wave, (p = 0.018). LV E wave was demonstrated to be a factor independent of the interatrial electromechanical delay (R(2) = 0.270, beta = -0.52, p = 0.013). Conclusions: This study showed that in scleroderma patients, global functions of LV, RV and mechanical functions of LA were impaired, intra-interatrial electromechanical delays were prolonged and P wave dispersion was higher. LV E wave was demonstrated to be a factor that is independent of the interatrial electromechanical delay. Reduced LV E wave may also give additional information on the process of risk stratification of atrial fibrillation. (Cardiol J 2011; 18, 3: 261-269)Öğe Asymmetrical dimethylarginine and severity of erectile dysfunction and their impact on cardiovascular events in patients with acute coronary syndrome(Termedia Publishing House Ltd, 2010) Aktoz, Meryem; Aktoz, Tevfik; Tatli, Ersan; Kaplan, Mustafa; Turan, Fatma Nesrin; Barutcu, Ahmet; Atakan, Irfan HueseyinIntroduction: Coronary artery disease (CAD) and vascular erectile dysfunction (ED) are related to endothelial dysfunction. Elevated asymmetrical dimethylarginine (ADMA) levels and ED are common in patients with increased cardiovascular risk. Our aim was to investigate whether ADMA has a predictive role for major adverse cardiovascular events (MACE) in acute coronary syndrome (ACS). The secondary aim of this study was to investigate whether severity of ED predicts MACE in these patients. Material and methods: Follow-up data were available for severity of ED in 71 patients with ACS. Plasma ADMA levels were determined by ELISA in 57 patients. Erectile dysfunction was assessed by the International Index of Erectile Function-6 (IIEF-6) score. Major adverse cardiovascular events (reinfarction, all-cause hospitalisation, stroke and all-cause death) was evaluated after a median of 10 months. Results: Severe ED had no significantly increased hazard ratio for cardiovascular events compared with mild, mild to moderate, and moderate ED (0.259 [95% CI 0.041-1.6], p = 0.147; 0.605 [95% CI 0.095-3.8], p = 0.594; 0.980 [95% CI 0.233-4.1], p = 0.978; and 0.473 [95% CI 0.052-1.3], p = 0.508). The patients who had ADMA levels 0.32 mu mol/l had no significantly increased hazard ratio for cardiovascular events compared with patients who had ADMA levels < 0.32 mu mol/l (2.018 [95% CI 0.615-6.6], p = 0.247). Conclusions: Severity of ED and ADMA did not increase the risk of cardiovascular events in follow-up patients with ACS in our study. Larger prospective studies are necessary to evaluate whether ADMA predicts cardiovascular events in patients with ACS.Öğe Avoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Study(Soc Brasil Cirurgia Cardiovasc, 2017) Huseyin, Serhat; Guclu, Orkut; Yuksel, Volkan; Erkul, Gulen Sezer Alptekin; Can, Nuray; Turan, Fatma Nesrin; Canbaz, SuatObjective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat aorta. Methods: 32 Sprague-Dawley female rats were randomized into four groups (n=8). Ischemia was induced with infrarenal aortic cross-clamping for 60 minutes; then the clamp was removed and reperfusion was allowed for 120 minutes. While the control group and the ischemia-reperfusion group did not receive any supplementary agent, two other groups received vitamin C and papaverine hydrochloride (papaverine HCL). Liver tissues were evaluated under the light microscope. Histopathological examination was assessed by Suzuki's criteria and results were compared between groups. Results: In ischemia-reperfusion group, severe congestion, severe cytoplasmic vacuolization, and parenchymal necrosis over 60% (score 4) were observed. In vitamin C group, mild congestion, mild cytoplasmic vacuolization and parenchymal necrosis below 30% (score 2) were found. In papaverine group, moderate congestion, moderate cytoplasmic vacuolization and parenchymal necrosis below 60% (score 3) were observed. Conclusion: An ischemia of 60 minutes induced on lower extremities causes damaging effects on hepatic tissue. Vitamin C and papaverine are helpful in reducing liver injury after acute ischemia reperfusion and may partially avoid related negative conditions.Öğe The Better Performance Status, the Better Outcome: Laryngeal Carcinoma Treated with Definitive Radiotherapy(B C Decker Inc, 2008) Yurut-Caloglu, Vuslat; Caloglu, Murat; Turan, Fatma Nesrin; Ibis, Kamuran; Karagol, Hakan; Kocak, Zafer; Uzal, CemPurpose: To evaluate the prognostic factors affecting locoregional control (LRC) and overall survival (OS) of patients with laryngeal carcinoma who were not candidates for surgical treatment due to tumour or host factors but were treated with definitive radiotherapy (RT). Patients and Methods: Sixty-three consecutive patients, treated with definitive RT between 1999 and 2005, were retrospectively analyzed. All patients had histologically proven squamous cell carcinomas of the larynx. The median age was 62 years (range 43-83 years). Follow-up ranged from 22 days to 68 months (median 32 months). Results: The LRC rates at 2 and 5 years were 70% and 48%. The 2- and 5-year OS rates were 65% and 40%. No statistically significant relationship was found between World Health Organization performance status score (WHO PS) and age (p = .21), tumour site (p = .42), overall stage (p = .11), T stage (p = .19), and N stage (p = .69). Multivariate analyses showed that a WHO PS score >= 2 (p < .0001) and RT treatment time >= 50 days (p = .0172) significantly decreased LRC. Moreover, a WHO PS score >= 2 (p < .0001), RT treatment time >= 50 days (p = .0138), and RT dose < 66 Gy (p = .04) were significantly negative prognostic factors on OS. Conclusion: Definitive RT, in patients with early- and more advanced-stage squamous cell carcinoma of the larynx, is an important treatment option. It is clear that patients with good pretreatment PS would get better results from definitive RT.Öğe Comparison of early period results of blood use in open heart surgery(Medknow Publications & Media Pvt Ltd, 2016) Huseyin, Serhat; Yuksel, Volkan; Guclu, Orkut; Turan, Fatma Nesrin; Canbaz, Suat; Ege, Turan; Sunar, HasanBackground: Various adverse effects of homologous blood transfusion detected particularly in open heart surgery, in which it is frequently used, lead researchers to study on autologous blood use and to evaluate the patient's blood better. Due to the complications of homologous blood transfusion, development of techniques that utilize less transfusion has become inevitable. We aimed to evaluate the effects of acute normovolemic hemodilution (ANH) in patients undergoing open heart surgery. Materials and Methods: In this study, 120 patients who underwent open heart surgery were included. Patients were grouped into three: Autologous transfusion group (Group 1), homologous transfusion group (Group 2), and those received autologous blood and homologous blood products (Group 3). Patient data regarding preoperative characteristics, biochemical parameters, drainage, extubation time, duration of stay at intensive care, atrial fibrillation (AF) development, and hospital stay were recorded. Results: A statistically significant difference (P < 0.005) was found in favor of autologous group (Group 1) with respect to gender, body surface area, European System for Cardiac Operative Risk Evaluation, smoking, hematocrit levels, platelet counts, urea, C-reactive protein levels, protamine use, postoperative drainage, frequency of AF development, intubation period, stay at intensive care and hospital stay, and amount of used blood products. Conclusion: The use of autologous blood rather than homologous transfusion is not only attenuates side effects and complications of transfusion but also positively affects postoperative recovery process. Therefore, ANH can be considered as an easy, effective, and cheap technique during open heart surgery.Öğe Comparison of Lumbar Disc Herniation and Degeneration Relationship with the Sagittal Morphology of the Spine(Derman Medical Publ, 2015) Delen, Emre; Birgili, Bans; Akinci, Ahmet Tolgay; Karabulut, Derya; Turan, Fatma Nesrin; Kunduracilar, Nebile Muge; Memis, Muzafferin this study, the relationship between the lower intervertebral disc herniation and the degeneration of the spine with the sagittal morphological values were investigated. The data on this study is obtained retrospectively from patients who were operated in our center with the diagnosis of lower level lumbar disc herniation. A total of 117 patients, 75 female and 42 male are included. Patients are divided into two groups as with degeneration (Pfirmann stage III-IV-V) and without degeneration (Pfirmann stage I-II). Among 117 patients, 13 were in the with degeneration group, while 104 were in the without degeneration group. The mean age of the first group was 43.0 (+/- 11.2) years, while the second group had a mean age of 45.3 (+/- 11.4) years and there were not a statistically significant differences between them (P > 0.05). Mean lumbar lordosis angle was 23.30 (+/- 8.92) degree in the first group and 28.81 (+/- 9.17) degree in the without dejeneration group, thus a lower degree was observed in the group with degeneration (P = 0.050). Segmental lordosis angle was 24.69 (+/- 8.91) and 28.17 (+/- 5.75) degree respectively, in the group with degeneration the angle value was lower (P = 0.088). The sacral surface angle in the group with degeneration was 99.51 (+/- 5.36) degree and in the second group it was 100.56 (+/- 6.03) degree. Nevertheless the difference was not statistically significant (P = 0.509). The sacral kyphosis angle is determined as 170.13 (+/- 5.41) degree and 155.59 (+/- 45.96) degree in the two groups respectively and there was statistically significant difference between them (P = 0.059). For cases with lower level lumbar disc herniation there exists a significant relationship between the disc herniation and degeneration, therefore the lumbar lordosis and the segmental lordosis angles are lower in patients with degeneration.Öğe Comparison of quality of life in different regions of musculoskeletal diseases(Turkey Assoc Physiotherapists, 2008) Ozdinc, Sevgi Anar; Kokino, Sirenus; Hakguder, Aral; Gezici, Buket; Turan, Fatma NesrinPurpose: The aim of this study was to compare demographic characteristics and quality of life In patients with musculoskeletal system disorders localized in various regions. Material and methods: Nottingham Health Profile (NHP) was applied in order to measure life qualities of the patients and a questionnaire of personal information was given. Among these patients, 3 different groups were formed as low back, neck and multi-involved and they were compared with respect to NHP. Binary comparisons were performed in parameters which demonstrated a difference. Demographic properties, exercise habits and pain seventy that is measured with visual analog scale were taken down. Low back pain, neck and multi-involved patient group's results were compared. Results: A difference was found In age and occupation distribution in the sub-groups with respect to demographic features (p<0.05). A difference was found in physical mobility and pain parameters when NHP was considered (p<0.05). Both parameters were worse in low back and multi involved groups compared to the neck group. Fatigue and social isolation were better in patients having exercising habits (p<0.05). Conclusion: The region of the musculoskeletal system disease, age, BMI, pain severity, education, presence of a systemic disease, gender and exercising habits may affect life quality.Öğe Determining the efficiency of different malnutrition tests in septic patients(Reial Acad Medicina Illes Balears, 2021) Inal, Mehmet Turan; Memis, Dilek; Tek, Seyda Cigdem; Uyar, Ahmet Senol; Ozel, Muhammet Fatih; Ciftci, Taner; Turan, Fatma NesrinBackground and aims: Malnutrition is frequently detected in septic patients and is important cause of mortality. Methods: Numerical rating Scale 2002, Nutrition risk in the critically ill score and adductor pollicis thickness measurement are used to determine malnutrition in 287 septic patients. Results: The mean age was 66,57 +/- 16,31 years. The mean APACHE II score was 16,19 +/- 8,20 while the mean SOFA score was 5,89 +/- 3,49. To NRS 2002 test 171 was accepted as high malnutrition risk while 116 patients was accepted as low malnutrition risk. According to Nutric test, the risk of malnutrition was found to be low in 144 patients and found to be high in 143 patients. The mean APTM was detected as 20,20 +/- 2,21 mm. The cuff-off point for APTM was found as <= 21 mm. Conclusions: high risk of malnutrition was frequently observed in patients with sepsis and mortality was higher in high risk patients. Higher sensitivity was achieved when the tests were combined with each other. As a result, we recommend the use of malnutrition screening tests in patients with sepsis and combining the tests with each other.Öğe Development of a New and Simple Postoperative Pain Fear Scale for Elective Surgeries in Adult Patients(Galenos Yayincilik, 2021) Unver, Seher; Turan, Fatma NesrinAim: There is a need to assess the pain fear levels of surgical patients simply and appropriately before the surgery. This study aimed to develop and test the psychometrics of an instrument to evaluate the fear of postoperative pain. Methods: This methodological study was conducted at four surgical clinics including general surgery, orthopedics and traumatology, neurosurgery, heart and vessel surgery of a university hospital between 28 March and 19 October 2018. Totally, 150 patients who were scheduled for elective surgery and at their preoperative day were included. This scale contained 10 items related to the postoperative pain sources and aimed to identify the pain fear of patients preoperatively. To measure the sampling adequacy, Kaiser-Meyer-Olkin index and Bartlett's test of sphericity was used. Explanatory and confirmatory factor analyses were conducted to evaluate the construct validity. The internal consistency of the scale was evaluated by Cronbach's alpha calculation. All hypotheses were tested in two directions. Results: The total variance explained 55.5% of the variance for one factor structure consisting of 10 items. The model fit index values through the confirmatory factor analysis were found to support this structure. Conclusion: The scale is appropriate to be used in clinical settings to quickly evaluate the elective surgical patients' fear level of postoperative pain preoperatively.Öğe Devlet hastanesinde çalışan sağlık personelinin tükenmişlik düzeyleri(2008) Faikoğlu, Rehat; Turan, Fatma Nesrin; Şahin, İbrahim; Alparslan, Neşe; Şahin, Derya; Görgülü, AdnanAmaç: Tükenmişlik sendromu; işi gereği insanlarla yoğun ilişki içerisinde olan insanlarda görülen “duygusal tükenme, duyarsızlaşma ve kişisel başarı hissinin kaybı” şeklinde 3 boyutu olan bir sendromdur. Sağlık çalışanları tükenmişlikle karşılaşan meslek gruplarından birisidir. Araştırmamızın amacı Kırklareli Devlet Hastanesinde çalışan sağlık personelinin (hemşire/sağlık memuru/ebe) tükenmişlik düzeyini ve etkileyen değişkenleri belirlemektir. Yöntem: Tanımlayıcı tipteki bu çalışma 2006 yılı Kasım ayında Kırklareli İl Merkez Devlet Hastanesi’nde çalışan hemşire, sağlık memuru ve ebelerden oluşan 150 sağlık personeli üzerinde planlanmış; ancak 107 kişiye ulaşılabilmiştir. Veriler; personelin sosyo-demografik özellikleri, aile ve iş yaşamlarına yönelik olarak hazırlanmış 20 soruluk anket formu ve Maslach Tükenmişlik Ölçeği (MTÖ) kullanılarak yüz yüze görüşme yöntemi ile toplandı. Bulgular: Araştırmaya katılan personelin yaş ortalaması kadınlarda 34.51±6.06, erkeklerde 30.90±4.40 olup; çalışma grubundaki personelin %54’ü hemşire (n=58), %36’sı ebe (n=38) ve %10’u (n=11) sağlık memurudur. Çalışma grubunun duygusal tükenmişlik puan ortalamaları 18.76±10.21, duyarsızlaşma alt ölçeğinin puan ortalamaları 4.17±3.90, kişisel başarısızlık alt ölçeğinin puan ortalamaları 36.80±7.91 olarak belirlenmiştir. Cinsiyetlerine, yaş gruplarına, eğitim durumlarına, aile tiplerine, çalışma süresine, sağlık sorunlarının var olma durumlarına göre tükenmişlik puanları arasındaki ilişkinin önemli olmadığı bulunmuştur ve MTÖ puanını etkilememektedir. Sonuç: Kırklareli Devlet Hastanesi sağlık personelinin (ebe-hemşire-sağlık memuru) tükenmişlik düzeyi düşük olarak saptanmıştırÖğe Does an abnormal infrapatellar plica increase the risk of chondral damage in the knee(Springer, 2011) Ozcan, Mert; Copuroglu, Cem; Ciftdemir, Mert; Turan, Fatma Nesrin; Calpur, Osman UgurThe aim of this study was to evaluate abnormal infrapatellar plicae that cause chondral lesions on the patellofemoral sulcus and superior aspect of intercondylar notch. In this study, 133 abnormal infrapatellar plicae were evaluated. The abnormal infrapatellar plicae may lead to chondral lesions on the superior portion of intercondylar notch and on the inferior portion of the patellofemoral sulcus with striking, friction, and compression forces during knee motion. The chondral lesions that were caused by abnormal infrapatellar plicae were more severe than the chondral lesions that were caused by normal infrapatellar plicae. The width of the plica did not affect the severity of chondral lesions. Abnormal infrapatellar plicae might be one of the causes of chondral lesions on the superior portion of intercondylar notch and on the patellofemoral sulcus. The width of the plica did not affect the severity of chondral lesions.Öğe Effects of ballet training of children in Turkey on foot anthropometric measurements and medial longitudinal arc development(Pakistan Medical Assoc, 2016) Ozdinc, Sevgi Anar; Turan, Fatma NesrinObjective: To investigate the effects of ballet training on foot structure and the formation of the medial longitudinal arc in childhood, and the association of body mass index with structural change secondary to ballet training. Methods: This study was conducted at Oyku Ballet and Dance School and Trakya University, Edirne, Turkey, from September 2007 to November 2008, and comprised girl students who were taking ballet classes, and a group of those who were not taking such who acted as the controls. Static footprints of both feet of all participants were taken with an ink paedogram. Parameters evaluated from footprints included foot length, metatarsal width, heel width and medial longitudinal arch. The relationship between the parameters, the ballet starting age, training duration and body mass index was investigated. Results: Of the 67 participants, there were 36(53.7%) in the experimental group and 31(48.3%) in the control group. The difference between age, height, weight and body mass index between the two groups was insignificant (p>0.05). The average ballet starting age was 6.47 +/- 1.55 years and duration was 4.36 +/- 2.002 years. Positive correlations were found between body mass index and foot length, metatarsal width, heel width, medial longitudinal arch contact width and halluxvalgus angle; between ballet starting age and metatarsal width, heel width; between duration of training and foot length, metatarsal width and hallux valgus angle (p?0.05 each). Conclusion: Evidence supporting the effect of ballet education in children on foot anthropometric measurements and medial longitudinal arc development could not be found.Öğe Effects of high fructose diet and exercise on glucose transporter 5 and putative glycerol-transporter aquaporin 7 in the in vivo rat heart(Wiley-Blackwell, 2015) Karaca, Aziz; Vardar, Selma Arzu; Palabiyik, Orkide; Tastekin, Ebru; Turan, Fatma Nesrin[Abstract Not Available]Öğe Evaluating superiority, 'equivalence and non-inferiority in clinical trials(K Faisal Spec Hosp Res Centre, 2007) Turan, Fatma Nesrin; Senocak, MustafaClinical studies are usually performed with the aim of justifying that a new treatment approach is superior to the common standard approach (active control) with respect to benefits. In a general sense, this justification is carried out on the basis of the null hypothesis significance test with the P value based on this test used for justification. Today, new drugs differ so little from existing ones that factors such as cost and side effects affect the choice of therapy, when the bioavailability of treatment methods are found equivalent. Therefore, the aim of comparative clinical trials has extended beyond showing that a treatment is superior and now attempts to show that new treatments are equal and non-inferior to existing treatments. New approaches have become necessary since the classical null hypothesis approach is insufficient to justify the use of new agents, especially in cases of equivalence and non-inferiority. This new approach to justification makes use of the clinical equivalence interval, which determines the limits of the differences between specific endpoints that can be regarded as clinically equal to the value that was pre-specified based on studies of established therapies. It also makes use of the quantitative-based confidence intervals as the criteria for statistical justification. Many analyses can be done confidently when these tools are applied and the data are interpreted correctly.Öğe Farklı bölge kas iskelet sistemi hastalıklarında yaşam kalitesinin karşılaştırılması(2008) Özdinç, Anar Sevgi; Kokino, Sirenuş; Hakgüder, Aral; Gezici, Buket; Turan, Fatma NesrinAmaç: Bu çalışmada, farklı bölgelerde lokalize olan kas iskelet sistemi problemlerinin yaşam kalitesi üzerindeki etkileri ile demografik özellikleri karşılaştırmak amaçlandı. Gereç ve yöntem: Çalışmaya kas iskelet sistemi problemi olan 171 hasta katıldı. Yaşam kalitesini ölçmek amacıyla Nottingham Sağlık Profili ve kişisel bilgileri içeren bir anket uygulandı. Demografik özellikler, egzersiz alışkanlığı ve görsel analog skalası kullanılarak ölçülen ağrı şiddeti kaydedildi. Bel, boyun ve çoklu tutulumu olan hastaların sonuçları karşılaştırıldı. Sonuçlar: Gruplar arasında yaş ve meslek dağılımı, Nottingham Sağlık Profili, fiziksel mobilite ve ağrı parametrelerinde istatistiksel olarak anlamlı bir fark olduğu saptandı (p<0.05). Her iki parametrede bel ve çoklu tutulum grubunda daha kötüydü. Egzersiz alışkanlığı olanlarda yorgunluk ve sosyal izolasyon parametreleri daha iyi bulundu (p<0.05). Tartışma: Kas iskelet sistemi hastalıklarında etkilenen bölge, yaş, beden kütle indeksi, ağrı şiddeti, eğitim, sistemik hastalık varlığı, cinsiyet ve egzersiz alışkanlığı, yaşam kalitesini etkileyebilmektedir.Öğe Fizyoterapi ve Rehabilitasyon Eğitimi Alan Lisans Öğrencilerinin Mesleki Kaygı Düzeylerinin Belirlenmesi(2018) Özdinç, Sevgi; Biçici, Yağmur; Çamur, Miraç; Turan, Fatma NesrinBu çalışmanın amacı, fizyoterapi ve rehabilitasyon bölümü öğrencilerinin mezuniyet sonrasına yönelik mesleki kaygılarını belirlemektir.Ayrıca bölüme yeni başlayan birinci sınıflar ile mezun aşamasındaki son sınıfları mesleki kaygı açısından karşılaştırmaktır. 2016-2017öğretim döneminde fizyoterapi bölümü birinci ve son sınıf öğrencilerine, araştırmacılar tarafından geliştirilen mesleki kaygı anketi iledurumluk ve süreklilik kaygı ölçeği 1-2 (State-Trait Anxiety Inventory – STAI TX 1-2) uygulandı. Kesitsel ve tanımlayıcı olarak planlananaraştırmada her üç ölçek açısından cinsiyet ve sınıflar arası fark araştırıldı. Her üç ölçek açısından cinsiyetler arasında istatistiksel farktespit edilemezken, mesleki kaygı maddeleri açısından sınıflar arasında fark tespit edilmiştir (p>0.05). Birinci sınıflarda mesleki yeterliğeyönelik kaygı yüksek iken dördüncü sınıflarda gelecek ve iş bulma kaygısı daha yüksek bulundu (p>0.05). Çalışmamızda, eğitim sürecininöğrencilerin öz yeterliliklerini desteklemesini memnun edici bulduk. Dördüncü sınıfta artan gelecek ve iş bulma kaygılarının azaltılmasıiçin kariyer günleri gibi faaliyetlerin artırılmasının yararı olacağını düşünmekteyiz.Öğe Geriyatrik acil olgularda albumin düzeyinin derlenme ve hospitalizasyon süresine etkileri(2005) Arar, Cavidan; Alagöl, Ayşin; Kaya, Gaye; Günday, Işıl; Turan, Fatma NesrinAmaç: Bazı çalışmalar elektif cerrahi öncesi albumin düzeyinin postoperatif derlenme, morbidite ve mortaliteyi etkilediğini bildirmektedir. İleri yaş, postoperatif dönemde daha da önem kazanmaktadır. Bu retrospektif çalışmada geriyatrik yaş grubundan, genel anestezi altında acil cerrahi geçirmiş 40 olgunun preoperatif albumin düzeyinin derlenme, postoperatif hastanede yatış süresi ve taburcu edilme koşulları üzerine etkilerini araştırdık.Gereç ve Yöntem: Preoperatif albumin düzeyine göre hastalar Grup I, albumin > 3.5 g dL-1 (n=20), Grup II, albumin <3.5 g dL-1 (n=20) olarak belirlendi. Bu çalışmaya aynı anestezi planı uygulanacak hastalar dahil edildi. Anesteziden uyanma kriterleri (anestezi bitimi ile göz açma, ekstübasyon, verbal uyarılara yanıt ve oryantasyon için geçen süre), postoperatif komplikasyonlar, hastanede kalış süreleri ve taburcu edilme koşulları saptandı.Bulgular: Gruplar arasında preoperatif yönden farklılık yoktu (p>0 05). Hipoalbuminemik hastalar da yara iyileşmesi ve ölüm daha fazla idi.Sonuç: Acil abdominal cerrahi geçirecek yaşlı olgularda hipoalbuminemi mortalite ve morbiditeye etki eden önemli bir belirteç olabilir.
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