Yazar "Taskiran, Benguer" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Frequency Of Thyroid Diseases in Type 2 Diabetic Patients
    (Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2009) Taskiran, Benguer; Guldiken, Sibel; Peynirci, Hande; Altun, Betuel Ugur; Tugrul, Armagan
    Objectives: Thyroid diseases and type 2 diabetes mellitus are two abundant diseases in general population. In this study, we evaluated the frequency of thyroid diseases in type 2 diabetic patients. Patients and Methods: The study included 306 type 2 diabetic patients, who were followed up in Trakya University Department of Endocrinology and Metabolism Disorders. All patients had thyroid function tests, antithyroglobulin antibody values, antithyroid peroxidase values, and thyroid imaging (scintigraphy and/or ultrasonography). Results: A total of 38 (12.4%) patients had thyroid diseases with the following distribution: 29 (9.5%) Hashimoto thyroiditis, five (1.7%) multinodular goitre, three (%1) Graves' disease, and one toxic solitary adenoma (0.3%). Conclusion: We found that thyroid diseases in type 2 diabetics were seen as frequent as in general population. We suggest that there is no need to screen type 2 diabetics for thyroid diseases, hypothyroid in particular, that increase the risk for cardiovascular diseases, in addition to the recommended screening of the general population in guidelines.
  • Küçük Resim Yok
    Öğe
    Serum insulin like growth factor-1 (IGF-1) and insulin like growth factor binding protein-3 (IGFBP-3) levels in liver cirrhosis
    (Turkish Soc Gastroenterology, 2007) Colakoglu, Oender; Taskiran, Benguer; Colakoglu, Guel; Kizildag, Servet; Oezcan, Fulya Ari; Uensal, Belkis
    Background/aims: Impaired growth hormone-insulin like growth factor system in hepatic cirrhosis leads to cirrhosis-relaled complications. In this study, we aimed to investigate whether serum levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 are related to the level of hepatic dysfunction, clinical grade, and etiologic factors of the disease in patients with liver cirrhosis. Methods: Forty-two patients with liver cirrhosis who were diagnosed by means of clinical findings, endoscopy, imaging studies, or histapathology were enrolled in the study. An age- and sex-matched control group was comprised of 37 healthy controls with no signs of liver disease by clinical or laboratory findings. The demographic features (age, sex, height, and weight) and serum levels of liver function tests, area, creatinine, sodium, potassium, insulin like growth factor-1, and insulin like growth factor binding protein-3 and hemogram values were recorded for each individual. The patients were grouped according to Child Pugh classification and etiology. Results: Insulin like growth factor-1 and insulin like growth factor binding protein-3 levels were significantly lower in the cirrhotic group in comparison to the control group (p<0.005). A statistically significaut decrease in levels of insulin like growth factor-1 and insulin like growth factor binding protein-3 was correlated with the degree of liver dysfunction, namely, lowest decrease in Child Pugh class A and highest decrease in class C. With respect to etiology, insulin like growth factor-1 levels of alcohol-related liver cirrhosis were significantly lower than those of hepatitis B-related cirrhosis. There was no relation between insulin like growth factor binding protein-3 level and etiology. In the cirrhotic group, insulin like growth factor-1 level was positively correlated with serum albumin and negatively correlated with serum creatinine and sodium levels and spleen size. Likewise, insulin like growth factor binding protein-3 level was positively correlated with serum albumin. There was a negative correlation between insulin like growth factor binding protein-3 level and serum bilirubin and spleen size. Conclusions: Insulin like growth factor-1 and insulin like growth factor binding protein-3 levels are related to the level of clinical impairment and were independent of the etiology. They may serve as novel markers of hepatocellular dysfunction.