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Öğe Acknowledged statistical help and a better use of p-values: a proposal(Clinical & Exper Rheumatology, 2019) Dincses, E.; Guzelant, G.; Hatemi, G.; Sut, N.; Yazici, H.Objective. The p-value is commonly misused. We hypothesised that a close cooperation with a statistician would go along with a more proper use of p-values. We considered a close cooperation present, when a statistician was a coauthor, or a formal statistical help was acknowledged in a study report. Methods. Randomised controlled trials published in 2015-16 in 4 widely read rheumatology journals were searched for a close cooperation with a statistician, the inclusion of effect sizes, confidence intervals, exact rather than relative p-values and the omission of p-values in tables depicting trial entry data. Results. There were only 28/133 (21%) articles in which a formal statistical help was acknowledged (Group I). The rest (Group II) gave no acknowledgement of a close cooperation. Reporting of effect sizes (96% vs. 71%) and exact p-values (88% vs. 69%) were more in Group I (p=0.01, and p=0.08, respectively). Conclusion. While a formal acknowledgement of a close cooperation was notably infrequent at 21%, this went along with improvement in some aspects of p-value reporting. If substantiated by further studies, we propose that a formally acknowledged statistical help should improve p-value reporting. Like all professionals, statisticians would like their name/office to be formally associated with their good work.Öğe Aromatase inhibitors and radiation-induced lung fibrosis(Amer Soc Clinical Oncology, 2008) Bese, N. S.; Altinok, A. Y.; Ozsahin, E. M.; Yildirim, S.; Sut, N.; Altug, T.; Ober, A.[Abstract Not Available]Öğe Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study(Churchill Livingstone, 2016) Altinok, A. Y.; Yildirim, S.; Altug, T.; Sut, N.; Ober, A.; Ozsahin, E. M.; Azria, D.Purpose: In experimental and clinical trials, tamoxifen (TAM) has been shown to increase radiation-induced lung fibrosis (RILF). Furthermore, aromatase inhibitors (AI) have been shown to be superior to TAM in the adjuvant setting and preclinical data suggest that letrozole (LET) sensitizes breast cancer cells to ionizing radiation in other studies. In this experimental study, we evaluated whether AI have any impact on the development of RILF in rats. Materials and methods: 60 female wistar-albino rats were divided into 6 groups: Control (group A), RT alone (group B), RT + TAM (group C), RT + anastrozole (ANA group D), RT + LET (group E), and RT + exemestane (EXE, group F). RT consisted of 30 Gy in 10 fractions to both lungs with an anterior field at 2 cm depth. Equivalent doses for 60 kg adult dose per day of TAM, ANA, LET, and EXE were calculated according to the mean weight of rats and orally administrated with a feeding tube. Percentage of lung with fibrosis was quantified with image analysis of histological sections of the lung. The mean score values were calculated for each group. the significance of the differences among groups were calculated using one way ANOVA test and Tukey HSD post-hoc test. Results: Mean values of fibrosis were 1.7, 5.9, 6.7, 2.5, 2 and 2.2 for groups A, B, C, D, E, and F, respectively (p = 0.000). TAM increased RT-induced lung fibrosis but without statistical significance. Groups treated with RT + AI showed significantly less lung fibrosis than groups treated with RT alone or RT + TAM (p = 0.000). RT + AI groups showed nearly similar RT-induced lung fibrosis than control group. Conclusions: In this study, we found that AI decreased RT-induced lung fibrosis to the control group level suggesting protective effect. (C) 2016 Elsevier Ltd. All rights reserved.Öğe Assessment of compliance to treatment in asthmatic children(Wiley-Blackwell, 2013) Can, C.; Akkelle, E.; Ozdemir, Gokmirza P.; Yazicioglu, M.; Sut, N.[Abstract Not Available]Öğe Changing the traditional p-value significance threshold to .005 does not decrease the number of statistically significant p-values in observational studies more than in randomised controlled trials(Clinical & Exper Rheumatology, 2021) Oztas, M.; Dincer, Z. T.; Sut, N.; Yazici, H.Oztas, Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Medicine, IUC. Cerrahpasa Tip Fakultesi Yerleskesi, Kocamustafapasa Cd. No: 53 Cerrahpasa, 34098 Fatih/Istanbul, Turkey.Öğe Cognitive evaluation with Montreal cognitive assessment (MOCA) test of patients with obstructive sleep apnea syndrome(Wiley-Blackwell, 2016) Gemici, Y. Inalkac; Celik, Y.; Sut, N.; Ozturk, L.[Abstract Not Available]Öğe Comparison between low flow sevoflurane anesthesia and total intravenous anesthesia during intermediate-duration surgery: effects on renal and hepatic toxicity(Lithographia, 2011) Sahin, S. H.; Cinar, S. O.; Paksoy, I; Sut, N.; Oba, S.Background: Renal and hepatic dysfunction or injury might be involved by ether based anesthetic and intravenous anesthetic drug or surgical stress. The purpose of this study is to compare the effect of moderate duration low-flow sevoflurane versus total intravenous anesthesia on renal and hepatic functions. Patients and Methods: Eighty (80) patients between the ages of 25-70 scheduled for elective lumbar disc herniotomy, with an expected operation time of 120-240 min, were enrolled in the study. Anesthesia was induced using remifentanil, propofol and atracurium. Patients were randomly divided into two groups. After intubation, Group S (n=40) received sevoflurane and Group T (n=40) received total intravenous anesthesia with propofol in oxygen and air with a fresh gas flow of 5 L min(-1). Ten minutes after induction the fresh gas flow was decreased to 1L min(-1) in both groups. Serum BUN, creatinine, ALT, AST, LDH and 24 hours excretion of glucose, protein, and creatinine in urine were measured preoperatively and the first three postoperative days. Results: Serum BUN at 48 hours, creatinine at 24, 48. hours, and urine glucose at 24, and 48 hours were significantly higher from the preoperative values in Group S (p<0.05). However, serum BUN and creatinin, urine glucose were within the normal range. There were no significant differences in the renal and hepatic function tests between the groups. Conclusions: These results show that the renal and hepatic effect of moderate duration low-flow sevoflurane and total intravenous anesthesia is similar. Hippokratia 2011; 15 (1): 69-74Öğe Differences in pain and fatigue perception among a group of rheumatoid arthritis patients in the United States and in Turkey who have similar disease activity and functional status(Clinical & Exper Rheumatology, 2010) Celik, S.; Fresko, I.; Sut, N.; Batumlu, N. M.; Yazici, H.; Yazici, Y.Objectives. The concordance of patient reported outcomes in rheumatoid arthritis (RA) among different countries has not been studied in detail. We tried to determine the differences in pain and fatigue perception among a group of RA patients in the US and in Turkey who had similar disease activity and functional score in multidimensional health assessment questionnaire (MDHAQ FN). Methods. One hundred and thirty-seven RA patients from Turkey and 129 from the US were studied. An MDHAQ was obtained and a DAS-28 was calculated for each patient. Pain and fatigue perception was compared between the two groups after adjusting for age, sex, MDHAQ FN and DAS-28. Results. Turkish patients had less pain than their US counterparts when adjusted for MDHAQ FN, DAS-28, age and sex (3.56 (2.24) vs. 4.35 (2.23), p=0.005) whereas there was no difference infaligue between the two groups (3.85 (2.44) vs. 4.25 (2.45), p=0.194). When the patients with a DAS-28 score of above 5.1 and below 2.6 were compared in both groups, Turkish patients had again less pain albeit less in the high disease activity group. Conclusion. This study suggests that Turkish patients have less pain than the US patients when controlled for age, gender and MDHAQFN and DAS-28 scores. This is at odds to the conventional wisdom that pain perception is increased among the non-Western cultures.Öğe Different responses of apoptotic, inflammatory and heat shock protein gene expression to a single bout of high-intensity interval exercise between physically active and inactive men(Canadian Science Publishing, 2021) Vardar, S. A.; Doganlar, Z. B.; Kaya, O.; Tayfur, P.; Sut, N.; Doganlar, O.High mechanical load of muscles may induce muscular apoptosis on the one hand and adaptation to exercise on the other. This study aimed to explore whether changes of circulatory levels of inflammation, apoptosis and heat shock proteins (HSPs) messenger RNA (mRNA) following single bout of high-intensity interval exercise (HIIE) differs between physically active (PA) and inactive (PI) men. Nine PA and 9 PI (peak oxygen consumption: 2.6 +/- 0.4 vs. 2.0 +/- 0.2 L.min(-1)) healthy men (age: 28.7 +/- 6.3 vs. 30.2 +/- 4.5 years and body mass index: 2.6 +/- 2.1 vs. 23.3 +/- 2.8 kg.m(-2)) performed HIIE, comprising 4 repeats of a Wingate test (load: 0.050 kg.kg(-1) body weight). Blood samples were collected before exercise, 5 min after HIIE, and 24 h after HIIE for measuring mRNA of inflammation markers interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), apoptosis markers including Bcl-2, Bax, and HSP27, HSP60, HSP70, HSP90 using quantitative real-time PCR analysis. Post-HIIE IL-6, TNF alpha and HSP60 were higher in the PI than the PA group 5 min after exercise (p = 0.003, effect size (ES) = 1.59; p = 0.007, ES = 1.59 and p = 0.027, ES = 1.10 respectively). HSP70 acutely increased only in the PA group (p = 0.024, ES = 1.20). The increase in Bcl-2 (p = 0.047, ES = 1.08) and Bax (p = 0.024, ES = 1.20) levels were higher in the PI group 5 min after HIIE. The present study indicated that the response of inflammatory, apoptosis and HSP gene expressions to HIIE in blood of healthy male volunteers strongly depends on their level of regular physical activity. Novelty: Blood IL-6 and HSP60 mRNA levels following high intensity exercise may indicate metabolic stress. Increased blood HSP70 mRNA in physically active men may show an alternative apoptosis suppression pathway.Öğe THE EFFECT OF ANTENATAL STEROID ADMINISTRATION TIME ON POSTNATAL BLOOD PRESSURE IN VERY LOW BIRTH WEIGHT INFANTS(Springer, 2013) Yakar, Y. Cinar; Duran, R.; Acunas, B.; Ciftdemir, N. Aladag; Vatansever, U.; Sut, N.[Abstract Not Available]Öğe Effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block in patients undergoing lower abdominal surgery(Australian Soc Anaesthetists, 2011) Sahin, S. H.; Colak, A.; Sezer, A.; Arar, C.; Sevdi, S.; Gunday, I.; Sut, N.The aim of this study was to evaluate the effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block. Ninety patients undergoing lower abdominal surge, were randomised into two groups after an epidural test dose: the epidural group (n=45) received a bolus of 15 nil of 0.5% levobupivacaine whereas the control group (n=45) did not. Anaesthesia was induced and maintained with propofol, fentanyl, vecuronium and nitrous oxide. Neuromuscular block was induced with vecuronium 0.1 mg/kg and monitored with acceleromyographic train-of-four at the adductor pollicis. Patients in each group received neostigmine at 25% recovery of the first twitch of train-of-four during recovery from anaesthesia. The effect of epidural levobupivacaine on the speed of recovery of neuromuscular function was evaluated. The lag time, onset time and time from vecuronium administration until 25% T1 recovery did not differ between the groups. The times of the recovery index (the time from 25% to 75% recovery of T1) and of the DUR 25-train-of-four 90 (time from 25% T1 to train-of-four ratio of 0.9) in the epidural group were significantly longer than those for the control group (5.2 [2.1] vs 3.04 [1.02] minutes and 10.8 [3.3] vs 8.2 [2.3] minutes, P < 0.001). This study shows that epidural levobupivacaine significantly delays the train-of-four recovery from vecuronium-induced block. Although the interaction is small in the clinical setting, anaesthetists should take this interaction into consideration when combining general and epidural anaesthesia during surgery.Öğe The effect of lipoic acid in the prevention of myocardial infarction in diabetic rats(Comenius Univ, 2018) Ozgun, E.; Ozgun, Sayilan G.; Usta, U.; Eskiocak, S.; Sut, N.; Gokmen, Suer S.OBJECTIVES: We aimed to investigate the effect of lipoic acid in the prevention of myocardial infarction in diabetic rats. METHODS: Rats were divided into five groups as control, ISO, LA+ISO, STZ+ISO and STZ+LA+ISO. To induce diabetes, single dose of streptozotocin was injected to STZ+ISO and STZ+LA+ISO groups. Lipoic acid (10 mg/kg/day) was injected for 14 days to LA+ISO and STZ+LA+ISO groups. To induce myocardial infarction, isoproterenol was injected to ISO, LA+ISO, STZ+ISO and STZ+LA+ISO groups on the days 13 and 14 of lipoic acid treatment. Cardiac necrosis and leucocyte infiltration were investigated histopathologically. Serum malondialdehyde levels, paraoxonase and lactonase activities were measured spectrophotometrically. RESULTS: Isoproterenol caused a significant increase in cardiac necrosis, leucocyte infiltration and serum lipid peroxidation whereas a significant decrease in serum paraoxonase and lactonase activities. In myocardial infarcted non-diabetic rats, while lipoic acid caused a significant decrease in cardiac necrosis, leucocyte infiltration and serum lipid peroxidation and a significant increase in serum paraoxonase and lactonase activities, it did not change these histopathologic or biochemical parameters in myocardial infarcted diabetic rats. CONCLUSION: Lipoic acid, at the dose of 10 mg/kg, is effective to prevent myocardial infarction in non-diabetic rats but it is insufficient in diabetic rats.Öğe Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, 2019) Ozgun, E.; Ozgun, G. S.; Gokmen, S. S.; Eskiocak, S.; Sut, N.; Akinci, M.; Goncu, E.The aim of the present study was to investigate the effect of streptozotocin-induced diabetes mellitus and lipoic acid treatment on serum paraoxonase-1 and paraoxonase-3 protein levels and paraoxonase, arylesterase and lactonase activities. 36 rats were equally and randomly divided into 4 groups as control, lipoic acid, diabetes and diabetes + lipoic acid. To induce diabetes, a single dose of streptozotocin (40 mg/kg) was injected intraperitoneally to diabetes and diabetes + lipoic acid groups. Lipoic acid (10 mg/kg/day) was injected intraperitoneally for 14 days to lipoic acid and diabetes + lipoic acid groups. Serum PON1 and PON3 protein levels were measured bywestern blotting. Serum paraoxonase, arylesterase and lactonase activities were determined by the measuring initial rate of substrate (paraoxon, phenylacetate and dihydrocoumarin) hydrolysis. Streptozotocin-induced diabetes mellitus caused a significant decrease whereas lipoic acid treatment caused a significant increase in serum PON1 and PON3 protein levels and paraoxonase, arylesterase and lactonase activities. The increase percent of serum PON3 protein was higher than that of serum PON1 protein and the increase percent of serum lactonase activity was higher than that of serum paraoxonase and arylesterase activities in diabetes + lipoic acid group. We can report that, like PON1 protein, PON3 protein and actually its lactonase activity may also have a role as an antioxidant in diabetes mellitus and lipoic acid treatment may be useful for the prevention of the atherosclerotic complications of diabetes by increasing serum PON1 and PON3 protein levels and serum enzyme activities.Öğe The effects of concurrent or sequential administration of trastuzumab on radiation-induced pulmonary fibrosis in rats(Amer Soc Clinical Oncology, 2008) Umay, C.; Bese, N. S.; Serdengecti, S.; Kepil, N.; Karaca, C.; Sut, N.; Altug, T.[Abstract Not Available]Öğe THE EFFECTS OF NOISE REDUCTION BY EARMUFFS ON THE PHYSIOLOGIC AND BEHAVIORAL RESPONSES IN VERY LOW BIRTHWEIGHT PRETERM INFANTS(Springer, 2013) Duran, R.; Ciftdemir, N. Aladag; Vatansever, U.; Berberoglu, U.; Durankus, F.; Sut, N.; Acunas, B.[Abstract Not Available]Öğe Effects of propofol and dexmedetomidine on indocyanine green elimination assessed with LIMON to patients with early septic shock: A pilot study(W B Saunders Co-Elsevier Inc, 2009) Memis, Dilek; Kargi, M.; Sut, N.Background: We aimed to select the sedative drug with the least impact on hepatic blood flow in sedation-administered patients. In our study, we aimed to establish whether deximedetomidine and propofol affect liver function during early septic shock. The hepatic blood flow is evaluated by the transcutaneous assessment of indocyanine green plasma disappearance rate (ICG-PDR) in critically ill patients. Methods: Forty early septic shock patients were included in the study and administered either the loading dose infusion of propofol (n = 20, group P) of 1 mg/kg over 15 minutes followed by a maintenance dose of I to 3 mg/kg per hour (n = 20, group P), or a loading dose of dexmedetomidine 1 mu g/kg over 10 minutes followed by a maintenance of 0.2 to 2.5 mu g/kg per hour (n = 20, group D) (24-hour infusion). Indocyanine green (ICG) elimination tests were conducted concurrently using the noninvasive liver function monitoring system (LiMON; Pulsion Medical Systems, Munich, Germany). A dose of 0.3 mg/kg of ICG was given through a cubital fossa vein as a bolus and immediately flushed with 10 mL of normal saline. We Calculated ICG-PDR. Indocyanine green plasma disappearance rate measurements were obtained at baseline (before start of the propofol or dexmedetomidine infusion) and were repeated at the 24th hour. Biochemical and hemodynamic parameters and ICG-PDR were recorded before start of the study and at 24th hour. Results: Biochemical and hemodynamic parameters did not differ significantly between the groups (P<.05). Baseline ICG-PDR levels of group P compared to group D were 24.7 +/- 14.4 vs 21.2 +/- 10.7, respectively, and after the study, ICG-PDR levels (26.5 +/- 13.7 vs 23.7 +/- 12.4) did not differ in groups (P > .05). When we examined ICG-PDR changes between groups before and after administration, there was no significant difference (P > .05). Conclusion: In our study, we found that neither propofol nor dexmedetomidine infusion affected hepatic blood flow. (C) 2009 Elsevier Inc. All rights reserved.Öğe The effects of relaxin on myoglobinuric acute kidney injury in rats(Wiley, 2017) Tarhan, A. Ilhan; Aydogdu, N.; Tastekin, E.; Sut, N.[Abstract Not Available]Öğe Effects Of Respiratory Function, Life Quality, Anxiety And Depression On Exacerbation Count In Cases With Chronic Obstructive Pulmonary Disease(Amer Thoracic Soc, 2017) Cevirme, L.; Altiay, G.; Sut, N.; Caliyurt, O.[Abstract Not Available]Öğe The Effects of Voluntary Physical Activity in Female Rats Fed with Fructose Rich Diet(Wiley, 2017) Tayfur, P.; Gokce, K.; Yilmaz, S.; Barutcu, O.; Ozgur, E. O.; Sut, N.; Vardar, S. A.[Abstract Not Available]Öğe Frequent oral ulceration during early disease may predict a severe disease course in males with Behcet's syndrome(Clinical & Exper Rheumatology, 2012) Hamuryudan, V.; Hatemi, G.; Sut, N.; Ugurlu, S.; Yurdakul, S.; Yazici, H.Objective. The numbers and recurrence rates of mucocutaneous manifestations can be highly variable among patients with Behcet's syndrome (BS) but it is not known whether these differences influence the disease course at the long-term. Methods. We evaluated the outcome of 30 patients that made up the placebo arm of a 6 months controlled trial of thalidomide and looked at the relation between the frequencies of mucocutaneous manifestations during the trial and the development of major organ involvement necessitating immunosuppressives during the post-trial period. Results. Fifteen (50%) patients had received immunosuppresives for major organ involvement during the post-trial period. Patients receiving immunosuppressive treatment were significantly younger at the onset of BS compared to those who did not (24.5 +/- 5 vs. 29.7 +/- 3.8 SD years; p=0.003). The mean number of oral ulcers recorded throughout the trial was significantly higher among patients using immunosuppressives compared to those who did not (2.09 +/- 0.96 vs. 1.43 +/- 0.8; p=0.029). This significance disappeared when adjusted for age of onset of BS (p=0.16). ROC curve analysis showed that having 10 or more ulcers during 6 months has a sensitivity of 86.7% and a specificity of 53% for the subsequent necessity of immunosuppressive use. The same association was not true for genital ulcers, follicular lesions and erythema nodosum. Conclusion. These findings on a limited number of patients suggest that frequent occurrence of oral ulceration during the initial years of the disease may predict the development of major organ involvement in men with BS.
