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Öğe Assessment of relative risk measurement comparing with odds ratio, attributable risk and number needed to treat(Ekin Tibbi Yayincilik Ltd Sti-Ekin Medical Publ, 2007) Suet, Necdet; Senocak, MustafaObjectives: It was aimed to clarify the theoretical aspects of relative risk (RR) and other risk measurements (odds ratio OR, attributable risk AR and number needed to treat NNT), to examine the associations between RR and others, to refer the limitations of RR in medical decision making and to put forward some solution suggestions. Study Design: All possible RR, OR, AR, NNT values and their confidence intervals were calculated in a sample of 200 subjects. In addition, an example practice was performed based on real clinical data. Results: The value of RR was the same in different clinical conditions. The change in absolute risk measurements such as AR and NNT was parallel with clinical change rate. Conclusion: Interpretation of RR causes problem since it can take the same value in different clinical conditions. Therefore, in addition to RR, considering the AR measurement which is parallel with clinical change rate, may be useful while interpreting the RR values.Öğe Assessment of the performances of multilayer perceptron neural networks in comparison with recurrent neural networks and two statistical methods for diagnosing coronary artery disease(Wiley, 2007) Suet, Necdet; Senocak, MustafaWe aimed to examine the diagnostic performances of multilayer perceptron neural networks (MLPNNs) for predicting coronary artery disease and to compare them with different types of artificial neural network methods, namely recurrent neural networks (RNNs) and two statistical methods (quadratic discriminant analysis (QDA) and logistic regression (LR)). MLPNNs were trained with backpropagation, quick propagation, delta-bar-delta and extended delta-bar-delta algorithms as classifiers; the RNN was trained with the Levenberg-Marquardt algorithm; LR and QDA were used for predicting coronary artery disease. Coronary artery disease was classified with accuracy rates varying from 79.9% to 83.9% by MLPNNs. Even though MLPNNs achieved higher accuracy rates than the statistical methods, LR (73.2%) and QDA (58.4%), their performances were lower compared to the RNN (84.7%). Among the four different types of training algorithms that trained MLPNNs, quick propagation achieved the highest accuracy rate; however, it was lower than the RNN trained with the Levenberg-Marquardt algorithm. RNNs, which demonstrated 84.7% accuracy and 86.5% positive predictive rates, may be a helpful tool in medical decision making for diagnosis of coronary artery disease.Öğe The association of triple-marker test results with adverse pregnancy outcomes in low-risk pregnancies with healthy newborns(Springer Heidelberg, 2008) Sayam, N. Cenk; Canda, M. Tunc; Ahmet, Newze; Arda, Sezer; Suet, Necdet; Varol, Fuesun G.Objective This study was designed to investigate the relationship between the second trimester maternal serum markers and adverse pregnancy outcomes in healthy newborns. Materials and methods A total of 749 women who delivered in our institution with complete follow up and second-trimester triple marker test data available were included in the study. Women with multiple pregnancies, chronic diseases, diabetes mellitus, obesity, smokers and infants with chromosomal and congenital abnormalities were excluded. Maternal serum alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG) and unconjugated estriol (uE(3)) values were investigated in our cohort who developed preeclampsia (n = 28), gestational diabetes (GM) (n = 69), preterm labor-birth (n = 100), oligohydramnios n = 37) and macrosomia (n = 59) by using receiver operating characteristic (ROC) curve analysis, with chi-square and Pearson's correlation tests. Results Women with uE(3) <= 1.26 MoM (P = 0.001, AUC = 0.666), HCG > 1.04 MoM (P = 0.032, AUC = 0.599) or AFP <= 0.69 MoM (P = 0.049, AUC = 0.600) values significantly developed oligohydramnios. Also, macrosomic infants were observed in women who had HCG values > 0.86 MoM (P = 0.047, AUC = 0.578). Patients with HCG > 1.04 MoM (P = 0.04, AUC = 0.565) and uE(3) <= 0.88 MoM (P = 0.049, AUC = 0.571) developed GDM. HCG levels, 2.5 or, 3 MoM were significantly associated with the development of oligohydramnios [P = 0.005; OR = 4 (95% CI: 1.7-9.7)], [P = 0.008; OR = 4.9 (95% CI: 1.7-13.7)], respectively. When women with adverse (n = 237) and normal (n = 512) outcomes were compared there were significant differences in maternal serum AFP (1.40 +/- 0.84 vs. 1.23 +/- 0.75 MoM, P = 0.006) and uE(3) values (1.38 +/- 1.42 vs. 1.45 +/- 0.98 MoM, P = 0.001). Conclusions Serum estriol, AFP or HCG values in triple test results may be associated with development of oligohydramnios, gestational diabetes and macrosomia in women with healthy and normal appearing fetuses.Öğe Comparison of temporal artery, mid-forehead skin and axillary temperature recordings in preterm infants <1500 g of birthweight*(Wiley, 2009) Duran, Ridvan; Vatansever, Uelfet; Acunas, Betuel; Suet, NecdetAim: Preterm infants are prone to temperature maintenance problems due to immature thermoregulatory mechanism and relatively large body surface area. The objective of the present study was to evaluate the performance of a new non-invasive infrared thermometer applied to the mid-forehead and temporal artery in comparison with axillary temperature recordings by mercury-in-glass thermometer, and to determine the discomfort caused by these procedures in preterm infants on incubator care. Methods: The present comparative prospective study was composed of 34 preterm infants < 1500 g of birthweight nursed in an incubator. Temperature recording from mid-forehead, temporal artery and axilla were recorded six times a day for 7 days since the end of the first week of life. For pain assessment, the premature infant pain profile (PIPP) was used. Results: The mean mid-forehead, temporal artery and axillary temperatures were 36.72 +/- 0.08, 36.81 +/- 0.09 and 36.71 +/- 0.07 degrees C, respectively. No statistically significant difference was noted between the means of mid-forehead and axillary temperatures. The mean temporal artery temperature was statistically higher than the means of the mid-forehead and axillary temperatures. The PIPP scores of the mid-forehead, temporal artery and axillary temperature measurements were 5.07 +/- 0.36 degrees C, 5.18 +/- 0.43 degrees C and 7.59 +/- 0.84 degrees C, respectively. The mean PIPP score of axillary temperature measurements was statistically higher than the means of mid-forehead and temporal artery measurements. Conclusions: The infrared skin thermometer applied to the mid-forehead is a useful and valid device for easy and less painful measurement of skin temperature in preterm infants < 1500 g of birthweight.