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Öğe Association analysis between A163G and T245G gene polymorphisms of osteoprotegerin and bone mineral density in Turkish postmenopausal women(Wiley, 2017) Palabiyik, O.; Ozdemir, F.; Tokuc, B.; Sipahi, T.; Kabayel, D. Demirbag[Abstract Not Available]Öğe ASSOCIATION OF ANGIOTENSINOGEN T174M AND M235T GENE VARIANTS WITH DEVELOPMENT OF HYPERTENSION IN TURKISH SUBJECTS OF TRAKYA REGION(Taylor & Francis Ltd, 2008) Basak, A. Ay; Sipahi, T.; Ustundag, S.; Ozgen, Z.; Budak, M.; Sen, S.; Sener, S.Genetic determinations of human essential (primary) hypertension are discussed reviewing the candidate genes. Angiotensinogen (AGT) gene, coding the precursor of potent vasoactive hormone angiotensin II, in renin- angiotensin-system (RAS) has been reported to be associated with the onset of hypertension. The aim of this study was to investigate the role of variation in the 174 and 235 sites in exon 2 in AGT gene in the developing of primary hypertension in Turkish subjects from Trakya region. Our study involved 136 subjects, 84 hypertensive and 52 gender and age matched controls. T174M and M235T polymorphisms of the AGT gene were investigated using allele specific polymerase chain reaction (PCR) assay and restriction fragment length polymorphism (RFLP). The frequency of genotypes of the variant T174M in the patients with primary hypertension was TT=%73.8, TM=%26.2, and MM=%0.0, that were not different from the controls TT=%73.1, TM=%26.2, and MM=%1.9. And for M235T; the genotype frequencies in patients with primary hypertension were MM=%19.0 MT=%54.8, and TT=%26.2, which were again not significantly different from that of the controls MM=%26.9 MT=%46.2 and TT=%26.9. In conclusion this study, shows that T174M and M235T variants of the AGT gene were not associated with primary hypertension in Turkish subjects from Trakya region.Öğe Association of eNOS Glu298Asp gene polymorphism with ischemic stroke in Turkish patients(Wiley-Blackwell, 2008) Guldiken, B.; Sipahi, T.; Guldiken, S.; Ustundag, S.; Turgut, N.; Budak, M.; Ozkan, H.[Abstract Not Available]Öğe The CALCA-624 (T/C) gene polymorphism according to homocysteine levels in ischemic stroke subgroups(Springer, 2015) Alkanli, N.; Ay, A.; Alkanli, S. S.; Sipahi, T.; Guldiken, B.; Celebi, C.; Atilgan, E.[Abstract Not Available]Öğe CYCLIN D1 (A870G) GENE POLYMORPHISM IN LUNG CANCER(Elsevier Ireland Ltd, 2011) Cakina, S.; Gulyasar, T.; Sipahi, T.; Ozen, A.; Kocak, Z.[Abstract Not Available]Öğe The effect of gender differences on radiation induced acute lung toxicity by using XRCC1, XRCC3 and HHR2L gene panel(Elsevier Ireland Ltd, 2015) Ozen, A.; Cakina, S.; Turkkan, G.; Cosar, R.; Sipahi, T.; Kocak, Z.; Uzal, C.[Abstract Not Available]Öğe Effect of high protein diet and exercise on cardiac Aquaporin 7 expression(Wiley-Blackwell, 2014) Palabiyik, O.; Karaca, A.; Vardar, S. A.; Tastekin, E.; Yamasan, B. E.; Tokuc, B.; Sipahi, T.[Abstract Not Available]Öğe Endothelial nitric oxide synthase intron 4a/b polymorphism in coronary artery disease in Thrace region of Turkey(Taylor & Francis Ltd, 2014) Sivri, N.; Unlu, A.; Palabiyik, O.; Budak, M.; Kacmaz, Y.; Yalta, K.; Sipahi, T.Coronary artery disease (CAD) is one of the frequent cardiovascular mortality causes in the world. Common risk factors explain only about half the risk of CAD. The healthy familial predisposition to CAD, combined with advances in genetic analysis, has led to a number of studies in recent years making an effort to identify the genetic factors that influence the risk. The approach taken by most studies was to examine the association of naturally occurring genetic polymorphisms in candidate genes with risk of or severity of CAD. Endothelial nitric oxide synthase (eNOS) is important for vascular and tissue protection and is found in endothelial cells that encompass the entire vasculature, including the vessels in the heart. Nitric oxide (NO) is produced in a catabolic reaction in the endothelial cells, neurons, glia and macrophages by nitric oxide synthase (NOS) isoenzymes. eNOS is a subgroup of this family of enzymes that catalyses the production of nitric oxide (NO) from L-arginine and oxygen, which leads to vascular relaxation by activating the guanylate cyclase. This finally induces smooth muscle relaxation. The aim of this study was to investigate the allelic frequency and the genotypic distribution of the variable number of tandem repeat 27 (27 VNTR) gene polymorphism in intron 4 of the eNOS (eNOS 4a/b) gene in Thrace region, to compare CAD patients with appropriate healthy controls and to correlate the genetic findings with CAD subtypes. The study group included 281 (153 subjects with CAD and 128 controls) patients. The eNOS polymorphism was identified with a polymerase chain reaction. Genotypes were defined as aa, ab and bb according to the presence of a and b alleles. In this case-control study, we found that there was sensible correlation between eNOS gene intron 4a/b VNTR polymorphism and the risk of CAD in Thrace region of Turkey. However, there was no major difference for the genotype distribution and the allelic frequency among the CAD subtypes. Further studies on the interaction of such genes are needed to clarify the association between eNOS 4a/b polymorphism and CAD patients.Öğe EVALUATION OF BRCA 1-2 GENE MUTATIONS IN PATIENTS WITH TRIPLE NEGATIVE AND ER(-), PR(-), HER-2(+) BREAST CANCER(Elsevier Ireland Ltd, 2011) Uzal, M. C.; Sener, S.; Ozen, A.; Cakina, S.; Sipahi, T.; Cosar, R.; Gulyasar, T.[Abstract Not Available]Öğe GNB3 gene c.825C>T polymorphism and performance parameters in professional basketball players(Akademiai Kiado Zrt, 2014) Gulyasar, T.; Ozturk, L.; Sipahi, T.; Bayraktar, B.; Metin, G.; Yucesir, I.; Sut, N.This study has been conducted to determine whether mean values of peak oxygen consumption (VO2peak), anaerobic test parameters and knee isokinetic test measurements are different among guanine nucleotide-binding protein, beta-3 (GNB3) genotype groups in a group of basketball players. Methods: Seventy-two healthy male (mean age, 22.9 +/- 5.3 years) basketball players from the first division of national league participated. We studied GNB3 gene c. 825C>T (rs5443) polymorphism, then divided the subjects into three groups as CC (n = 21), CT (n = 35), and TT (n = 16). Mean VO2peak, Wingate anaerobic test results, and isokinetic knee muscle strength measurements were compared among the genotype groups. Results: Mean VO2peak (60.1 +/- 3.9; 56.7 +/- 3.6; and 57.8 +/- 3.3, respectively, p < 0.01), mean anaerobic minimum power (5.1 +/- 0.4; 5.3 +/- 0.5; and 4.4 +/- 0.5 W/kg, respectively, p < 0.001), mean anaerobic power drop (57.0 +/- 6.2; 54.2 +/- 6.9; and 62.9 +/- 5.3%, respectively, p < 0.001) were significantly different among the study groups, CC, CT, and TT. Individuals with TT genotype exerted lower performance in terms of isokinetic knee muscle strength. Conclusion: The presence of 825T-allele may impair athletic performance and may serve as a genetic marker of low capacity for athletic performance in male basketball players.Öğe Identifying the Interaction Site of Poly ADP-ribose Polymerase-4 with NAD by Using Molecular Dynami(Springer, 2017) Unlu, A.; Dinc, B.; Budak, M.; Sipahi, T.; Bektas, M.; Nurten, R.[Abstract Not Available]Öğe Investigation of GSTM1 polymorphism genotypes and serum trace elements in colorectal cancer(Springer, 2015) Ay, A.; Alkanli, N.; Gulyasar, T.; Sipahi, T.; Cicin, I.[Abstract Not Available]Öğe LACK OF EVIDENCE FOR CONTRIBUTION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE INTRON 4 VNTR GENE POLYMORPHISMS TO DEVELOPMENT OF ISCHEMIC STROKE IN TURKISH SUBJECTS(Taylor & Francis Ltd, 2009) Sipahi, T.; Basak, A. A.; Ozgen, Z.; Aksoy, A.; Omurlu, I. K.; Palabiyik, O.; Cakina, S.The gene polymorphisms of the vasodilator endothelial nitric oxide synthase (eNOS) are considered as important candidate genetic risk factors for vascular diseases. The present study aimed to assess the genotypic distribution and the allelic frequency of the four repeals (a allele), and the five repeats (b allele) of 27 bp in intron 4 of eNOS gene (eNOS VNTR 4 a/b) in Turkish ischemic stroke patients compared to controls. The study population included 197 (102 males, 95 females) patients with ischemic stroke which were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) as large vessel disease or small vessel disease patients, and 144 (36 males, 108 females) controls. The eNOS VNTR 4 a/b gene polymorphisms were identified with a polymerase chain reaction. Genotypes were defined as aa; 394 bp fragment, ab; 394 and 421 bp fragments, and bb; 421 bp fragment according to the presence of the a and b alleles. In this stroke-control study, we did not find any significant difference in either the genotypic distribution or allelic frequency of eNOS VNTR 4 a/b gene polymorphism between the ischemic stroke patients and the controls (p>0.05). We also did not find any significant difference in either the genotypic distribution or allelic frequency according to gender (p>0.05). In addition, there was also no significant difference for the genotype distribution and the allelic frequency among the stroke subtypes (p>0.05), or according to gender in stroke subgroups (p>0.05). The results suggested the lack of an association between the VNTR 4 a/b gene polymorphisms of eNOS gene and ischemic stroke or between the VNTR 4 a/b gene polymorphisms of eNOS gene and subtypes of ischemic stroke in Turkish population in the Trakya region.Öğe Polymorphisms of the angiotensin-converting enzyme and angiotensin II receptor type 1 genes and association with stroke in Turkish subjects of the Trakya region(Wiley-Blackwell, 2008) Sipahi, T.; Guldiken, B.; Budak, M.; Guldiken, S.; Ustundag, S.; Turgut, N.; Ozkan, H.[Abstract Not Available]
