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    The effects of dietary ascorbic acid supplementation on collagen and amino acid concentrations in Japanese quails exposed to heat stress
    (Tubitak Scientific & Technological Research Council Turkey, 2010) Seyrek, Kamil; Erbas, Hakan; Serter, Mukadder; Yenisey, Cigdem; Kiral, Funda; Bardakcioglu, Huesnue Erbay
    A considerable body of data exists regarding the role of vitamin C in mammalian physiology; however, there are no data about the effects of dietary ascorbic acid supplementation on collagen concentrations and amino acid levels in animals exposed to heat stress. The present study investigated the effects of supplementary ascorbic acid intake on collagen concentrations in the brain and heart tissue in Japanese quails. In addition, glycine, glutamine, histidine, asparagine, and serine contents in the livers of the same animals were measured. Japanese quails were allocated into 4 groups, each of which was exposed to heat stress (34.8 +/- 1.25 degrees C) for 75 days. Control animals were fed a basal diet, while animals in the experimental groups were fed a basal diet supplemented with 150, 250, or 500 mg of L-ascorbic acid kg(-1) of diet. Compared to the control group, mean collagen concentration in brain tissue significantly (P < 0.05) increased only in Japanese quails given 250 mg of L-ascorbic kg(-1) of diet. On the other hand, heart tissue collagen content in the quails fed vitamin C did not significantly increase; in fact, the collagen content in the group fed 500 mg of L-ascorbic acid kg(-1) of diet significantly decreased (P < 0.01). Amino acid content in the liver significantly increased in the group fed 150 mg of L-ascorbic acid kg(-1) of diet (P < 0.01 for serine and P < 0.001 for the others). In conclusion, vitamin C had profound effects on collagen synthesis and amino acid metabolism in Japanese quails subjected to heat stress. Results of the present study also indicate that addition of high-dose dietary vitamin C-higher than 250 mg kg(-1) of diet-may have detrimental effects in quails exposed to heat stress.
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    PREVENTIVE EFFECTS OF ALPHA-LIPOIC ACID ON DIABETIC NEPHROPATHY IN A RAT MODEL
    (Carbone Editore, 2014) Ayhan, Medina; Guney, Engin; Atile, Neslihan Soysal; Serter, Mukadder; Meteoglu, Ibrahim
    Objective: Diabetic nephropathy is the major cause of chronic renal failure, and oxidative stress has an important role in its etiology. Aim of this study is to investigate the effects of the antioxidant alpha-lipoic acid (ALA) treatment on proteinuria, antioxidant enzyme and inflammatory cytokine levels in the renal tissue and renal histopathology in diabetes. Design: Thirty male Wistar rats were divided into three groups: normal control group (n=10), diabetic control group (n=10), and ALA treated diabetic group (n=10). Diabetes was induced by a single ultra venouse injection of streptozotocin. Rats which completed 4 weeks of the study period were sacrificed after 24 hour urine collection for albuminuria detection. Histopathological examination was performed. Antioxidant enzyme and inflammatory marker levels in renal tissue were measured. Results: The 24 hour urinary albumin levels were significantly reduced in the ALA-treated diabetic group compared with the diabetic control group. In ALA administered rats, histopathological findings such as tubular dilation, tubular epithelium necrosis, glomerular focal necrosis, and interstitial inflammation were observed at a lesser extent than the diabetic control group. Any difference was not detected between the diabetic control group, and the ALA group with respect to the levels of GSH, GSH-r, MDA, TNF-alpha and IL-6. Conclusion: ALA administration led to regression of histopathologic and morphologic lesions in extracted rat kidney. Also positive effect of ALA on albuminuria was detected. However, no positive effect of ALA was found for antioxidant parameters at the tissue level.