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Öğe 99mTc-dextran scintigraphy to detect disease activity in patients with rheumatoid arthritis(Lippincott Williams & Wilkins, 2004) Kaya, M; Tuna, H; Firat, MF; Tuna, F; Seren, G; Yigitbasi, ÖNAim To test the applicability of Tc-99m-dextran joint scintigraphy in the assessment of disease activity in patients with rheumatoid arthritis (RA), and to compare it with the clinical disease activity scores and laboratory parameters. Methods Twenty-seven patients with RA were investigated using Tc-99m-dextran joint scintigraphy. The images were evaluated semi-quantitatively and the regional uptakes of the radiopharmaceutical were calculated for the knee, wrist and ankle joints. The clinical and laboratory parameters were collected and fully analysed. An articular Ritchie index (a tender joint score), the number of swollen joints (Sw), the number of tender joints, the morning stiffness h, the total Ritchie articular index (R), the visual analogue scale (VAS) and the Disease Activity Score (DAS) were determined for all patients. Results Compared with controls, patients with RA had significantly higher regional Tc-99m-dextran uptake in the knee, wrist and ankle joints (P=0.001). The regional 99mTc-dextran uptake showed no correlation with the patient's age, gender, duration of disease, number of swollen joints (Sw), number of tender joints, morning stiffness (h), VAS, total Ritchie articular index and DAS, or any laboratory parameters. There was a significant correlation between the regional Tc-99m-dextran uptake for individual joints and the articular Ritchie index of the right and left wrist (r=0.42, P=0.03; r=0.45, P=0.02), right and left knee (r=0.66, P<0.0001; r=0.80, P<0.0001) and right and left ankle (r=0.47, P=0.014; r=0.76, P<0.0001), respectively. Conclusions This study demonstrates that 99mTc-dextran scintigraphy is a sensitive method to detect active joint inflammation and could be useful in the management of patients with RA. (C) 2004 Lippincott Williams Wilkins.Öğe A comparative study of human seminal plasma and blood serum trace elements in fertile and infertile men(Taylor & Francis Inc, 2002) Seren, G; Kaplan, M; Ibar, HConcentration of lead, cadmium, copper and zinc in seminal plasma and blood serum collected from fertile and infertile men (30 + 30) were determined by atomic absorption spectrometry (AAS). The mean blood and seminal plasma concentrations of lead, cadmium, copper and zinc-were within the normal values. The blood concentration of lead, cadmium, copper and zinc were 64.15 +/- 21.4 mug/L, 0.16 +/- 0.08 mug/L, 106.9 +/- 83.5 mug/L, 212.9 +/- 138.6 mug/L in fertile men and 65.08 +/- 21.6 mug/L, 0.30 +/- 0.15 mug/L, 203.3 +/- 129.6 mug/L and 75.5 +/- 13.3 mug/L in infertile men, respectively. The seminal plasma concentrations of these metals were 62.86 +/- 26.1 mug/L, 0.67 +/- 0.09 mug/L, 105.6 +/- 94.8 mug/L and 130.6 +/- 107.4 mug/L in fertile men and 63.14 +/- 33.4 mug/L, 0.74 +/- 0.3 mu/L, 177.7 +/- 165.3 mug/L and 83.02 +/- 28.5 mug/L in infertile men, respectively. Blank values were very low and detection limits (3sigma) were found for each analysis.Öğe Concentration of cadmium, copper and zinc using water soluble polyacrylic acid polymer(Pergamon-Elsevier Science Ltd, 2000) Bakircioglu, Y; Seren, G; Akman, SIn this study, a simple method was developed to use water soluble polymer, polyacrylic acid, for the separation and pre-concentration of trace Cd, Cu and Zn prior to their analysis by flame atomic absorption spectrometry. For this purpose, the sample and poly-acrylic acid were mixed and the metal-bound polymer was precipitated by the addition of acetone. The precipitate was separated and dissolved in a minimum amount of water and aspirated into a flame AAS. The method was compared with traditional water insoluble sorbents in all aspects. The technique described is fast, simple, precise and inexpensive. Blank values were low and recoveries were 96.5% for Cd, 99.7% for Cu and 98.0% for Zn. Detection limits (3 sigma) were 1.8 mu g 1(-1) for Cd, 2.5 mu g 1(-1) for Cu, and 2.2 mu g 1(-1) for Zn. (C) 2000 Elsevier Science B.V. All rights reserved.Öğe Determination of cadmium, copper, and zinc by flame atomic absorption spectrometry after preconcentration using a DETA (diethylenetriamine) polymer(Marcel Dekker Inc, 2001) Bakircioglu, Y; Seren, G; Akman, SAn atomic absorption spectrometric method with a preconcentration and separation procedure using a DETA (diethlyenetriamine) polymer is proposed for the determination of Cd, Cu and Zn. The influence various experimental condition on retention and elution efficiencies of the analyte were investigated by applying batch and column techniques. All investigated elements were quantitatively retained at pH 3, then were completely recovered by means of nitric acid. The loading capacity of the DETA polymer is 5.2 mg Cu2+/g polymer. A contact time of one minutes is sufficient for quantitative retention and elution which is shorter than for many Other sorbents. In the presence of sodium chloride up to 0.5% the analyte elements were quantitatively Separated and recovered.Öğe Investigation on the preconcentration of trace elements on activated bentonite(Inst Lebensmitteltechnologie Analytische Chemie, 2001) Seren, G; Bakircioglu, Y; Çoban, F; Akman, SIn this study, activated bentonite was used for the separation and preconcentration of cobalt, copper and manganese prior to their determination by flame atomic absorption spectrometry (FAAS). The bentonite used in this study was obtained from west part of Turkey, Enez, Edirne. Optimum conditions for the separation and preconcentration of analyte elements were investigated. Bentonite was further purified by treating the material with 4.0 mol L-1 hydrochloric acid for the removal of contaminants before use. Both batch and column methods were used for the separation of the above metals. In the batch method, the effects of pH and shaking time on retention and elution were investigated. The elements were quantitatively retained by the collector at pH 4 and again quantitatively eluted with of 0.1 mol L-1 EDTA for Cc and Mri and 2.0 mol L-1 HCl for Cu and Mn. Blank values were low and recoveries were 99.2 +/- 2%, 99.6 +/- 1% and 99 +/- 1% for Co, Cu and Mn, respectively, at 95% confidence level. The relative standard deviations for the determinations were found to be 1.0-8.8%. Detection limits (3 sigma) were 1.5 mug L-1 for Co, 0.9 mug L-1 for Cu, and 1.4 mug L-1 for Mn. The maximum loading capacity was found to be 0.22 mg g(-1) bentonite for copper using batch procedure. The method was applied to the analysis of the elements studied in waste water and ground water.
