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Öğe ASSOCIATION OF ANGIOTENSINOGEN T174M AND M235T GENE VARIANTS WITH DEVELOPMENT OF HYPERTENSION IN TURKISH SUBJECTS OF TRAKYA REGION(Taylor & Francis Ltd, 2008) Basak, A. Ay; Sipahi, T.; Ustundag, S.; Ozgen, Z.; Budak, M.; Sen, S.; Sener, S.Genetic determinations of human essential (primary) hypertension are discussed reviewing the candidate genes. Angiotensinogen (AGT) gene, coding the precursor of potent vasoactive hormone angiotensin II, in renin- angiotensin-system (RAS) has been reported to be associated with the onset of hypertension. The aim of this study was to investigate the role of variation in the 174 and 235 sites in exon 2 in AGT gene in the developing of primary hypertension in Turkish subjects from Trakya region. Our study involved 136 subjects, 84 hypertensive and 52 gender and age matched controls. T174M and M235T polymorphisms of the AGT gene were investigated using allele specific polymerase chain reaction (PCR) assay and restriction fragment length polymorphism (RFLP). The frequency of genotypes of the variant T174M in the patients with primary hypertension was TT=%73.8, TM=%26.2, and MM=%0.0, that were not different from the controls TT=%73.1, TM=%26.2, and MM=%1.9. And for M235T; the genotype frequencies in patients with primary hypertension were MM=%19.0 MT=%54.8, and TT=%26.2, which were again not significantly different from that of the controls MM=%26.9 MT=%46.2 and TT=%26.9. In conclusion this study, shows that T174M and M235T variants of the AGT gene were not associated with primary hypertension in Turkish subjects from Trakya region.Öğe The effects of Enalapril and Irbesartan in experimental diabetic nephropathy(Diagnosis Press Ltd, 2007) Yalcin, O.; Ustundag, S.; Sen, S.; Usta, U.; Huseyinova, G.; Puyan, F. Oz; Kutlu, K.In our study we investigated the effects of angiotensin converting enzyme inhibitor and Angiotensin T, receptor blocker at low-doses which do not affect blood pressure and renal hemodynamia on the experimental diabetic nephropathy. Diabetes mellitus was induced by 50 mg/kg streptozotocin on Sprague-Dawley rats. Except for the patient control group, 2.5 mg/kg Enalapril (an angiotensin converting enzyme inhibitor) and 5 mg/kg Irbesartan (an Angiotensin T, receptor blocker) were given everyday via drinking water during six weeks period. After 24-hour urine collection, blood was withdrawn by cardiac puncture, and rats were sacrificed. Renal functions, histopathologic and electron microscopic alterations in renal tissues, and relative percent deposition of type IV Collagen were investigated. Diabetic nephropathy was determined with the increase of plasma glucose, HbA(9)C (P< 0. 000), urea, creatinin (P<0.005) and urinary protein, albumin, glucose (P<0. 000) inpatient control and Enalapril and Irbesartan treatment groups when compared to the healthy control group. Mesangiocellular proliferation, tubular basement membrane thickness, percentage of glomerular collagen accumulation reduced in treatment groups and glucose in urine in Enalapril group declined. Our findings suggest that renal protective effects of Enalapril and Irbesartan in the development of diabetic nephropathy were comparable.Öğe Quantitative analysis of salivary gland scintigraphy in tobacco smoker(Springer, 2005) Sen, S.; Durmus-Altun, G.; Bedel, D.[Abstract Not Available]
