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Öğe Can Increases in Soft Tissue Thickness Lead to Attenuation Artifacts Causing Apparent Cardiopulmonary Perfusion Defects Post-RT?(Elsevier Science Inc, 2011) Lawrence, M. V.; Roper, J.; Saynak, M.; Fried, D.; Bateman, T.; Wong, T.; Das, S.[Abstract Not Available]Öğe Chemotherapy and cerebrovascular disease(Zerbinis Medical Publ, 2008) Saynak, M.; Cosar-Alas, R.; Yurut-Caloglu, V.; Caloglu, M.; Kocak, Z.; Uzal, C.Cerebrovascular disease is common in cancer patients. Some tumors are at high risk for cerebrovascular complications. The development of cerebrovascular disease may be provoked by cancer treatment. No well-planned prospective studies about other causes of thrombosis are available, although various case reports about thrombosis related to chemotherapy have been published. L-asparaginase, cisplatin, 5-fluorouracil (5-FU) and methotrexate are anticancer agents which are reported to relate to stroke. The mechanisms by which antineoplastic agents may lead to stroke include endothelium toxicity and abnormalities of coagulation factors. Also, brain hemorrhages that could result from chemotherapy effects on the hemostatic system were reported. Besides, it is difficult to determine whether stroke is caused by chemotherapy or cancer itself Clinicians deal not only with problems originating from cancer itself but also with the complications resulting from its treatment. Treatment-induced cerebrovascular disorders affect quality of life and survival in cancer patients. For this reason, cancer treatment should be planned by taking into consideration the possibility of cerebrovascular complications.Öğe FDG-PET vs. Histologic Staging of the Mediastinum in Patients With Pathologic N0-1 Non-small Cell Lung Cancer (NSCLC): What Should Be the Gold Standard?(Lippincott Williams & Wilkins, 2010) Xie, L.; Saynak, M.; Chiu, W.; Bailey, J. E.; Fried, D. V.; Veeramachaneni, N. K.; Hubbs, J. L.[Abstract Not Available]Öğe Investigation of differences of sacral and vertebral bone mineral densities before and after radiotherapy in patients with locally advanced rectal cancer(Elsevier, 2019) Hayar, M.; Durankus, N. K.; Altun, G. D.; Kocak, Z.; Uzal, M. C.; Saynak, M.Purpose. - Radiotherapy is a treatment method performed using ionizing radiation on cancer patients either alone or with surgery and/or chemotherapy. Although modern radiotherapy techniques provide a significant advantage in protecting healthy tissues, it is inevitable that normal tissues are also located in the areas targeted by radiations. In this study, we aimed to examine the bone mineral density changes in bone structures commonly included in the irradiated area such as, L5 vertebra, sacrum, and femur heads, in patients who have received pelvic radiotherapy; and the relationship between these changes with radiation dose. Material and methods. - Patients included in the study had been previously diagnosed with rectal cancer, which were operated or not. Preoperative or postoperative pelvic radiotherapy was planned for all patients. In terms of convenience when comparing with future scans, all densitometry and CT scans were performed with the same devices. Fifteen patients were included in the study. In order to determine the dose of radiation each identified area had taken after radiotherapy, the sacrum, L5 vertebra, bilateral femoral heads, and L1 regions were contoured in the CT scans in which treatment planning was done. Sagittal cross-sectional images were taken advantage of while these regions were being contoured. Results. - Bone mineral density was evaluated with CT and dual-energy X-ray absorptiometry before and after the treatment. The regions that have theoretically been exposed to irradiation, such as L5, sacrum, left to right femur were found to have significant difference in terms of bone density. According to CT evaluation, there was a significant decrease in bone intensity of L5, sacrum, left and right femurs. Dual energy X-ray absorptiometry assessment revealed that the whole of the left femoral head, left femur neck and Ward's region were significantly affected by radiotherapy. However, there was no significant difference in the sacrum and L5 vertebra before and after radiotherapy. Conclusion. - More accurate results could be achieved if the same study was conducted on a larger patient population, with a longer follow-up period. When the reduction in bone density is at maximum or a cure is likely in a long-term period, bone mineral density could be determined by measurements performed at regular intervals. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.Öğe Local Failure after Complete Resection of Early-Stage Non-small Cell Lung Cancer: The Potential Role of Postoperative Radiation Therapy(Elsevier Science Inc, 2009) Saynak, M.; Veeramachaneni, N. K.; Hubbs, J. L.; Nam, J.; Marks, L. B.[Abstract Not Available]Öğe PROTECTIVE ROLE OF CARNITINE AGAINST RADIATION-INDUCED KIDNEY DAMAGE IN INFANT RATS: SCINTIGRAPHIC AND HISTOPATHOLOGIC EVALUATION(Elsevier Ireland Ltd, 2011) Rusen, C.; Altun, G. Durmus; Puyan, F. Oz; Saynak, M.; Ibis, K.; Ozen, A.; Bayir-Angin, G.[Abstract Not Available]Öğe The role of postoperative radiotherapy in node negative breast cancer patients with pT3-T4 disease(Elsevier Sci Ltd, 2007) Aksu, G.; Kucucuk, S.; Fayda, M.; Saynak, M.; Baskaya, S.; Saip, P.; Ozturk, N.Aims: To evaluate the role of postmastectomy radiotherapy (PMRT) in patients with pT3-T4N0M0 breast cancer. Methods: 156 patients with T3-T4N0M0 breast cancer were retrospectively analyzed. Results: Locoregional recurrences were seen in 17 of 156 patients with a median time for development of 27 months (5.7-248.7 months). Two of 9 patients who were not treated with post-operative radiation therapy had locoregional recurrence as compared with 16 of 147 patients receiving radiotherapy. In multivariate analysis, presence of locoregional recurrence was the only significant prognostic factor for overall survival (18% vs. 86%, p < 0.001, RR = 9.05). The patients with a median number of dissected lymph nodes >= 10 had a significantly better locoregional disease free survival rate as compared with patients with dissected lymph nodes < 10 (90% vs. 78%, p = 0.04). Chest wall recurrences were clearly higher in patients without chest wall RT since 5 of 49 patients without RT had recurrences in the chest wall region while only 4 of 107 who received chest wall RT had recurrence. However receiving RT to peripherical lymphatic regions had no additional effect on reducing recurrences in these regions (5% vs. 4%). Conclusions: Due to the lack of phase III randomized trials directly addressing the role of postmastectomy radiotherapy in these stages, our series suggest that postmastectomy radiotherapy to the ipsilateral chest wall is recommended for patients with PT3N0 and T4N0 breast cancer. The need for irradiating axillary or supraclavicular region shall be neglected in patients who undergo sufficient axillary sampling. (c) 2006 Elsevier Ltd. All rights reserved.Öğe Sudden death: A case report of hepatocellular carcinoma with tumor thrombus extending into the right atrium(Zerbinis Medical Publ, 2007) Saynak, M.; Ozen, A.; Kocak, Z.; Cosar-Alas, R.; Uzal, C.[Abstract Not Available]
