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Öğe 99mTc sestamibi muscle scintigraphy to assess the response to neuromuscular electrical stimulation of normal quadriceps femoris muscle(Springer-Verlag, 2001) Pekindil, Y; Sankaya, A; Birtane, M; Pekindil, G; Salan, A[Abstract Not Available]Öğe 99mTc-MIBI SPET in non-small cell lung cancer in relationship with Pgp and prognosis(Springer, 2002) Yüksel, M; Çermik, TF; Doganay, L; Karlikaya, C; Çakir, E; Salan, A; Berkarda, SHigher technetium-99m methoxyisobutylisonitrile (MIBI) uptake in non-small cell lung cancer (NSCLC) has been reported to be associated with a positive response to chemotherapy. It has previously been found that in tumour cells, P-glycoprotein (Pgp) expression is of importance for tracer uptake. However, some studies have indicated that Pgp expression does not play an important role in Tc-99m-MIBI uptake in NSCLC; indeed, a negative correlation between 99mTc-MIBI uptake and Pgp expression has been reported. Against the background of conflicting results, our aim was to evaluate the relationship between Tc-99m-MIBI uptake, prognosis and Pgp expression in NSCLC. A total of 37 patients with NSCLC underwent Tc-99m-MIBI single-photon emission tomography (SPET) before chemotherapy. In 19 patients both Pgp and p53 expression, and in two patients only p53 expression (due to the limited biopsy material), were measured with immunohistochemical staining. Tc-99m-MIBI uptake was significantly higher in responders than in non-responders: 3.09+/-1.14 vs 2.24+/-0.88 (P<0.03) and 3.09+/-1.08 vs 2.37+/-1.06 (P<0.05) for the early ratio (ER) and the delayed ratio (DR), respectively. The wash-out rate (WR) of responders was not significantly different from that of non-responders. We found no significant differences in ER, DR and WR among the groups positive or negative for Pgp and p53 status. There was a significant positive correlation between the survival rate and both ER and DR: r=0.49 (P=0.003) and r=0.40 (P=0.018), respectively. Patients with ER and DR values above 3 showed significantly longer survival than those with values below 3: 14.7+/-8.5 months vs 7.3+/-5.1 months (P<0.009) and 13.2+/-8.4 months vs 7.4+/-5.3 months (P<0.04) for ER and DR, respectively. However, interestingly, and in contrast to expectations, patients with a Pgp score of +2 showed significantly longer survival (12.9+/-6.7 months) than those with Pgp scores of +1 (4.4+/-3.0 months) or - (negative) (3.8+/-2.2 months) (P<0.009 and P<0.02, respectively). Our results suggest that in NSCLC, patients with higher Tc-99m-MIBI uptake tend to show a positive response to chemotherapy, and patients with ER and DR values above 3 have a significantly better prognosis. We also found that Pgp expression seems to play only a minor role in Tc-99m-MIBI uptake. Our finding that patients with ER and DR values above 3 have a better prognosis needs to be confirmed in larger series of patient.Öğe 99mTc-sestamibi muscle scintigraphy to assess the response to neuromuscular electrical stimulation of normal quadriceps femoris muscle(Japanese Society Nuclear Medicine, 2001) Pekindil, Y; Sarikaya, A; Birtane, M; Pekindil, G; Salan, AObjectives: Neuromuscular electrical stimulation (NMES) is widely used for improving muscle strength by simultaneous contraction in the prevention of muscle atrophy. Although there exist many clinical methods for evaluating the therapeutic response of muscles, Tc-99m-sestamibi which is a skeletal muscle perfusion and metabolism agent has not previously been used for this purpose. The aim of our work was to ascertain whether Tc-99m-sestamibi muscle scintigraphy is useful in the monitoring of therapeutic response to NMES in healthy women. Methods: The study included 16 women aged between 21 and 45, with a mean age of 32.7 +/- 6.4. Both quadriceps femoris muscles (QFM) of each patient were studied. After randomization to remove the effect of the dominant side, one QFM of each patient was subjected to the NMES procedure for a period of 20 days. NMES was performed with an alternating biphasic rectangular current, from a computed electrical stimulator daily for 23 minutes. After measurement of skinfold thickness over the thigh, pre- and post-NMES girth measurements were assessed in centimeters. Sixty minutes after injections of 555 MBq Tc-99m-sestamibi, static images of the thigh were obtained for 5 minutes. The thigh-to-knee uptake ratio was calculated by semiquantitative analysis and normalized to body surface area (NUR = normalized uptake ratio). Results: The difference between the pre and post NMES NUR values was Significant (1.76 +/- 0.31 versus 2.25 +/- 0.38, p = 0.0000). The percentage (%) increase in NUR values also well correlated with the % increase in thigh girth measurements (r = 0.89, p = 0.0000). Conclusion: These results indicated that Tc-99m-sestamibi muscle scintigraphy as a new tool may be useful in evaluating therapeutic response to NMES.Öğe The bronchoalveolar epithelial permeability in house painters as determined by Tc-99m DTPA aerosol scintigraphy(Springer, 2003) Kaya, M; Salan, A; Tabakoglu, E; Aydogdu, N; Berkarda, SPurpose: Isocyanates are highly reactive chemicals used in a number of industries including paints. Therefore, house painters are known to be at risk for occupational exposure to isocyanates. Our objectives in this study were: (1) to investigate the possible effects of isocyanate exposition on the bronchoalveolar epithelial permeability in house painters by using Tc-99m DTPA radioaerosol lung scintigraphy; (2) to assess whether or not some differences exist between asthmatic and non-asthmatic house painters, and (3) to determine the relationship between Tc-99m DTPA radioaerosol lung scintigraphy and the spirometric measurements, and the work duration of house painters. Materials and Methods: Ten non-smoking house painters (28.8 +/- 8.8 yrs) and ten healthy volunteers underwent Tc-99m DTPA radioaerosol lung scintigraphy. Following inhalation of radiotracer through a nebulizer for 5 minutes, dynamic scintigrams (1 frame/min, up to 10 min) were taken from both lungs. ROI's were drawn over the both lung area, and time-activity curves were obtained, from which the half-time (T-1/2) of Tc-99m DTPA clearance was calculated. Spirometric lung function test was measured in all house painters. Results: Mean T1/2 values (min +/- SD) were 93.74 +/- 32.79 for house painters, and 90.96 +/- 40.02 for control subjects. There was no significant difference in T1/2 values of Tc-99m DTPA clearance between house painters and controls, and between asthmatic and non-asthmatic house painters as well. No correlation was observed between Tin values of Tc-99m DTPA clearance and spirometric measurements. In house painters, there was a positive correlation between T1/2 values of Tc-99m DTPA clearance and work duration (r = 0.73, p = 0.016). Conclusions: Our findings indicate that in house painters, occupational exposure to isocyanates has no effect on bronchoalveolar epithelial permeability, and the rate of Tc-99m DTPA clearance shows no difference between asthmatic and non-asthmatic house painters. The positive correlation between the rate of Tc-99m DTPA clearance and work duration needs to be confirmed in larger cohorts.Öğe A case of acute tubular necrosis with intestinal visualization of Tc-99m DMSA(Lippincott Williams & Wilkins, 2000) Yüksel, M; Üstün, F; Salan, A; Sen, S; Berkarda, S[Abstract Not Available]Öğe Comparison with clearance of Tc-99m DTPA aerosol, and CO diffusing capacity, and lung function test in house painters(Springer-Verlag, 2001) Kaya, M; Salan, A; Tabakoglu, E; Aydogdu, N; Yüksel, M; Salihoglu, YS; Yigitbas, ON[Abstract Not Available]Öğe Extensive bone metastases in a patient with prostatic adenocarcinoma and normal serum prostate-specific antigen and prostatic acid phosphatase(Lippincott Williams & Wilkins, 2001) Yuksel, M; Çermik, TF; Kaya, M; Salan, A; Ustun, F; Salihoglu, YS; Yigitbasi, ÖN[Abstract Not Available]Öğe Monitoring the chemotherapeutic response in primary lung cancer using 99mTc-MIBI SPET(Springer-Verlag, 2001) Yüksel, M; Çermik, TF; Karlikaya, C; Salan, A; Çakir, E; Gültekin, A; Berkarda, FPrediction and evaluation of the response to chemotherapy (CTx) are important for the correct and cost-effective treatment of patients with primary lung cancer. Although fluorine-18 fluorodeoxyglucose. positron emission tomography (FDG-PET) is accepted as the most useful and accurate nuclear medicine technique for this purpose, its expense and limited availability restrict its use. Compared with PET agents, technetium-99m methoxyisobutylisonitrile (MIBI), which is used in nuclear oncology, is cheaper and available in any nuclear medicine clinic. With this in mind, in this study we aimed to evaluate the role of Te-99m-MIBI in monitoring the chemotherapeutic response in primary lung cancer. Twenty patients with primary lung cancer underwent Tc-99m-MIBI single-photon emission tomography (SPET) at 15 min (early) and 3-4 h (delayed) after injection of the tracer. All patients underwent 99mTc-MIBI SPET study twice: before and after the 3rd cycle of CTx. Patients were divided into two groups, responders [R(+), n=10] and nonresponders [R(-), n=10], according to the change in tumour size on CT scan taken 2 weeks after the last cycle of the CTx. From the SPET images early and delayed tumour/lung ratios (ER and DR) were obtained before and after CTx. In the R(+) group, ER and DR decreased significantly after CTx, from 3.28 +/-1.55 to 1.78 +/-0.72 (P <0.04) and from 3.23 +/-1.55 to 2.0 +/-0.88 (P <0.05), respectively. However, in the R(-) group, while ER showed a slight and statistically insignificant increase after CTx (from 2.51 +/-1.23 to 2.65 +/-1.86), DR increased significantly, from 2.74 +/-1.37 to 3.27 +/-2.31 (P <0.03). The percentage decreases in ER and DR in the R(+) group after CTx was significantly higher than that in the R(-) group: 34.36%+/- 26.7% vs -13.78%+/- 27.58% (P <0.0002) and 29.45%+/- 25.23% vs -18.58%+/- 20.51% (P <0.0005), respectively. Using a decrease of greater than or equal to 10% as a threshold for monitoring the chemotherapeutic response, Te-99m-MIBI had a sensitivity of 90% and a specificity of 100%. We found a positive correlation in 14 patients between ER and DR and survival: r=0.6754 and P=0.008, and r=0.5755 and P=0.031, respectively. Our results suggest that Te-99m-MIBI might be used in routine practice to monitor the chemotherapeutic response in patients with primary lung cancer, especially when PET is not available.Öğe The relationship between Tc-99m MIBI uptake and chemotherapeutic response, metastasis, Pgp, p53, and prognosis in lung cancer(Springer-Verlag, 2001) Yüksel, M; Çermik, TF; Doganay, L; Karlikaya, C; Salan, A; Çakir, E; Ture, M[Abstract Not Available]Öğe Tc-99m MDP and Tl-201 scintigraphy in a case of metastatic meningeal hemangiopericytoma(Lippincott Williams & Wilkins, 2001) Kaya, M; Cermik, TF; Hacimahmutoglu, S; Salan, A; Saridogan, K; Cakir, B; Yigitbasi, ON[Abstract Not Available]Öğe Tc-99m MDP bone scintigraphy in a patient with multicentric osteosarcoma(Lippincott Williams & Wilkins, 2003) Çermik, TR; Salan, A; Firat, MF; Berkarda, S[Abstract Not Available]Öğe Tc99m sestamibi muscle scintigraphy to assess the response to electrical stimulation and isometric exercise of quadriceps femoris muscle(Springer-Verlag, 2001) Pekindil, Y; Birtane, M; Sankaya, A; Salan, A; Kokino, S[Abstract Not Available]Öğe Tc99m-HMPAO brain SPECT in children with visual impairment(Springer Verlag, 1999) Kaya, M; Esgin, H; Karasalihoglu, S; Altun-Durmus, G; Sarikaya, A; Salan, A; Saliboglu, YS[Abstract Not Available]Öğe Tl-201 uptake and its relationship with chemotherapeutic response, metastasis, p53 status, and survival in primary lung cancer(Springer-Verlag, 2001) Çermik, TF; Yüksel, M; Karlikaya, C; Doganay, L; Çakir, E; Salan, A; Ture, M[Abstract Not Available]