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    Early Serum Heme Oxygenase-1, Soluble Vascular Endothelial Growth Factor Receptor-1, and B-Cell Lymphoma/Leukemia-2 Levels and Unfavorable Obstetric Outcomes
    (2022) Sütçü, Havva; Varol, Füsun; İnan, Cihan; Uzun, Işıl; Sayın, Cenk
    OBJECTIVE: To examine early pregnancy levels of serum heme oxygenase-1, soluble vascular endothelial growth factor receptor-1, B-cell lymphoma/leukemia-2 in relation to unfavorable pregnancy outcomes, including preeclampsia, fetal growth restriction, spontaneous preterm birth, gestational diabetes mellitus and fetal macrosomia. STUDY DESIGN: A total of randomly selected 140 pregnancies were included in this prospective study. Peripheral blood samples were obtained between 110/7 and 136/7 gestational weeks. All pregnancies were followed up until the outcomes were obtained and classified as preeclampsia, fetal growth restriction, spontaneous preterm birth, gestational diabetes mellitus, fetal macrosomia, and uncomplicated ones. RESULTS: Significantly high levels of early serum heme oxygenase-1 were found in the cases who subsequently developed preeclampsia, spontaneous preterm birth, and fetal macrosomia (p<0.05), in concordance with high soluble vascular endothelial growth factor receptor-1 levels of the preeclampsia group, however, B-cell lymphoma/leukemia-2 s were similar in all groups. As soluble vascular endothelial growth factor receptor-1 predicted preeclampsia at a value of 11.905 ng/mL, the cutoff values for the heme oxygenase-1 to predict preeclampsia, spontaneous preterm birth, and fetal macrosomia were 0.372 ng/mL, 0.354 ng/mL and 0.494 ng/ml, respectively. CONCLUSION: Elevated first trimester heme oxygenase-1 levels are remarkable in the pregnancies associated with preeclampsia, spontaneous preterm birth, and fetal macrosomia in comparison with uncomplicated ones.
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    MEASUREMENT OF FETAL NASAL BONE LENGTH, PRENASAL THICKNESS AND CORPUS CALLOSUM LENGTH OF FETUSES IN THRACE REGION OF TURKEY
    (2020) Varol, Füsun; Yener, Cem; Sütçü, Havva; Altan, Esra; Ateş, Sinan; Sayın, Cenk
    Aim: The nasal bone can be imaged with ultrasonography from the 10th week of pregnancy. In situations where the nasal bone isaplastic or hypoplastic, the risk of chromosomal anomalies increases. Thickening of the prenasal soft tissue is also apparent in the vastmajority of second-trimester fetuses with Down syndrome. In addition to these, corpus callosum is an another fetal structure that can bevisualized from 18th weeks of the gestation by ultrasound. Agenesis or dysgenesis of it is related with neuro-disabilities. In this study ourobjective was to provide reference charts for fetal nasal bone length, prenasal thickness and corpus callosum length obtained byprenatal sonography between 19th and 23rd weeks of pregnancy.Materials and Methods: The medical records of pregnant women who were followed-up in Trakya University School of Medicine,Department of Obstetrics & Gynecology, Division of Perinatology during the time period of 1st of January 2018 to 31st of December2019 were reviewed retrospectively. We studied 167 patients in between 19th and 23rd weeks of pregnancy.Results: Nasal bone length, prenasal thickness and corpus callosum length increased as the gestation proceeded. Mean±SD for nasalbone length, prenasal thickness and corpus callosum length (mm) between 19th and 23rd weeks were 6.65±0.7, 4±0.5, 20.1±1.4respectively.Conclusion: Ultrasound measurements of nasal bone length, prenasal thickness and corpus callosum can be performed within thesecond-trimester anomaly scan, and these measurements appear to be highly necessary because these measurement sensitive forprenatal diagnosis of chromosomal abnormalities and genetic syndromes.