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Öğe Color stability of bulk-fill resin composites exposed to caffeinated beverage: An in vitro study(Mosher & Linder, Inc, 2022) Ozyurt, Esra; Kurt, AysegulPurpose: To evaluate the in vitro color stability and surface properties of bulk-fill resin composites after exposure to coffee and cola. Methods: Color stability was evaluated in a conventional resin composite (Filtek Z250) and three bulk-fill resin composites (Filtek One Bulk Fill, Tetric N-Ceram Bulk Fill, and Beautifil Bulk Fill as giomer). Color change (CIEDE 2000 AE00) was calculated after 12 days of immersion in distilled water (control), coffee, or cola (Diet Coke). Water sorption (%Wsp) and solubility (%Wsl) ratios were calculated for each material in each solution. One sample of each material from each condition was observed with scanning electron microscopy and atomic force microscopy. Generalized linear modeling and Bonferroni correction were used for AE00 value analysis. One-way ANOVA and Kruskal Wallis tests were performed to analyze %Wsp and %Wsl ratios. Results: Tetric N-Ceram Bulk Fill showed the highest AE00 value in distilled water. Beautifil Bulk Fill had the highest AE00 value in coffee and cola. Beautifil Bulk Fill had the highest %Wsl ratio. Filtek One Bulk Fill and Tetric N -Ceram Bulk Fill had the highest and lowest %Wsp ratios, respectively. Coffee and cola exposure had surface property-disrupting and discoloration effects on both conventional and bulk-fill resins.Öğe Comparison of Medicaments Used in Regenerative Endodontics in Terms of Dentin Microhardness and Adhesion of Mineral Trioxide Aggregate(Univ Indonesia, Fac Dentistry, 2020) Saricam, Esma; Bulak, Neslihan; Ozyurt, Esra; Ozcan, SuatEliminating microorganisms in the root canal system is important for the success of regenerative endodontics. Objective: This study evaluated the effects of different antibiotic pastes used for regenerative endodontic procedures on dentin microhardness and the push-out bond strength of mineral trioxide aggregate (MTA) to root canal dentin. Methods: Sixty-four maxillary central incisors were instrumented and randomly divided into the following four groups (n = 16) for medicament treatment: triple antibiotic paste, amoxicillin+clavulanic acid, cefaclor, and control (no dressing). After 21 days, two root segments were obtained by sectioning the roots horizontally for push-out and microhardness evaluations. MTA was placed into the root canal of the sectioned segment for the push-out test. In the microhardness evaluation, three indentations were made at 500 and 1,000 mu m from the canal lumen. The arithmetic mean was then calculated for each distance. ANOVA with post hoc Scheffe test and t test were used for the statistical analyses. The significance level was set at p < 0.05. Results: No significant difference was found between the groups in terms of push-out bond strength (p > 0.05). Cefaclor and amoxicillin+clavulanic acid reduced the microhardness values of the dentin at 500 mu m (p < 0.05) while cefaclor had the lowest value at 1,000 mu m (p < 0.05). Conclusion: Cefaclor reduced the microhardness value more than the other medicaments did at a depth of 1,000 mu m. The pastes provided similar adhesion of MTA.Öğe Effect of different beverages on color stability and surface properties of composite resin materials(Wiley, 2021) Ozyurt, Esra; Kurt, AysegulThe aim of this in vitro study was to investigate the effect of frequently consumed beverages on the color stability and surface properties of direct and indirect dental composite materials. The two dental composite materials (direct and indirect) and four beverages (distilled water, tea, coffee, cola) were assessed. The specimens were prepared for evaluating monomer conversion, water sorption, and color stability (n = 10) and taking scanning electron and atomic force microscopy images (n = 3). The data were analyzed using independent t-test, Mann-Whitney U test, two-way analysis of variance, and Spearman's correlation (P < .05). Indirect dental composite materials had better monomer conversion, color stability, and surface roughness value when compared to direct dental composite materials (P < .001, P = .002, P = .002, respectively). The control group had lower Delta E-00 values when compared to the tea (P < .001) and coffee (P < .001) groups. There was a negative correlation between monomer conversion and surface roughness (r = -0.481, P = .032). Color stability and surface roughness value of direct dental composite materials differed from indirect dental composite materials after immersed in different beverages. The tested beverages significantly influenced color stability.Öğe Effect of different beverages on surface properties and cariogenic biofilm formation of composite resin materials(Wiley, 2021) Kurt, Aysegul; Ozyurt, Esra; Topcuoglu, NursenThe consumption of certain beverages may affect the physical and biological properties of resin composites (RCs) according to type. This in vitro study aimed to evaluate the surface properties and cariogenic biofilm formation in microhybrid and nanohybrid RCs after immersion in different beverages. The effects of four beverages (distilled water-control, tea, coffee, and cola) on two RCs (microhybrid and nanohybrid) were evaluated. Changes in the surface properties were evaluated for each group using surface roughness measurement (n = 10), scanning electron microscopy (SEM) (n = 4) observation, and energy-dispersive X-ray spectroscopy (EDX) (n = 5) analysis. In vitro Streptococcus mutans biofilm formation on the specimens of each group was determined using confocal laser scanning microscopy and SEM analysis (n = 14). The data were analyzed using two-way analysis of variance, with Bonferroni as a post-hoc test and Pearson's correlation (p < .05). Microhybrid RC presented more surface roughness (p = .014) and cariogenic biofilm formation (p = .040). The surface roughness (F = 0.733, p = .536) and cariogenic biofilm formation (F = 1.685, p = .181) values were not affected by the beverages. However, according to qualitative SEM and EDX measurements, these parameters varied depending on the beverage groups. No correlation was found between surface roughness and cariogenic biofilm formation (r = 0.135, p = .287). Microhybrid RCs had a rougher surface and a higher amount of cariogenic biofilm formation than nanohybrid RCs after being subjected to different beverages.Öğe Evaluation of the Polymerization Depth of Bulk Fill Resin Composites Polymerized by Different Procedures: An In-Vitro Study(Marmara Univ, Inst Health Sciences, 2019) Ozyurt, Esra; Kurt, Aysegul; Yildirim, HandanObjective: The aim of this study is to investigate the depth of cure (DOC) of the bulk fill composite samples prepared in different thicknesses with two different modes of light curing device with Vickers hardness tester. Methods: Five different bulk-fill composite materials were used in the present study. 20 sample of 2 mm and 20 sample of 4 mm thick samples were prepared, 10 samples from each group were polymerized for 20 seconds with the standard mode (Mode 1) of the light curing device and 10 samples polymerized with soft-start mode (Mode 2) for 25 seconds (n=10). Hardness measurements were made from the upper and lower surfaces of each sample and the hardness ratio was calculated. The statistical analysis was performed using three-way analysis of variance (ANOVA) and Tukey multiple comparisons (p = 0.05). Results: The hardness ratios of all composites were determined to be over 80%, which is clinically acceptable. There was a statistically significant difference between the DOC levels according to the composites (p<0.05). There was a statistically significant difference according to the thickness (p<0.05). There was no statistically significant difference according to polymerization procedures (p>0.05). Conclusions: The surface hardness ratios of all groups were determined to be over 80%, which is clinically acceptable. The polymerization with soft start technique may not different from the standard-mode for polymerization depth.Öğe In Vitro Comparison of the Effectiveness of a Resin Infiltration System and a Dental Adhesive System in Dentinal Tubule Penetration(Marmara Univ, Inst Health Sciences, 2019) Ozyurt, Esra; Arisu, Hacer Deniz; Turkoz, EminObjective: The aim of this study was to assess and compare the dentin tubule penetration effectiveness of a dental adhesive and a resin infiltration system used with two different surface treatments. Methods: Dentin specimens were obtained from 42 impacted lower right wisdom tooth, 2 of these specimens were used to detect the effects of surface treatments. Two different surface treatments (37% phosphoric acid and 17% EDTA) were applied to the samples to compare the dentin tubule penetration effectiveness of a dental adhesive -which had been using for treatment of dentin hypersensitivity - and a resin infiltration system. Scanning electron microscopy was used to investigate the tubule penetration effectiveness. For statistical analysis, Kruskal Wallis and Mann Whitney U and One Way Analysis of Variance (ANOVA) and Tukey HSD tests were used. Results: ICON had shown significantly more resin penetration intensity and more resin penetration depth than Adper Single Bond 2 (p<0.05). Phosphoric acid treatment groups had shown significantly more penetration intensity than EDTA treated groups (p=0.001). Conclusion: According to the results of this study, it can be concluded that tubuler penetration effectivenes of ICON resin infiltration system is better than Adper Single Bond 2 adhesive system.Öğe Instrumental and visual evaluation of the color adjustment potential of different single-shade resin composites to human teeth of various shades(Springer Heidelberg, 2023) Altinisik, Hanife; Ozyurt, EsraObjective The study aims to evaluate the color adjustment potential (CAP-I, CAP-V) of different single-shade resin composites. Materials and methods The shades of 40 human incisors were determined using a spectrophotometer, with the teeth divided into four groups of the same shade (n = 10). The following single-shade resin composites were tested: Omnichroma, Charisma Diamond One, Vittra Unique, and Essentia Universal. The specimens were prepared as dual and single. Standardized cavity preparations (diameter, 7 mm; depth, 2 mm) were prepared in human incisor teeth and then restored for dual specimens. Composite duplicates of human incisors were prepared with resin composites for single specimens (n = 10). The color match of these specimens to that of unrestored human incisors was compared, and the color difference (Delta E*) was calculated. Independent observers conducted a visual evaluation of the specimens and scored them. CAP-I and CAP-V values were determined. A one-way analysis of variance test was used for statistical analysis (p < 0.05). Results There was no statistically significant difference between the CAP-V and CAP-I values of the tested single-shade resin composites (p > 0.05). All the materials tested had acceptable color-matching potential. Conclusions In terms of color matching, there were no significant differences between the different tooth shades of all the tested resin composites.Öğe Investigation of microleakage in adhesive restorations under hyperbaric conditions: An in vitro study(Elsevier Sci Ltd, 2023) Ozyurt, Esra; Altinisik, HanifeIn underwater and hyperbaric oxygen therapy chambers, hyperbaric environments may cause dislodgement or crack on dental restorations. This study aimed to investigate microleakage in different bonding techniques under hyperbaric conditions. Class II cavities were prepared on sixty human molar teeth. According to the manufac-turer's instructions, a universal adhesive was applied to half of the samples with the self-etch technique, and the selective-etch technique to the other half, then light-cured. The cavities were restored with a conventional resin composite. The two main groups were divided into subgroups for hyperbaric conditions as control (1-bar), 2.8 -bar, and 4-bar air pressure. The samples were immersed in a 1% methylene blue dye solution and then sectioned. Microleakage was evaluated under a stereomicroscope. Data were analyzed with the Chi-square test and Fisher's Exact Chi-square test with a p < 0.05 significance level. The 4-bar groups showed significantly higher micro -leakage scores than the control and 2.8-bar groups among each selective-etch and self-etch subgroups (0.009, 0.000 respectively). In the 4-bar groups, The self-etch subgroup score was significantly higher than the selective -etch subgroup under 4-bar pressure (p < 0.05). The selective-etch technique for universal adhesive showed better results against microleakage under hyperbaric conditions.Öğe Side effects of immune-checkpoint inhibitors: Can multiple side effects be seen in a patient?(Sage Publications Ltd, 2022) Ozyurt, Esra; Ozcelik, Serhat; Surmeli, Heves; Celik, Mehmet; Ayhan, Murat; Ozcelik, MelikeIntroduction Nivolumab is a human immunoglobulin G4 monoclonal antibody that inhibits programmed cell death-1 activity by binding to the programmed cell death-1 receptors. Cancer cells express increased number of programmed cell death-1 ligands and this allows them to escape the cytotoxic effects of the T cells. Therefore, the negative programmed cell death-1 receptor signal regulates T-cell proliferation and activation is disrupted. However, this change in the activity of the T cells can cause them to lose their ability to recognize host cells. The immune response enabled by these agents has led to side effects, commonly known as immune-related adverse events. Case report We report a case of a 66-year-old male patient who was treated with nivolumab for recurrent renal cell carcinoma presented with hepatitis and adrenalitis. Three weeks after starting nivolumab, the patient had abdominal pain and weakness, and then aspartate and alanine transaminase levels were found to be elevated. Management and outcome Hepatitis was predicted to be due to nivolumab, because other causes were excluded. He started using oral methylprednisolone and then, hepatitis improved. However, while receiving methylprednisolone treatment, fludrocortisone was started with the pre-diagnosis of adrenalitis due to the persistence of fatigue, weakness, and hyponatremia and hyperkalemia. With both treatments, the patient's symptoms and sodium and potassium level returned to normal. Discussion This case emphasizes the need for patient's education and awareness of immune-related adverse events, and the importance of understanding the management of life-threatening complications of the checkpoint inhibitors, because these side effects require prompt recognition and treatment.
