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Öğe ASSESSMENT OF TEN-YEAR-LONG RESULTS OF KIDNEY BIOPSIES PERFORMED ON CHILDREN IN THE THRACE REGION OF TURKEY(Springer, 2015) Ozkayin, Nese; Ciplak, Gokce; Usta, Ufuk; Genchellac, Hakan; Temizoz, Osman[Abstract Not Available]Öğe Association of FAS-670A/G and FASL-843C/T Gene Polymorphisms on Allograft Nephropathy in Pediatric Renal Transplant Patients(Iranian Scientific Society Medical Entomology, 2010) Ertan, Pelin; Mir, Sevgi; Ozkayin, Nese; Berdeli, AfigObjective: FAS and FASL polymorphisms are suggested to play an important role in tubulitis that is a major component of acute rejection. The aim of this study was to investigate the role of FAS-670A/G and FASL-843C/T gene polymorphisms on allograft nephropathy in pediatric renal transplant patients Methods: Fifty three patients (22 males 31 females) aged 2 to 20 years (mean 12.3 +/- 0.6) who had renal transplantation and fifty healthy control subjects (25 males 25 females) were enrolled in the study. Pearson's Chi Square test was used for the statistical analysis. Survival rates were estimated with the Kaplan Meier method. Age, sex, chronic renal failure etiology, treatment modality and duration and donor type were recorded. FAS-670A/G and FASL-843C/T gene polymorphisms were compared between renal transplant patients and normal healthy population as well as between renal transplant patients with and without acute rejection. Findings: FAS-670A/G genotypes or alleles were not significantly different between control and transplant patients and among transplant patients with and without acute rejection (P>0.05 for all). FASL-843C/T genotypes and alleles were not different between transplantation and control groups (P>0.05 for all). However, FASL-843C/T alleles were significantly different between patients with and without AR (P=0.02). The percentages of C allele were higher in children with acute rejection (68.8% vs 44.6%). Conclusion: FASL gene polymorphisms may play a major role in acute rejection while FAS polymorphisms have not been found to be different between patients with and without acute, renal graft rejection.Öğe A CASE WITH INFANTILE HYPOPHOSPHATASIA PRESENTING WITH SEVERE HYPERCALCEMIA AND PSEUDOTUMOR CEREBRI(Karger, 2017) Tutunculer, Filiz; Mutlu, Kibar; Uguz, Ayse; Yildiz, Raif; Ozkayin, Nese[Abstract Not Available]Öğe Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study(Springer, 2024) Dogan, Cagla Serpil; Taner, Sevgin; Tiryaki, Betul Durucu; Alaygut, Demet; Ozkayin, Nese; Kara, Aslihan; Gencler, AylinBackground Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.Methods Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1-5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m2 but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.Results A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1-4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2-18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658-0.859; p < 0.001; OR 1.187; 95% CI 1.031-1.367; p = 0.017; OR 10.031; 95% CI 2.210-45.544; p = 0.003; OR 2.722; 95% CI 1.215-6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.Conclusion MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.Öğe The clearance time of infused hematopoietic stem cell from the blood circulation(Pergamon-Elsevier Science Ltd, 2013) Donmez, Ayhan; Ozsan, Fatma; Arik, Bahar; Ozkayin, Nese; Cagirgan, Seckin; Mir, Sevgi; Vural, FilizThere is no detailed information about the clearance time of infused hematopoietic stem cell (HSC) from the blood circulation in humans. In this prospective study, peripheral blood CD34+ cell counts were detected during the 4 days period following autologous HSC transplantation in 20 patients by means of flow cytometry. The median CD34+ cells were at the highest level in the first hour and decreased below pre-infusion values on the first day after HSC infusion. By nonparametric analysis, positive correlation was found between CD34+ cell levels at the first hour and the post-thaw CD34+ cell dose (r = 0.57, p = 0.01). An inverse correlation was determined between CD34+ cell levels at the first hour and neutrophil engraftment (r = -0.54, p = 0.01). Compared with the patients having CD34+ cell count of >= 2 mu L-1 in the first hour following HSC infusion, the patients having CD34+ cell count of <2 mu L-1 had delayed both neutrophil (20 vs. 12, p = 0.008) and platelet (47 vs. 11, p = 0.01) engraftments. Our results indicated that infused HSCs were removed from the blood circulation within 1 day. In addition, CD34+ cell levels at the first hour may be used as an important indicator to predict the delay of neutrophil and platelet engraftments. (c) 2013 Elsevier Ltd. All rights reserved.Öğe Complicated xanthogranulomatous pyelonephritis in a child(Wiley-Blackwell Publishing, Inc, 2010) Ozkayin, Nese; Inan, Mustafa; Aladag, Nukhet; Kaya, Meryem; Iscan, Burcin; Yalcin, Omer[Abstract Not Available]Öğe Enuresis(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2007) Kaptan, Bulent; Ozkayin, NeseEnuresis is an unvoluntary miction that is seen after 5 years of aye when the sphincter control is expected to be developed. It is recommended to be called as delayed or complicated toilet education before five years of age. Genetic factors are the most claimed etiologic cause. Detailed history must be taken and a complete physical examination must be done for the evaluation of children with enuresis. Children and family education is the most important point on treatment. The families of children who era under 5 years of age must be informed about the causes, prevalence, prognosis and the reversibility of enuresis and it is recommended to seek me dical advice if they still have the sauna problem. The time of asking the doctor is very important on enuresis treatment. In sonic of the cases, there was significant improvement just after making an appointment with a doctor. Treatment choices can be divided into two groups as pharmacological or nonpharmacological. Nonpharmacological methods must be the first choice, Alarm equipments are considered as the most effective treatment method. Imiprarnine, desmopressin and anticholinergics are used in pharmacologi cal therapy. When immediate effect is needed, desrnopressin is the first choice; and if there is depression, sleep disorders and attention deficit with enuresis imipramine is the first choice.Öğe Evaluation of health-related quality of life and affecting factors in child with enuresis(Elsevier Sci Ltd, 2020) Iscan, Burcin; Ozkayin, NeseBackground Enuresis is a common problem in children and distressing condition that can have an impact on the child's behavior and on their emotional and social life. Health-related quality of life (HRQoL) is defined as an individual's perception of the impact of the disease and treatment. Objective The aim of this study was to evaluate the HRQoL in Turkish children with enuresis and to investigate the effect of independent sociodemographic and clinical variables on HRQoL in children with enuresis. Study desing 110 children with enuresis and their mothers and 120 healthy children and their mothers were included in the study. The German quality of life questionnaire (KINDL (R)) scales were used to assess the children's HRQoL. For comparing the data of children with enuresis and healthy children, a two-sided unpaired t-test and linear regression model were used. Result The total HRQoL score for the children with enuresis group was 63.14 +/- 21.98 and for the children in the control group was 75.6 +/- 10.1 (P < 0.001). After adjusting for sex and age using the unstandardized coefficient of regression model, HRQoL score for the children with enuresis still remained statistically significant lower than that for healthy peers (64.21 +/- vs 75.11 +/- P < 0.001). The HRQoL subscale scores showed that children with enuresis had lower emotional well-being scores (64.23 +/- 14.2 vs 78.9 +/- 11.4, P < 0.001), self-esteem score (62.23 +/- 11 vs 68.6 +/- 17.4, P = 0.001), family relationship score (76.23 +/- 2 vs 83.4 +/- 12.2, P = 0.042), and friendship score (62.4 +/- 13.2 vs 68.8 +/- 15.3, P = 0.023) compared to the control group. When the effects of independent sociodemographic factors and clinical variables on HRQoL were evaluated, it was seen that the presence of lower urinary tract symptoms (LUTS) negatively affected total HRQoL score (59.89 +/- 11.2 vs 69.29 +/- 10.9 P = 0.028). Also the total HRQoL score was higher in treated children with enuresis than in nontreated children (65.96 +/- 12.1 vs 55.27 +/- 10.1 P = 0.032). Among the treated children, complete treatment response group had higher total HRQoL score compared to partial treatment response group and nonresponse group (respectively, 70.98 +/- 9.7, 65.25 +/- 10.1, 60.45 +/- 10.9, P = 0.034, P = 0.01) (Summary Figure). Family income level affected total HRQoL score, low-income group had lower total HRQoL score compared to high-income group (62.17 +/- 11.9 vs 69.25 +/- 10 P = 0.039). Discussion This study demonstrated that enuresis negatively affects the HRQoL of children and most affected domains in HRQoL were self-esteem, emotional well-being, and their relationship for family and friends. Our presented study showed that HRQoL was lower in non-primary monosymptomatic nocturnal enuresis (non-PMNE) children, nontreated patients. Also there were higher HRQoL scores in patients who had a total or partial response to treatment. Conclusion Our study may indicate that, low-income children with enuresis, nontreated enuretic children, and presence of LUTS should be considered as a risk group for low HRQoL.Öğe FOLLOW-UP AND RESULTS OF OUR VESICOURETERAL REFLUX DISEASES(Springer, 2018) Karaca, Zeynep; Ozkayin, Nese; Basaran, Umit; Inan, Mustafa; Aksu, Burhan; Altun, GUlay; Kucuk, Funda[Abstract Not Available]Öğe Mediterranean Fever Gene Mutations and Messenger Ribonucleic Acid Expressions in Pediatric Patients With Familial Mediterranean Fever in the Trakya Region of Turkey(Turkish League Against Rheumatism, 2014) Tozkir, Hilmi; Gusrkan, Hakan; Ozkayin, Nese; Sut, NecdetObjectives: This study aims to investigate the possible relationship between Mediterranean fever (MEFV) gene mutations and messenger ribonucleic acid (mRNA) expressions and to identify the link between phenotype and genotype of pediatric patients with Familial Mediterranean fever (FMF). Patients and methods: Seventy-one pediatric FMF patients who were identified with FMF symptoms and diagnosed with FMF according to Tel Hashomer criteria were included at Trakya University, Faculty of Medicine, Department of Paediatric Nephrology. The control group consisted of 73 healthy pediatric participants. Genomic deoxyribonucleic acid was isolated from whole blood samples and the following mutations of MFEV gene were analyzed: E148Q, P369S, H478Y, H479L, S675N, G678E, M680L, M680I (G>A and G>C), T681I, I692del, M694V, M694L, M694I, M695R, M695M, R717S, I720M, V722M, V726A, A744S and R761H. Total RNA isolation from leukocytes was performed and MEFV mRNA expression levels of the patients were compared by using real-time quantitative polymerase chain reaction method. beta 2 microglobulin was selected as the control gene. The comparison of mRNA expression levels among the patients was performed using the Delta CT method. Results: The most common clinical findings were abdominal pain, fever and vomiting. The mutation detection rate in the patient group was OR=4.1 (95% CI: 1.8-9.0) times higher than that of the control group. The MEFV mRNA expression level of the patients with MEFV gene mutations was lower compared to the control group, indicating statistical significance. Conclusion: Our study results support the findings of previous studies indicating that the MEFV mRNA expression levels of pediatric FMF patients with MEFV gene mutation are lower than the MEFV mRNA expression levels of healthy controls.Öğe Parvovirus Infection in a Child Presenting with Erythema Multiforme and Vasculitis after a Yellow Jacket Bee Sting(Oxford Univ Press, 2021) Can, Ceren; Yazicioglu, Mehtap; Gokalp, Selman; Ozkayin, NeseParvovirus B19 has a wide spectrum of clinical manifestations. Erythema multiforme and vasculitis are rarely reported with parvovirus B19 infections. Reactions to insect stings can range from local swelling to life-threatening systemic reactions. There have been rare reports of unusual reactions, such as vasculitis, occurring in a temporal relationship with insect stings. We report an 8-year-old patient having Parvovirus B-19-related erythema multiforme and vasculitis after a yellow jacket bee sting.Öğe RITUXIMAB TREATMENT FOR DIFFICULT-TO-TREAT NEPHROTIC SYNDROME IN CHILDREN: A MULTICENTER STUDY(Springer, 2018) TaSdemir, Mehmet; Canpolat, Nur; Yildiz, Nurdan; Ozcelik, Gul; Benzer, Meryem; Saygili, Seha Kamil; Ozkayin, Nese[Abstract Not Available]Öğe TEN YEAR FOLLOW-UP RESULTS OF CHILDREN DIAGNOSED WITH HENOCH SCHONLEIN PURPURA IN TRAKYA REGION(Springer, 2018) Orencik, Aysegul; Ozkayin, Nese[Abstract Not Available]
