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Öğe Atypical patterns of the de Winter sign: even more confusion in clinical practice(Polish Cardiac Soc-Polskie Towarzystwo Kardiologiczne, 2021) Yalta, Kenan; Ozkan, Ugur; Yetkin, Ertan[Abstract Not Available]Öğe Cardiac myxoma as a potential trigger of takotsubo cardiomyopathy: A brief review on mechanistic and clinical perspectives(Pagepress Publ, 2022) Yalta, Tulin; Yalta, Kenan; Ozkan, Ugur; Yetkin, ErtanIn clinical practice, cardiac myxomas constitute the majority of benign cardiac neoplasms, and might potentially present with a variety of embolic, obstructive as well as constitutional symptoms. On the other hand, these neoplasms might be potentially associated with the evolution of takotsubo cardiomyopathy (TTC) that is universally considered as a transient form of acute myocardial dysfunction. Accordingly, the present paper primarily aims to focus on potential mechanisms and associated clinical implications of TTC evolution in the setting of cardiac myxomas.Öğe Cardiac myxomas in an unusual location: A glimpse into their potential characteristics(Aves, 2021) Yalta, Kenan; Ozkan, Ugur; Yalta, Tulin; Yetkin, Ertan[Abstract Not Available]Öğe Comparison of Myocardial Perfusion Scintigraphy and Coronary Angiography Results in Breast Cancer Patients Treated with Radiotherapy(Mdpi, 2023) Ozkan, Ugur; Gurdogan, MuhammetBreast cancer is the most common type of malignancy in women and radiotherapy (RT) is an important part of treatment. Although it reduces cancer recurrence, it has been shown to cause accerelerated athnerosclerosis. This study aimed to compare the results of myocardial perfusion scintigraphy (MPS) for ischemia investigation with coronary angiography (CAG) findings and to investigate the effect of RT on the development of coronary artery disease in breast cancer patients who underwent RT. The results of 660 patients were analyzed and compared with each other in terms of clinical, demographic, laboratory parameters and MPS results. The mean age was 57.5 years and all of them were female. When the groups were compared, the Gensini score and marking of the left anterior descending artery (LAD) area as ischemic area localization were found more, but angiographically, the rate of severe stenosis in the area indicated by MPS was found to be lower in the RT group (p < 0.001). While the sensitivity of MPS in the RT group was 67.5% and non-RT group was 88.5% (p < 0.001), the result of our study shows that the sensitivity of the MPS test is significantly lower in the patient group receiving RT.Öğe Correspondence on Sodium-glucose co-transporter 2 inhibitor therapy: mechanisms of action in heart failure by Joshi et al(Bmj Publishing Group, 2021) Yalta, Kenan; Ozkan, Ugur; Yalta, Tulin[Abstract Not Available]Öğe The Effect of SGLT2 Inhibitors on the Development of Contrast-Induced Nephropathy in Diabetic Patients with Non-ST Segment Elevation Myocardial Infarction(Mdpi, 2023) Ozkan, Ugur; Gurdogan, MuhammetBackground and Objectives: Percutaneous procedures using contrast agents are modern diagnosis and treatment methods for cardiovascular diseases. Contrast use may cause nephropathy, especially in diabetic patients. SGLT2 inhibitors have strong cardioprotective and renal protective effects. In our study, we investigated the effectiveness of this drug group in preventing the development of Contrast-Induced Nephropathy (CIN). Materials and Methods: The results of 312 diabetic patients who underwent CAG were analyzed. The study group included 104 DM patients using SGLT2 and the control group did not use SGLT2. These groups were compared with each other in terms of clinical, demographic, and laboratory parameters. Results: The groups were similar characteristics. However, post-CAG creatinine values compared with before the procedure, the development of CIN was observed to be significantly less in the group using SGLT2 inhibitor (p = 0.03). When the results of the multivariate analysis were examined, it was seen that the use of SGLT2 inhibitors significantly reduced the risk of CIN (odds ratio (OR): 0.41, 95% confidence interval (CI): 0,142-0.966, p = 0.004). Conclusions: Our study showed that SGLT2 inhibitors may be protective against the development of CIN, especially in patients with comorbid conditions such as diabetes.Öğe First Experience of Cardiac Device Implantation with Remote Cardiac Support System in Turkey(Galenos Publ House, 2022) Taylan, Gokay; Gok, Murat; Ozkan, Ugur; Altay, Servet; Yalta, Kenan[Abstract Not Available]Öğe Intracoronary fibrinolysis: An effective yet underutilized therapeutic strategy in clinical practice(Aves, 2021) Yalta, Kenan; Ozturk, Cihan; Yalta, Tulin; Ozkan, Ugur[Abstract Not Available]Öğe Kawasaki disease: Specific considerations in the management of coronary artery sequelae(Elsevier Espana Slu, 2022) Yalta, Kenan; Ozkan, Ugur; Yalta, Tulin; Yetkin, Ertan[Abstract Not Available]Öğe Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification(Mdpi, 2019) Ozkan, Ugur; Ozcelik, Fatih; Yildiz, Mustafa; Budak, MetinCalcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental and genetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying from mild valve thickening to severe valve calcification and stenosis. Progression of the disease consists of chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similar to coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphisms associated with calcific aortic stenosis from blood samples after echocardiography in the evaluation of 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to rule out certain risk factors before echocardiography examination. A significant association among smoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, and rs3798220 polymorphisms may be considered genetic risk factors for the development of calcific aortic stenosis.Öğe A Novel Potential Biomarker for Predicting the Development of Septic Embolism in Patients with Infective Endocarditis: Systemic Coagulation Inflammation Index(Kare Publ, 2024) Ozkan, Ugur; Gurdogan, MuhammetObjective: Early diagnosis of septic emboli is crucial to prevent the associated morbidity and mortality. This study aimed to examine the relationship between the systemic coagulation inflammation index (SCII) and septic embolism in patients with infective endocarditis (IE). Methods: We retrospectively analyzed the data of 167 IE patients treated at our tertiary care hospital between January 2007 and January 2023. We collected information on symptoms, comorbidities, predisposing valve diseases, prosthetic valves, devices, history of injectable drug use, blood culture results, echocardiographic findings, and complications. The SCII index was calculated using the formula: [platelet count (PLT) x fibrinogen level (g/L) / white blood cell count (WBC)]. Results: The mean age of the patients was 61 years, with rheumatic valve disease being the most common predisposing factor. The most common etiologic microorganism was Staphylococcus species. Septic embolism developed in 25.7% of the patients, with the cerebral system being the most commonly affected (46.5%). The SCII was identified as an independent marker for the development of septic embolism. Receiver operating characteristic (ROC) curve analysis confirmed that an optimal SCII value of 59.8 predicted septic emboli with a sensitivity of 65.1% and a specificity of 59.6% (area under the ROC curve: 0.649 [95% confidence interval (CI): 0.556 - 0.743], P = 0.004). Conclusion: This study demonstrates that high SCII levels are an independent predictor for the development of septic embolism in patients with IE.Öğe A Novel Predictor of Chemotherapeutic Cardiotoxicity in Patients with Non-Hodgkin Lymphoma(Karger, 2019) Gurdogan, Muhammet; Ozkan, UgurBackground: It is known that chemotherapeutic agents cause myocardial cell damage leading to left ventricular dysfunction and heart failure. Fragmented QRS is an indication of fibrosis developing as a result of myocardial cell damage. The aim of this study is to assess whether there is a relationship between the chemotherapeutic treatment and the development of the fragmented QRS complex in electrocardiography (ECG). Patients and Methods: Among 130 patients who were diagnosed with non-Hodgkin lymphoma and received an R-CHOP treatment regimen, the potential emergence of fragmented QRS on ECG as well as the changes in the left ventricular ejection fraction (LVEF) (on transthoracic echocardiography) in response to various chemotherapeutic regimens were sought. Results: New development of a fragmented QRS pattern was observed in 53 of the 130 patients (40.8%). These patients were found to have lower LVEF values along with higher numbers of chemotherapy courses and cumulative doses. In the logistic regression analysis, age (OR = 1.042; 95% CI 1.009-1.076; p = 0.012) and number of courses (OR = 1.848; 95% CI 1.409-2.423; p < 0.001) were found to be the most important predictors of fragmented QRS development. In subjects with a fragmented QRS pattern, there was a significant difference between the initial and repeat LVEF values (p < 0.001). Importantly the emergence of a fragmentation pattern occurred much earlier compared to the drop in LVEF values (10.62 +/- 4.04 vs. 15.24 +/- 7.49 months). Conclusion: Development of a fragmented QRS pattern in response to cancer therapy emerges as a new parameter potentially predictive of chemotherapy-induced cardiotoxicity.Öğe Novel Predictor of the AF Development in Patients with OSAS: Importance of Visceral Adipose Index(Galenos Publ House, 2023) Ozkan, Ugur; Gurdogan, MuhammetObjective: Obstructive sleep apnea syndrome (OSAS) is a sleep disorder whose frequency is increasing daily due to modern lifestyle. Patients with atrial fibrillation (AF), which has the same predisposing factors, frequently visit the outpatient clinic with complaints of palpitation. Existing symptoms are often associated with the course of OSAS, and the development of AF, a disease with high morbidity and mortality, cannot be detected. In our study, we investigated the relationship between the visceral adiposity index (VAI) and AF development in these patients. Methods: We retrospectively analyzed 207 patients with OSAS who visited the cardiology outpatient clinic. The data of 44 patients with AF and 163 patients without AF were compared. Results: Demographic characteristics and clinical risk factors were similar between the groups (p>0.05). VAI, apnea-hypopnea index, and inflammatory markers were higher in the AF group, and these risk factors were significant in the multivariate analysis (p<0.05). Conclusions: Our study is important in terms of showing VAI as one of the most important predictors of AF, which has an impact on mortality and morbidity in patients with OSAS, whose frequency is increasing daily. Further prospective studies are required to confirm our observations and determine their clinical applicability.Öğe The Relationship between Diffusion-Weighted Magnetic Resonance Imaging Lesions and 24-Hour Rhythm Holter Findings in Patients with Cryptogenic Stroke(Mdpi, 2019) Gurdogan, Muhammet; Kehaya, Sezgin; Korkmaz, Selcuk; Altay, Servet; Ozkan, Ugur; Kaya, CaglarBackground and objectives: Cranial magnetic resonance imaging findings of patients considered to be cryptogenic stroke may be useful in determining the clinical and prognostic significance of arrhythmias, such as atrial premature beats and atrial run attacks, that are frequently encountered in rhythm Holter analysis. This study was conducted to investigate the relationship between short atrial runs and frequent premature atrial contractions detected in Holter monitors and infarct distributions in cranial magnetic resonance imaging of patients diagnosed with cryptogenic stroke. Materials and Methods: We enrolled the patients with acute ischemic stroke whose etiology were undetermined. We divided the patients in two groups according to diffusion-weighted magnetic resonance imaging as single or multiple vascular territory acute infarcts. The demographic, clinical, laboratory, echocardiographic, and rhythm Holter analyses were compared. Results: The study investigated 106 patients diagnosed with cryptogenic stroke. Acute cerebral infarctions were detected in 31% of the investigated patients in multiple territories and in 69% in a single territory. In multivariate logistic regression analysis, the total premature atrial contraction count (OR = 1.002, 95% CI: 1.001-1.004, p = 0.001) and short atrial run count (OR = 1.086, 95% CI: 1.021-1.155, p = 0.008) were found as independent variables that could distinguish between infarctions in a single or in multiple vascular territories. Conclusions: Rhythm Holter monitoring of patients with infarcts detected in multiple vascular territories showed significantly higher premature atrial contractions and short atrial run attacks. More effort should be devoted to the identification of cardioembolic etiology in cryptogenic stroke patients with concurrent acute infarcts in the multiple vascular territories of the brain.Öğe Should Bioprosthetic Valves be Implanted in Patients with Aortic Stenosis having a Low Surgical Risk? A Perspective with Pros and Cons(Galenos Publ House, 2024) Ozkan, Ugur; Gurdogan, Muhammet; Kaya, Caglar; Ari, Hasan[Abstract Not Available]Öğe Systemic Immune-Inflammation Index: A Novel Predictor of Coronary Thrombus Burden in Patients with Non-ST Acute Coronary Syndrome(Mdpi, 2022) Ozkan, Ugur; Guerdogan, Muhammet; oeztuerk, Cihan; Demir, Melik; Akkus, Oemer Feridun; Yilmaz, Efe; Altay, ServetBackground and Objectives: Excessive coronary thrombus burden is known to cause an increase in mortality and major adverse cardiac events (MACEs) in NSTE-ACS (non-ST acute coronary syndrome) patients. We investigated the association between the systemic immune-inflammation index (SII) and coronary thrombus burden in patients with non-ST segment elevation myocardial infarction (NSTEMI) who underwent coronary angiography and percutaneous coronary intervention (PCI). Materials and Methods: A total of 389 patients with the diagnosis of NSTEMI participated in our study. Coronary thrombus burden was classified in the TIMI (thrombolysis in myocardial infarction) thrombus grade scale and patients were divided into two groups: a TIMI thrombus grade 0-1 group (n = 209, 157 males) and a TIMI thrombus grade 2-6 group (n = 180, 118 males). Demographics, angiographic lesion images, coronary thrombus burden, clinical risk factors, laboratory parameters, and SII score were compared between the two groups. Results: The high thrombus burden patient group had a higher neutrophil count, WBC count, platelet count, and systemic immune-inflammation index (SII) (p < 0.001). The receiver operating characteristic (ROC) curve analysis showed that at a cutoff of 1103, the value of SII manifested 74.4% sensitivity and 74.6% specificity for detecting a high coronary thrombus burden. Conclusions: Our study showed that the SII levels at hospital admission were independently associated with high coronary thrombus with NSTEMI.Öğe Takotsubo cardiomyopathy: a potential complication in the setting of acute prosthetic valve dysfunction(Polskie Towarzystowo Kardiologiczne, 2021) Yalta, Kenan; Ozkan, Ugur; Yalta, Tulin; Yetkin, Ertan[Abstract Not Available]Öğe Takotsubo syndrome in association with pheochromocytoma: clinical and practical considerations(Pagepress Publ, 2021) Yalta, Kenan; Ozkan, Ugur; Yalta, Tulin; Yetkin, Ertan[Abstract Not Available]Öğe WHAT DO COLLEGE OF SPORTS STUDENTS THINK ABOUT SUDDEN CARDIAC DEATH IN ATHLETES?(Carbone Editore, 2019) Gurdogan, Muhammet; Gurdogan, Eylem Pasli; Ozkan, Ugur; Kurt, CemBackground: The unexpected loss of athletes due to sudden cardiac death on the sports arena is a tragic event that quickly creates worldwide repercussions. This study was conducted as a descriptive study to determine the knowledge and opinion of sports college students about sudden cardiac death in athletes. Methods: The study was conducted with 691 students attending the college of sports at a particular university. The data was collected using a semi-structured questionnaire containing information on the socio-demographic characteristics of the students and their knowledge and opinion on sudden cardiac death in athletes. Frequency, percentage and mean values were used in the evaluation. Results: The mean age of the participants was 20.7 +/- 2.3 years and 56.2% of them were males. 65.4% of the students do not know what sudden cardiac death is and 22.9% think that the most common cause of sudden cardiac death in athletes is the use of performance-enhancing substance. Students consider the use of performance-enhancing substance (81.6%) and the intensity of sports performed (55.9%) as the most important risk factors for sudden cardiac death. Students believe that sudden cardiac death can be prevented by means of detailed and regular health check ups (41.7%) and education of athletes and trainers about preventing sudden cardiac death (27.9%). Conclusion: The results of the study show that sports college students have insufficient information about the causes of sudden cardiac death in athletes and the precautions to be taken in this regard. Education on the subject of sudden cardiac death in athletes is considered necessary for increasing the level of knowledge and awareness of students.
