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Öğe Association of eNOS Glu298Asp gene polymorphism with ischemic stroke in Turkish patients(Wiley-Blackwell, 2008) Guldiken, B.; Sipahi, T.; Guldiken, S.; Ustundag, S.; Turgut, N.; Budak, M.; Ozkan, H.[Abstract Not Available]Öğe Asymmetric dimethylarginine and nitric oxide levels in migraine during interictal period(Wiley-Blackwell, 2008) Guldiken, B.; Demir, M.; Guldiken, S.; Turgut, N.; Ozkan, H.; Kabayel, L.; Tugrul, A.[Abstract Not Available]Öğe Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period(Elsevier Sci Ltd, 2009) Guldiken, B.; Demir, M.; Guldiken, S.; Turgut, N.; Ozkan, H.; Kabayel, L.; Tugrul, A.Nitric oxide (NO), which modulates endothelial function, is thought to be pivotal in the pathophysiology of migraines. The connection between migraine and cardiovascular diseases has also drawn attention to the endothelial dysfunctions and NO pathway abnormalities seen in patients with migraine. Our goal was to assess the levels of NO and the endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), in people with migraine during the interictal period. A total of 49 patients with migraine and 22 control subjects were enrolled in the study. Their plasma NO metabolites (nitrite [NO2-] and nitrate [NO3-]) and ADMA levels were measured using the enzyme-linked immunosorbent assay method, and were then compared with their cardiovascular risk factors, anthropometric measurements, and headache frequency and severity. The plasma ADMA, NO2 and NO3 levels of the patients with migraine during the interictal period did not differ from the control group, and no relationship was found between cardiovascular risk factors and migraine attack severity and frequency. We conclude that, in patients with migraine, there is no dysfunction of baseline NO and ADMA metabolism during the interictal period. (C) 2008 Elsevier Ltd. All rights reserved.Öğe No DNA loss in autotetraploids of Arabidopsis thaliana(Wiley, 2006) Ozkan, H.; Tuna, M.; Galbraith, D. W.To address the issue of genome evolution in autopolyploids and particularly to investigate whether rapid sequence elimination also occurs in autopolyploids as in allopolyploids, amplified fragment length polymorphism (AFLP) fingerprinting was employed to examine a large number of genomic loci in F-1 hybrids between two different autotetraploids of Arabidopsis thaliana accessions, namely Ler and Col. Using this approach, perfect additivity in the F-1 hybrids was found between the newly-formed autopolyploids when compared with their parental lines. Using flow cytometry, the study was extended in a quantitative manner, in which the nuclear DNA contents in one autotetraploid A. thaliana accession Ler, was determined. The increase in genome size of the autotetraploid line was additive. Taken together, no evidence was found for genome size reduction due to autopolyploidization of A. thaliana. The results indicating that there was no DNA loss in autotetraploid A. thaliana suggest that a different type of genome evolution may occur in autopolyploids during the initial stages of their formation when compared with allopolyploids.Öğe Polymorphisms of the angiotensin-converting enzyme and angiotensin II receptor type 1 genes and association with stroke in Turkish subjects of the Trakya region(Wiley-Blackwell, 2008) Sipahi, T.; Guldiken, B.; Budak, M.; Guldiken, S.; Ustundag, S.; Turgut, N.; Ozkan, H.[Abstract Not Available]Öğe Soluble CD40 ligand and prolactin levels in migraine patients during the interictal period(Wiley-Blackwell, 2010) Guldiken, S.; Guldiken, B.; Demir, M.; Kabayel, L.; Ozkan, H.; Turgut, N.; Hunkar, R.[Abstract Not Available]
