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    ASSOCIATION OF ANGIOTENSINOGEN T174M AND M235T GENE VARIANTS WITH DEVELOPMENT OF HYPERTENSION IN TURKISH SUBJECTS OF TRAKYA REGION
    (Taylor & Francis Ltd, 2008) Basak, A. Ay; Sipahi, T.; Ustundag, S.; Ozgen, Z.; Budak, M.; Sen, S.; Sener, S.
    Genetic determinations of human essential (primary) hypertension are discussed reviewing the candidate genes. Angiotensinogen (AGT) gene, coding the precursor of potent vasoactive hormone angiotensin II, in renin- angiotensin-system (RAS) has been reported to be associated with the onset of hypertension. The aim of this study was to investigate the role of variation in the 174 and 235 sites in exon 2 in AGT gene in the developing of primary hypertension in Turkish subjects from Trakya region. Our study involved 136 subjects, 84 hypertensive and 52 gender and age matched controls. T174M and M235T polymorphisms of the AGT gene were investigated using allele specific polymerase chain reaction (PCR) assay and restriction fragment length polymorphism (RFLP). The frequency of genotypes of the variant T174M in the patients with primary hypertension was TT=%73.8, TM=%26.2, and MM=%0.0, that were not different from the controls TT=%73.1, TM=%26.2, and MM=%1.9. And for M235T; the genotype frequencies in patients with primary hypertension were MM=%19.0 MT=%54.8, and TT=%26.2, which were again not significantly different from that of the controls MM=%26.9 MT=%46.2 and TT=%26.9. In conclusion this study, shows that T174M and M235T variants of the AGT gene were not associated with primary hypertension in Turkish subjects from Trakya region.
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    LACK OF EVIDENCE FOR CONTRIBUTION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE INTRON 4 VNTR GENE POLYMORPHISMS TO DEVELOPMENT OF ISCHEMIC STROKE IN TURKISH SUBJECTS
    (Taylor & Francis Ltd, 2009) Sipahi, T.; Basak, A. A.; Ozgen, Z.; Aksoy, A.; Omurlu, I. K.; Palabiyik, O.; Cakina, S.
    The gene polymorphisms of the vasodilator endothelial nitric oxide synthase (eNOS) are considered as important candidate genetic risk factors for vascular diseases. The present study aimed to assess the genotypic distribution and the allelic frequency of the four repeals (a allele), and the five repeats (b allele) of 27 bp in intron 4 of eNOS gene (eNOS VNTR 4 a/b) in Turkish ischemic stroke patients compared to controls. The study population included 197 (102 males, 95 females) patients with ischemic stroke which were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) as large vessel disease or small vessel disease patients, and 144 (36 males, 108 females) controls. The eNOS VNTR 4 a/b gene polymorphisms were identified with a polymerase chain reaction. Genotypes were defined as aa; 394 bp fragment, ab; 394 and 421 bp fragments, and bb; 421 bp fragment according to the presence of the a and b alleles. In this stroke-control study, we did not find any significant difference in either the genotypic distribution or allelic frequency of eNOS VNTR 4 a/b gene polymorphism between the ischemic stroke patients and the controls (p>0.05). We also did not find any significant difference in either the genotypic distribution or allelic frequency according to gender (p>0.05). In addition, there was also no significant difference for the genotype distribution and the allelic frequency among the stroke subtypes (p>0.05), or according to gender in stroke subgroups (p>0.05). The results suggested the lack of an association between the VNTR 4 a/b gene polymorphisms of eNOS gene and ischemic stroke or between the VNTR 4 a/b gene polymorphisms of eNOS gene and subtypes of ischemic stroke in Turkish population in the Trakya region.