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Öğe The effect of acute and chronic formaldehyde exposure on learning and memory in male and female rats(Taylor & Francis Ltd, 2023) Aydin, Didem Donmez; Taskinalp, Oguz; Ulucam, Enis; Karadag, Hakan; Ozfidan, Gulnur Kizilay; Topuz, Ruhan; Ersoy, OnurAimFormaldehyde is a chemical that lies behind the various systemical failures in organism. Many products that people use contain formaldehyde. Owing to its tissue fixative properties, scientists who work in life sciences are exposed to this substance more than others. Several studies have shown that formaldehyde affects the CA1 and CA3 regions of the hippocampus, which play crucial roles in memory consolidation. In this study, we aimed to investigate anxiety levels and indicate the short and long term effects of formaldehyde and sex-related differences by exposing formaldehyde to male and female rats.Materials and MethodsFormaldehyde (10 mg/kg) was administered intraperitoneally for 7 days for acute exposure and 30 days for chronic exposure. Cognitive assessment was performed using fear conditioning, elevated plus maze, and Morris water maze tests. TUNEL staining was used to identify apoptosis in the brains obtained after decapitation.ResultsExposure to intraperitoneal formaldehyde does not impair learning and memory in acute and chronic periods and has no effect on depression or anxiety. After acute exposure, apoptosis was observed in the hippocampal CA1 and CA3 regions in males. When the cognitive test results were examined, no differences were found between the experimental and control groups. There was also no significant difference between males and females.Öğe Effects of Cannabinoid Receptor Blockers on Serum Nesfatin-1/Nucb2 Levels in REM sleep Deprived Mice(Wiley-Blackwell, 2016) Kaya, Oktay; Yilmaz, M. Elif; Bayram, Sinasi; Gunduz, Ozgur; Ozfidan, Gulnur Kizilay; Ozturk, Levent[Abstract Not Available]Öğe Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study(Taylor & Francis Ltd, 2016) Capar, Gonca Duygu; Sapmaz-Metin, Melike; Kutan, Esma; Tomruk, Ceyda Ozcakir; Yalcin, Gul Merve; Er, Nilay; Ozfidan, Gulnur KizilayThe aim of this study is to investigate the effect of doxycycline collagen sponge on bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the level of serum biomarkers as an indicator of osteonecrosis. Twenty-four rats were divided into four groups. Animals in the control group were injected with saline and animals in Groups I, II and III were injected with zoledronate three times a week for eight weeks. After eight weeks, the following procedures were performed in each group. In Group I: extraction of maxillary first molar, in Group II: extraction of maxillary first molar and mucoperiosteal coverage was performed and in Group III: extraction of maxillary first molar and mucoperiosteal coverage with doxycycline collagen sponges was performed. At the end of 16 weeks, all animals were sacrificed. Serum collagen type I C-telopeptide (CTx), tartrate-resistant acid phosphatase (TRACP 5b) and alkaline phosphatase (ALP) levels' analysis, clinical examination, histological and histomorphometrical analysis were performed. As a result no significant difference in CTx, TRACP 5b and ALP levels was observed between groups. Complete mucosal healing was observed in all animals in the control group and 66.7% of animals in Group III. The necrotic bone area in Group III was significantly lower than the other groups (p < 0.01). Statistically significant difference was observed between groups in terms of detached osteoclast number (p < 0.01). In conclusion, local application of doxycycline could have a positive effect in reducing the risk of BRONJ in rats.