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    Elevated platelet-monocyte complexes in patients with psoriatic arthritis
    (Taylor & Francis Ltd, 2009) Pamuk, Guelsuem Emel; Pamuk, Oemer Nuri; Orum, Hueseyin; Arican, Oezer; Turgut, Burhan; Demir, Muzaffer
    We evaluated platelet and endothelial activation parameters in psoriatic arthritis (PsA), a disease reported to be associated with the development of endothelial dysfunction and increased atherosclerotic complications. Twenty patients with PsA, eight psoriasis and 20 healthy controls were included into the study. The patients' clinical features and acute phase parameters were assessed. In all patients and controls, platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), and basal and ADP-stimulated P-selectin expression were determined with flow cytometry; soluble E-selectin (sE-selectin) and soluble CD40L (sCD40L) were determined with ELISA. Patterns of joint involvement and degrees of skin involvement in PsA patients were assessed. PMC in PsA patients were significantly higher than in the control group (p = 0.02). PNC were not significantly different among the three groups (p values > 0.05). sE-selectin levels in both PsA and psoriasis groups were significantly higher than in healthy controls (p values, respectively, <0.001 and 0.023). Basal and ADP-stimulated CD62P expression and sCD40L level were similar in all groups (p values > 0.05). Polyarticular PsA patients had significantly higher sCD40L than oligoarticular plus spondylitic PsA groups (p = 0.04). sCD40L level was higher in active PsA group than in inactive PsA group (p = 0.03). Groups with limited and extensive skin involvement did not differ significantly in the evaluated parameters. C-reactive protein (CRP) level in PsA patients correlated with sCD40L (r = 0.69, p = 0.012), basal CD62P expression (r = 0.89, p < 0.001) and ADP-stimulated CD62P expression (r = 0.73, p = 0.001). Endothelial activation might be have a role in the pathogenesis of both psoriasis and PsA. Among parameters of platelet activation, only PMC might play a role in the pathogenesis of PsA.
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    Might platelet-leucocyte complexes be playing a role in major vascular involvement of Behcet's disease? A comparative study
    (Lippincott Williams & Wilkins, 2010) Pamuk, Guelsuem Emel; Pamuk, Omer Nuri; Orum, Hueseyin; Demir, Muzaffer; Turgut, Burhan; Cakir, Necati
    We determined platelet-leucocyte complexes, which play roles in the thrombosis-inflammation relationship, in Behget's disease patients with and without major vascular involvement (MVI) and in healthy controls. We included 36 Behget's disease patients (22 male, 14 female, mean age: 34.4 +/- 8.3 years) and 20 healthy individuals (14 male, six female, mean age: 31.8 +/- 4.4 years). Whole blood count, CRIP and ESR were determined in both groups. Clinical data about the patients were obtained from medical charts. Individuals with hypertension, diabetes, coronary artery disease, and smokers were excluded. Behcet's disease patients with MVI were taken as a separate group (8 male, 5 female, mean age: 37 +/- 8 years). MVI was defined as the presence of pulmonary arterial aneurysm, deep venous thrombosis, vena cava inferior or superior thrombosis, or venous sinus thrombosis. Flow cytometry was used to determine platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), basal and adenosine diphosphate (ADP)-stimulated platelet CD62P expression. Behget's disease patients with MVI had significantly higher PNC than Behcet's disease patients without MVI and healthy controls (P values=0.01). PMC levels in Behcet's disease patients with MVI were significantly higher than in healthy controls (P=0.01). The groups were similar in basal and ADP-stimulated platelet CD62P expression (P values >0.05). Basal and ADP-stimulated CD62P expression, PMC and PNC were not significantly different between active Behget's disease versus inactive Behget's disease patients. The evaluated parameters were similar in Behget's disease patients with and without uveitis, and pathergy-positive and pathergy-negative groups. Our results might suggest that the formation of PMC and PNC might play a role in thrombosis and MVI of Behget's disease. Blood Coagul Fibrinolysis 21:113-117 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.