Yazar "Onur, Sirin Guner" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Spatial-temporal variability and probabilistic health risk assessment of fluoride from lentic ecosystem, Turkiye
    (Taylor & Francis Ltd, 2023) Tokatli, Cem; Onur, Sirin Guner; Dindar, Mediha Buyukgoze; Malafaia, Guilherme; Islam, Abu Reza Md Towfiqul; Muhammad, Said
    Thrace Region is a part of the Marmara Region of Turkiye. There are many natural and artificial stagnant water habitats in the region that are used for irrigation and drinking water supply. This study is intended to determine the spatial-temporal variability and probabilistic health risk of fluoride exposure in the water of stagnant water bodies in the Thrace region. A total of 33 stagnant water bodies were selected, and water samples were collected during the dry and wet seasons of 2021-2022. The fluoride levels were measured using a spectrophotometric method (wavelength is 588 nm). The fluoride accumulations varied from 0.16-0.64 mg/L for the natural lakes, 0.04-0.74 mg/L for the reservoirs, and 0.01-0.53 mg/L for the artificial ponds. The World Health Organization (WHO) suggested a level of fluoride in drinking water of 0.5 to 1.5 mg/L. The study area had a fluoride deficiency of less than 0.5 mg/L in natural water bodies during the wet season (87.87%) and the dry season (93.93%), which might be a potential threat to dental health. Estimation Daily Intake (EDI) and Hazard Quotient (HQ) widely used health risk assessment methods were applied to the data in the current research to describe the non-carcinogenic risk of fluoride. All the calculated hazard quotient (HQ) values, both in the dry and wet seasons and in all age groups, were recorded as below 1. Both teenagers and children living in the central part of the study area are at higher risk than infants and adults. To evaluate model uncertainty, Monte Carlo simulations were employed. The outcome of the sensitivity analysis revealed that the major risks to the health of the inhabitants are the high content of fluoride and their daily intake of water.
  • Küçük Resim Yok
    Öğe
    Two-fold excess of fluoride in the drinking water has no obvious health effects other than dental fluorosis
    (Elsevier Gmbh, 2018) Sezgin, Batin Ilgit; Onur, Sirin Guner; Mentes, Ali; Okutan, Alev Eda; Haznedaroglu, Eda; Vieira, Alexandre Rezende
    Background. There is concern that fluorides in the drinking water is hazardous to health. Methods: We conducted an observational study in the village of Hanliyenice (population 280), Turkey, which has 2.5 times higher than optimal levels of fluoride in the drinking water and evaluated all children 7-13 years of age (N = 30). We collected information on dental decay, fluorosis, daily water consumption and diet, child history and her family history of cancer, cardiovascular risks/diseases, and asthma, and obtained a blood sample for extraction of genomic DNA. We genotyped ten single nucleotide polymorphisms in aquaporins. Results: As expected, a high number of children were dental caries free (19 out of 30) and had fluorosis (25 out of 30). Family history of cancer, cardiovascular events, and asthma was not different from the expected figures based on Turkey. One variant just upstream of AQP5 was associated with being fluorosis free. (G allele of AQP5 rs296763, p = 6.0E(-6)). Conclusions: Exposure to levels of fluoride twice as high than the optimum in the drinking water increases the prevalence of fluorosis, dramatically decreases dental caries, and does not increase the risk of cancer, cardiovascular events, and asthma.