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Öğe The Analysis of Patients Admitted to the Emergency Department Due to Complications Related to Warfarin Treatment(Aves, 2014) Sayhan, Mustafa Burak; Oguz, Serhat; Yuksel, Volkan; Huseyin, Serhat; Sayhan, Esin Secgin; Yagci, GokceObjective: Warfarin is the most commonly used oral anticoagulant around the world. The most important complication of warfarin is bleeding. This study was conducted to evaluate the patients who were admitted to our emergency department due to complications related to warfarin treatment. Material and Methods: Eighty-nine patients (32 females, 57 males) were enrolled into this retrospective study. The patients were evaluated according to their age, gender, duration of therapy (year), co-administered drugs, bleeding localization, treatments, amount of blood transfusions, duration of bleeding, initial and after-treatment PT, INR, complete blood count, and aPTT. Results: Mean duration of anticoagulant use was 3.05 +/- 2.87 years. The most common indication of warfarin was atrial fibrillation. The most frequent bleeding localization was the upper gastrointestinal tract. Thirty-four (38.2%) of the patients had major bleeding, and 55 (61.8%) had minor bleeding. Age, co-administered drugs, amount of erythrocyte suspension transfusion, presence of previous warfarin overdose history, Hb levels at admission, and duration of follow-up in the ED were different between the bleeding types. Conclusion: In this study, we found that the bleeding complications of warfarin were associated with the aged population, presence of previous warfarin overdose history, and concomitant drug use.Öğe Antioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in rats(Sage Publications Inc, 2015) Toydemir, Toygar; Kanter, Mehmet; Erboga, Mustafa; Oguz, Serhat; Erenoglu, CengizThe aim of the present study was to assess the influence of curcumin on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated (SH), PH, and PH+curcumin; each group contains eight animals. The rats in curcumin-treated groups were given curcumin (in a dose of 100mg/kg body weight) once a day orally for 7days, starting 3days prior to hepatectomy operation. At 7days after resection, liver samples were collected. The malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione (GSH) levels were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labeling, proliferation index (PI), transferase-mediated 2-deoxyuridine, 5-triphosphate nick end-labeling assay, and apoptotic index (AI) were evaluated at 7days after hepatectomy. As a result, curcumin significantly increased MI and PI and significantly decreased AI in PH rats. Additionally, curcumin remarkably inhibited MDA elevation, restored impaired antioxidant SOD activity and GSH level and also attenuated hepatic vacuolar degeneration and sinusoidal congestion. These results suggested that curcumin treatment had a beneficial effect on liver regenerative capacity of the remnant liver tissue after hepatectomy, probably due to its antioxidative, antiapoptotic, and proliferative properties.Öğe Combined Effectiveness of Honey and Immunonutrition on Bacterial Translocation Secondary to Obstructive Jaundice in Rats: Experimental Study(Int Scientific Information, Inc, 2018) Oguz, Serhat; Salt, Omer; Ibis, Abdil C.; Gurcan, Saban; Albayrak, Dogan; Yalta, Tulin; Sagiroglu, TamerBackground: Obstructive jaundice is a serious, life-threatening condition that can lead to death as a result of sepsis and multiorgan failure due to bacterial translocation. Treatment should be started as soon as possible after diagnosis. Material/Methods: Forty 24-week-old male Sprague Dawley rats, with an average weight of 250 g to 300 g, were included in this study. The rats were randomly placed into five groups, each group consisted of eight rats. The sham group underwent only common bile duct (CBD) dissection and no ligation was performed. CBD ligation was applied to the other groups. After the operation, one CBD group was fed with rat chow only, the others were fed with rat chow supplemented with honey, or immunonutrients, or honey plus immunonutrients. After 10 to 12 days, all rats were sacrificed; blood and tissue samples were collected for biochemical, microbiological, and histopathological evaluation. Results: In the groups that were fed with honey and immunonutrients, alanine aminotransferase (ALT) levels were de- creased significantly compared to the other groups. Statistically significant differences were detected in terms of bacterial translocation (BT) rates among liver and spleen samples, and laboratory values of serum, except for MLNs of the BDL+HI group, when compared to other groups. We found mean mucosal thickness of ileum samples have been improved notably in the BDL+HI group compared to the other groups, especially compared to the C/BDL group. Conclusions: Immunonutrition applied with honey had immunostimulant effects, decreased BT due to an additive effect, and had positive effects on intestinal mucosa.Öğe Combined Effects of Tauroursodeoxycholic Acid and Glutamine on Bacterial Translocation in Obstructive Jaundiced Rats(Galenos Publ House, 2013) Hatipoglu, Ahmet Rahmi; Oguz, Serhat; Gurcan, Saban; Yalta, Tulin; Albayrak, Dogan; Erenoglu, Cengiz; Sagiroglu, TamerBackground: Bacterial Translocation is believed to be an important factor on mortality and morbidity in Obstructive Jaundiced. Aims: We investigated the probable or estimated positive effects of tauroursodeoxycholic acid, which has antibacterial and regulatory effects on intestinal flora, together with glutamine on BT in an experimental obstructive jaundiced rat model. Study Design: Animal experimentation. Methods: Forty adult, male, Sprague Dawley rats were used in this study. Animals were randomised and divided into five groups of eight each: sham (Sh); control (common bile duct ligation, CBDL); and supplementation groups administered tauroursodeoxycholic acid (CBDL+T), glutamine (CBDL+G), or tauroursodeoxycholic acid plus glutamine (CBDL+TG). Blood and liver, spleen, MLN, and ileal samples were taken via laparotomy under sterile conditions for investigation of bacterial translocation and intestinal mucosal integrity and hepatic function tests on the tenth postoperative day. Results: There were statistically significant differences in BT rates in all samples except the spleen of the CBDL+TG group compared with the CBDL group (p=0.041, p=0.026, and p=0.041, respectively). Conclusion: It is essential to protect hepatic functions besides maintaining intestinal mucosal integrity in the active struggle against BT occurring in obstructive jaundice. The positive effect on intestinal mucosal integrity can be increased if glutamine is used with tauroursodeoxycholic acid, which also has hepatoprotective and immunomodulatory features.Öğe DEMOGRAPHIC PROPERTIES AND FACTORS AFFECTING MORTALITY OF ELDERLY PATIENTS RELATED WITH MOTOCYCLE INJURIES(Gunes Kitabevi Ltd Sti, 2013) Sayhan, Mustafa Burak; Sayhan, Esin Secgin; Oguz, Serhat; Kavalci, Cemil; Guler, EbruIntroduction: To determine the socio-demographic attributes, trauma scoring systems' relationship to mortality rates and the factors affecting mortality of the victims of motorcycle accidents (VMAs) over 65 who arrive at the emergency department. Materials and Method: A descriptive study was conducted in a university-based hospital. Patients were divided into two groups: survival (group A) and deceased (group B). Results: A total of 108 patients who were VMAs were identified. 96 patients were in group A and 12 were in group B. We especially noted the existence of internal injuries, head injuries, multiple injuries and alcohol intake (p=0.029) as risk factors affecting mortality. The Injury Severity Score (ISS) and Abbreviated Injury Scale (AIS) were found to be higher in group B compared to group A (p=0.003, 0.001, respectively). The Glasgow Coma Score (GCS), Trauma Injury Severity Score (TRISS) and Revised Trauma Score (RTS) were found to be higher in group A compared to group B (p<0.001 for both). Conclusion: Most of the motorcycle-related injuries in elderly involved men, and occurred in urban areas, during the summer and on weekdays, with a mechanism of falling off the motorbike. Skin and musculoskeletal systems were injured most frequently in our study.Öğe Effect of Dual Mesh Wrap on The Stability of Colonic Anastomosis(Aves, 2021) Albayrak, Dogan; Turkes, Bayram; Can, Nuray; Cakcak, Ibrahim Ethem; Kahya, Eyup; Oguz, Serhat; Hoscoskun, ZekiBACKGROUND/AIMS Colon anastomotic leakage is the cause of significant morbidity and mortality in surgery. Therefore, we aimed to demonstrate experimentally the effect of the conventional method of wrapping them through colo-colonic anastomosis performed by dual patch on anastomotic healing and security. MATERIAL and METHODS The study was conducted at the Experimental Animal Research Unit of the Medical Faculty of Trakya University, Edirne, Turkey. A total of 20 Wistar Albino adult rats were used. The rats were divided into 2 groups: 10 rats in the control group and 10 rats in the dual patch group. All rats underwent partial segmental colon resection, and colo-colonic anastomosis was performed in a single layer with 5/0 polypropylene. For rats in the dual patch group, the anastomosis was wrapped up with a 1-cm-wide dual patch. In the control group, there was no operation on the anastomosis. At 7 days after the procedure, the degree of peritoneal adhesion model previously prepared according to Evans devices laparotomy was used to observe all the rats and colon burst pressure. Both histopathological examination and the examination of the perianastomotic area were performed. RESULTS In the rats that were treated with dual mesh, there was a statistically significant increase in anastomotic line burst pressure (P<.05), a statistically significant increase in collagen amount (P<.05), and a statistically significant decrease in abdominal adhesions (P<.05). CONCLUSION As a result, the colo-colonic anastomosis of winding dual patch, without causing intra-abdominal adhesions, improves security by increasing the anastomosis bursting pressure.Öğe Effect of Leptin and Apelin Preconditioning on Hepatic Ischemia Reperfusion Injury in Rats(Springer India, 2014) Sagiroglu, Tamer; Aksoy, Mustafa Burak; Sagiroglu, Gonul; Tozkir, Hilmi; Oguz, Serhat; Yalta, Tulin; Yagci, Mehmet A.Leptin and apelin are important adipocytokines involved in a variety of endocrine and paracrine functions. The aim of this study was to evaluate the effect of exogenous leptin and apelin preconditioning on hepatic ischemia reperfusion (I/R) injury in rats. Forty mice were assigned to four groups (n = 10): sham-operated control (sham), I/R injury, I/R + leptin (I/R + L), and I/R + apelin (I/R + A). Leptin 100 mu g/kg/day and apelin 2 mu g/kg/day were delivered intraperitoneally starting 3 days prior to surgical procedure in I/R + L and I/R + A groups, respectively. All I/R groups underwent 45 min of warm ischemia, followed by 30 min of reperfusion. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), liver malondialdehyde (MDA) and glutathione (GSH), and liver histopathology were compared between groups. MDA was elevated in I/R, but stayed similar in I/R + L and I/R + A compared to sham. I/R + A had significantly lower MDA compared to I/R. GSH levels did not differ significantly between the groups. ALT and AST were elevated in all I/R groups, but significant reduction was observed in I/R + L and I/R + A compared to I/R. Liver histopathology was mostly mild in I/R + L and I/R + A, in contrast to severe injury observed in the I/R group. Leptin and apelin preconditioning significantly reduced hepatic I/R injury in rats.Öğe Effects of apelin and leptin on renal functions following renal ischemia/reperfusion: An experimental study(Spandidos Publ Ltd, 2012) Sagiroglu, Tamer; Torun, Nese; Yagci, Mehmet; Yalta, Tulin; Sagiroglu, Gonul; Oguz, SerhatThe present study aimed to investigate the effects of apelin and leptin on renal functions following renal ischemia/reperfusion (I/R). A total of 32 rats were divided into four groups. The control group was not induced with ischemia, but was administered normal saline intraperitoneally. Normal saline, apelin and leptin were administered intraperitoneally to the I/R, ischemia/reperfusion and apelin (I/R+A) and ischemia/reperfusion and leptin (I/R+L) groups, in turn for three days prior to the surgical procedure. Blood and urine samples were obtained after 24 h of reperfusion, and scintigraphic examination was performed. Renal damage was evaluated histopathologically. Urea levels of the I/R+L and I/R+A groups were comparable, but were higher compared to that of the control group. The I/R group had the highest urea levels (control, 27 +/- 2; I/R, 120 +/- 15; I/R+A, 75 +/- 10; I/R+L, 80 +/- 11; p<0.001). Creatinine levels were higher in all three ischemic groups compared to the control group. Glomerular filtration rate values of the I/R+A and I/R+L groups were not significantly, but numerically higher compared to that of the I/R group. No pathological damage was observed in any of the animals in the control group. In the I/R group, two animals had moderate and six had severe renal damage, while three had moderate and one had severe renal damage in the I/R+L group. In the I/R+A group, moderate renal damage was found in one animal, while none had severe renal damage. This study demonstrates the functional and histopathological protective effects of leptin and apelin against renal I/R injury.Öğe The Effects of Apelin on Mesenteric Ischemia and Reperfusion Damage in an Experimental Rat Model(Galenos Publ House, 2012) Sagiroglu, Tamer; Oguz, Serhat; Sagiroglu, Gonul; Copuroglu, Elif; Yalta, Tulin; Sayhan, Mustafa Burak; Yagci, Mehmet AliObjective: Intestinal ischemia-reperfusion (I/R) injury is associated with high morbidity and mortality rates. There is ongoing research to find an effective preventive or treatment agent. We aimed to evaluate the effects of apelin 13 (AP) on intestinal I/R injury in a rat model. Material and Methods: Twenty-four male Sprague-Dawley rats aged 6-8 weeks and weighing 280 +/- 20 g were equally divided into three groups (control, I/R and I/R+AP). The control group underwent superior mesenteric artery (SMA) mobilization alone without any clamping. In the I/R and I/R+AP groups, an atraumatic microvascular bulldog clamp was placed across the SMA at its point of origin from the aorta. In the I/R+AP group, 2 mu g/kg/d apelin was administered intraperitoneally. After 60 minutes of ischemia, relaparotomy was performed to remove the microvascular clamp on the SMA for 3 hours of reperfusion. After 3 hours, tissue samples were obtained for biochemical [malondialdehyde (MDA) and glutathione (GSH) levels] and histopathological analyses. Results: MDA levels were significantly higher in the I/R group compared to the control group. Although MDA levels were lower in the I/R+AP group compared to the I/R group, the difference was not statistically significant. There was also no significant difference between the I/R+AP and I/R groups regarding GSH levels. The median histopathological grade was significantly lower in the I/R+AP group compared to the I/R group (p=0.001). Conclusion: Apelin appeared to have a positive effect on oxidative injury; this did not reach statistical significance. Thus, the role of apelin and associated findings in the initial treatment of intestinal ischemia needs further large-scale animal studies before human use.Öğe Effects of Urtica dioica on oxidative stress, proliferation and apoptosis after partial hepatectomy in rats(Sage Publications Inc, 2015) Oguz, Serhat; Kanter, Mehmet; Erboga, Mustafa; Toydemir, Toygar; Sayhan, Mustafa Burak; Onur, HaticeThe present study was performed to investigate the effect of Urtica dioica (UD) on liver regeneration after partial hepatectomy (PH) in rats. A total of 24 male Sprague Dawley rats were divided into three groups: sham-operated, PH and PH+UD; each group contains eight animals. The rats in UD-treated groups were given UD oils (2ml/kg/day) once a day orally for 7days starting 3days prior to hepatectomy operation. At day 7 after resection, liver samples were collected. The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were estimated in liver homogenates. Moreover, histopathological examination, mitotic index (MI), proliferating cell nuclear antigen labeling, proliferation index (PI), transferase-mediated deoxyuridine triphosphate nick end-labeling assay, apoptotic index (AI) were evaluated at day 7 after hepatectomy. As a result, UD significantly increased MI and PI, significantly decreased AI and also attenuated hepatic vacuolar degeneration and sinusoidal congestion in PH rats. UD treatment significantly decreased the elevated tissue MDA level and increased the reduced SOD activity and GSH level in the tissues. These results suggest that UD pretreatment was beneficial for rat liver regeneration after partial hepatectomy.Öğe Evaluation of Risk Factors and Clinical Characteristics of Elderly Patients with Acute Upper Gastrointestinal Hemorrhage(Elsevier Science Bv, 2012) Sayhan, Mustafa Burak; Oguz, Serhat; Umit, Hasan; Sayhan, Esin Secgin; Eralp, Mustafa Onur; Akdur, Gokhan; Kavalci, CemilObjectives Acute upper gastrointestinal hemorrhage (AUGIH) is a life-threatening emergency problem in the elderly population. In this study, we aimed to determine the sociodemographic characteristics, clinical features and the risk factors of the elderly patients presenting to the Emergency Department (ED) with AUGIH. Methods A cross-sectional study was conducted in a university-based hospital. One hundred and ninety-four patients were divided into two groups: Group A (n=128); elderly group (65-79 years) and Group B (n=66); very elderly group (>79 years). Results The mean age was 76.34 +/- 7.91 years. The most frequently presenting symptom was melena (87.1%). Fourteen patients (7.2%) were in shock at the time of bleeding. One hundred and thirty-three patients (68.5%) had a history of rebleeding. Underlying comorbidities were detected in 171 patients (88.1%). There was a significant difference in terms of alcohol abuse and coronary artery disease between the two groups (p=0.038 and p=0.049 respectively). The most frequent endoscopic lesions were peptic ulcer and gastroduodenal erosions in both groups. Conservative medical treatments were applied in most of the patients in both groups, but there were no statistically significant differences in terms of response to conservative medical treatment between the two groups (p=0.892). The overall mortality rate was 11.7% in group A and 19.7% in group B. There were no statistically significant differences in mortality between the two groups (p=0.134). Conclusions Evaluation of risk factors and clinical characteristics of elderly patients with upper gastrointestinal hemorrhage is extremely important. Comorbid diseases and multiple drug use are commonly observed in the elderly patients.Öğe A giant ancient schwannoma mimicking an adnexal mass Case report(Lippincott Williams & Wilkins, 2016) Karakose, Oktay; Pulat, Huseyin; Oguz, Serhat; Zihni, Ismail; Ozcelik, Kazim Caglar; Yalta, Tulin Deniz; Eken, HuseyinIntroduction: Ancient schwannoma is a rare tumor of the peripheral nerve sheath. As degenerative properties are defined histologically, it can be wrongly interpreted as malignant. Case presentation: The case presented here is of a giant ancient schwannoma with a pelvic retroperitoneal location, which was mimicking an adnexal mass. Conclusion: In the rarely seen cases in the retroperitoneum, it may reach very large dimensions.Öğe Occupational injuries admitted to the Emergency Department(Pakistan Medical Assoc, 2013) Sayhan, Mustafa Burak; Sayhan, Esin Secgin; Yemenici, Serap; Oguz, SerhatObjective: To categorise the characteristics, causes and rates of occupational injuries referred to the Emergency Department of a Turkish hospital. Methods: The cross-sectional study was conducted at a university-based hospital in Edirne, Turkey, from January 1, 2010 to May 1, 2011. Parameters evaluated included: gender, age, occurrence mechanism, injury type, injury localisation, sector, season, day of week, injury hours, the types of health insurance, working experience, educational level and outcome. SPSS 15 was used for statistical analysis. Results: A total of 552 patients sustained occupational injuries. The male-to-female ratio was 11.54:1.The mean age of the patients was 36.03 +/- 11.77 years. The injury rate was the highest in the 18-29 age group (n=418; 75.7%). Most cases occurred in the summers (n=172; 31.2%).The largest number of injuries occurred on weekdays (n=184; 33.3%). Most injuries occurred between 8AM and 4PM (n=343; 62.1%). The construction industry had the highest injury rate (n=222; 40.2%). The most common mechanism of injuries was penetrating sharp-object injury (n=224; 40.6%). The most common type of injury in the general injury group was multiple-type (n=162; 29.4%). Of the total, 379 (71.7%) patients were discharged after treatment in the Emergency Department. Five patients died during the study period. Conclusion: Further studies in the Emergency Department may contribute to the prevention of occupational injuries in the future.Öğe Protective effect of Urtica dioica L. on renal ischemia/reperfusion injury in rat(Springer, 2012) Sayhan, Mustafa Burak; Kanter, Mehmet; Oguz, Serhat; Erboga, MustafaRenal ischemia-reperfusion (I/R) injury may occur after renal transplantation, thoracoabdominal aortic surgery, and renal artery interventions. This study was designed to investigate the effect of Urtica dioica L. (UD), in I/R induced renal injury. A total of 32 male Sprague-Dawley rats were divided into four groups: control, UD alone, I/R and I/R + UD; each group contain 8 animals. A rat model of renal I/R injury was induced by 45-min occlusion of the bilateral renal pedicles and 24-h reperfusion. In the UD group, 3 days before I/R, UD (2 ml/kg/day intraperitoneal) was administered by gastric gavage. All animals were sacrificed at the end of reperfusion and kidney tissues samples were obtained for histopathological investigation in all groups. To date, no more histopathological changes on intestinal I/R injury in rats by UD treatment have been reported. Renal I/R caused severe histopathological injury including tubular damage, atrophy dilatation, loss of brush border and hydropic epithelial cell degenerations, renal corpuscle atrophy, glomerular shrinkage, markedly focal mononuclear cell infiltrations in the kidney. UD treatment significantly attenuated the severity of intestinal I/R injury and significantly lowered tubulointerstitial damage score than the I/R group. The number of PCNA and TUNEL positive cells in the control and UD alone groups was negligible. When kidney sections were PCNA and TUNEL stained, there was a clear increase in the number of positive cells in the I/R group rats in the renal cortical tissues. However, there is a significant reduction in the activity of PCNA and TUNEL in kidney tissue of renal injury induced by renal I/R with UD therapy. Our results suggest that administration of UD attenuates renal I/R injury. These results suggest that UD treatment has a protective effect against renal damage induced by renal I/R. This protective effect is possibly due to its ability to inhibit I/R induced renal damage, apoptosis and cell proliferation.Öğe Protective effect of Urtica dioica on liver damage induced by biliary obstruction in rats(Sage Publications Inc, 2013) Oguz, Serhat; Kanter, Mehmet; Erboga, Mustafa; Ibis, CemThe aim of this study was to evaluate the possible protective effects of Urtica dioica (UD) against liver damage in the common bile duct-ligated rats. A total of 24 male Sprague Dawley rats were divided into three groups, namely, control, bile duct ligation (BDL) and BDL+received UD groups, containing eight animals in each group. The rats in UD-treated groups were given UD oils (2ml/kg) once a day intraperitoneally for 2weeks starting 3days prior to BDL operation. The change demonstrating the bile duct proliferation and fibrosis in expanded portal tracts includes the extension of proliferated bile ducts into the lobules; inflammatory cell infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with UD attenuated alterations in liver histology. The -smooth muscle actin, cytokeratin-positive ductular proliferation and the activity of terminal deoxynucleotidyl transferase dUTP nick end labeling in the BDL were observed to be reduced with the UD treatment. The data indicate that UD attenuates BDL-induced cholestatic liver injury, bile duct proliferation and fibrosis.Öğe Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats(Springer, 2012) Oguz, Serhat; Kanter, Mehmet; Erboga, Mustafa; Erenoglu, CengizThe aim of this study was to examine the preventive and therapeutic effects of thymoquinone (TQ) against cholestatic oxidative stress and liver damage in common bile duct ligated rats. A total of 24 male Sprague-Dawley rats were divided into three groups: control, bile duct ligation (BDL) and BDL + received TQ; each group contain 8 animals. The rats in TQ treated groups were given TQ (50 mg/kg body weight) once a day orally for 2 weeks starting 3 days prior to BDL operation. To date, no more biochemical and histopathological changes on common bile duct ligated rats by TQ treatment have been reported. The application of BDL clearly increased the tissue hydroxyproline (HP) content, malondialdehyde (MDA) levels and decreased the antioxidant enzyme [superoxide dismutase (SOD), glutathione peroxidase (GPx)] activities. TQ treatment significantly decreased the elevated tissue HP content, and MDA levels and raised the reduced of SOD, and GPx enzymes in the tissues. The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells, and neutrophil infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with TQ attenuated alterations in liver histology. The immunopositivity of alpha smooth muscle actin and proliferating cell nuclear antigen in BDL were observed to be reduced with the TQ treatment. The present study demonstrates that oral administration of TQ in bile duct ligated rats maintained antioxidant defenses and reduces liver oxidative damage and ductular proliferation. This effect of TQ may be useful in the preservation of liver function in cholestasis.Öğe Sesamin ameliorates mucosal tissue injury of mesenteric ischemia and reperfusion in an experimental rat model(Termedia Publishing House Ltd, 2019) Sayhan, Mustafa B.; Oguz, Serhat; Salt, Omer; Can, Nuray; Ozgurtas, Taner; Yalta, Tulin D.Introduction: Mesenteric ischemia/reperfusion (I/R) injury is a serious clinical condition. There were a lot of experimental studies performed in the treatment of I/R injury. To our knowledge, this is the first experimental study with effects of sesamin on I/R injury model. We aimed to investigate the protective effect of sesamin on mesenteric I/R injury model. Material and methods: A total of 32 male Sprague-Dawley rats were divided into four groups. Control group: superior mesenteric artery (SMA) exposed without clamping. I/R group: SMA was clamped for 60 min and then reperfused for 2 h. Sesamin group (S): 30 mg/kg sesamin were given for 5 days, and SMA exposed without clamping. I/R + S group: 30 mg/kg sesamin were given for 5 days, SMA was clamped for 60 min, and then reperfused for 2 h. Plasma and tissue oxidant parameters were investigated as well as histopathological evaluation. Results: Plasma and tissue total antioxidant status (TAS) levels were significantly higher in I/R + S group compared to the rest (p < 0.005). The plasma TAS levels in I/R group was significantly low. The highest tissue TAS levels were detected in I/R + S group. The high levels of plasma and tissue TOS were found in I/R + S group. Plasma and tissue OSI levels were significantly higher in I/R group. Histopathologic evaluation showed that the mean level of intestinal tissue injury score in I/R group was 2.75 and 1.38 in I/R + S group. Conclusions: Sesamin helps to protect the intestinal tissue at the cellular level by reducing the oxidative stress and inflammation at both the plasma and tissue levels in the experimental I/R model.Öğe Spleen rupture due to brucellosis(Turkish Surgical Assoc, 2021) Yagmurkaya, Orhan; Oguz, Serhat; Kahya, Eyilp; Aksoy, Huseyin; Albayrak, Dogan; Sagiroglu, TamerBrucellosis is a common zoonotic infection worldwide; it is caused by infection with the bacterial species Brucella and leads to severe diseases in humans and animals. In Turkey, this bacterial species has not been completely eradicated and is commonly found in animals (such as goats or sheep). Brucellosis can lead to various symptoms, affect multiple systems, and cause splenomegaly in the case of spleen involvement. In contrast to traumatic spleen ruptures, spontaneous spleen ruptures are rare and most commonly occur because of infectious causes. A 52-year-old man was treated at our infectious diseases clinic for Brucella endocarditis. Due to sudden abdominal pain, nausea, vomiting, and vertigo, the patient was evaluated by our team of doctors at the same clinic. The patient had widespread sensitivity in the abdominal region, as well as defense and rebound symptoms. Emergency abdominal tomography revealed a ruptured spleen and widespread hemorrhagic fluid in the abdomen. Exploration revealed multiple ruptures in the spleen capsule. The patient underwent splenectomy and did not experience any complications during the postoperative period. Spontaneous spleen rupture is a rare clinical condition that should be considered in patients who are hospitalized at internal medicine clinics for infectious, hematogenic, and metabolic causes, as well as in those who have sudden abdominal pain and hypovolemia.