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Öğe Cardiac metastasis of hepatocellular carcinoma in a young non-cirrhotic patient, to the left ventricle(Elsevier Espana, 2012) Tastekin, Ebru; Usta, Ufuk; Ege, Turan; Kazindir, Gokhan; Kutlu, Ali KemalHepatocellular carcinoma (HCC) is the most common primary tumor of the liver.(1,2) The most common extrahepatic metastatic sites are lung, abdominal lymph nodes and bone, while its cardiac metastasis is rare.(2,3) Metastasis of HCC into the cardiac cavity is mostly caused by direct tumor invasion of vena cava inferior with continuous extension into the right cardiac cavity.(4,5) Right heart metastasis without invasion of inferior vena cava, which may be caused by hematogenous spread of cancer cells, is rarely reported.(6,7) This paper announces an unusual case of isolated involvement of left ventricle (LV) together with myocardial invasion of HCC. Our patient is known to be the first case with isolated HCC metastasis to the left ventricle. Strikingly, the patient was young and non-cirrhotic with negative serum HBsAg, and anti-HCV results.Öğe Congenital Pulmonary Airway Malformation Type 2: A Case Report with Review of the Literature(De Gruyter Open Ltd, 2016) Tastekin, Ebru; Usta, Ufuk; Kaynar, Aysegul; Ozdemir, Cigdem; Yalcin, Omer; Ozyilmaz, Filiz; Kutlu, Ali KemalA congenital pulmonary airway malformation is a rare disorder of the pulmonary airway and a hamartomatous mass of disorganized lung tissues with various degrees of cystic change. A 20-year-old pregnant woman who did not have previous clinical follow-up during her pregnancy visited the gynecology department for her first check on the 19th week of gestation. The sonogram, showed severe hydrops fetalis. Laboratory findings were consistent with non-immune hydrops fetalis. Medical abortion was performed and the fetus was sent to our department for a complete fetal autopsy. Macroscopically, whole parts of the fetus had striking oedema. Massive pleural and peritoneal effusions were seen on dissection. The left lung filled the whole thoracic cavity. The heart was displaced to the right and the right lung was compressed. Microscopically, the left lung mass showed dilated bronchiole-like structures (1-20 mm) that were lined with ciliated columnar cells without any intervening mucinous cells. The subepithelial stroma contained thin, interrupted smooth muscle fibers and elastic connective tissue without cartilage plates. Our case is a very good example of non-immune hydrops fetalis associated with congenital pulmonary airway malformation type 2. Prenatal clinical and ultrasonographic follow-ups during pregnancy are very important for early diagnosis of congenital malformations.Öğe The effectiveness of splenic autotransplantation(Turkish Assoc Trauma Emergency Surgery, 2007) Karaguelle, Erdal; Hoscoskun, Zeki; Kutlu, Ali Kemal; Kaya, Meryem; Baybar, SerkanBACKGROUND The purpose of this study was to establish the effects of spleen autotransplantation on immunity and to examine the viability of autotransplanted spleen tissue. METHODS Three groups were assigned and following operations were performed in twenty New Zealand rabbits. 1st group: sham laparotomy, 2nd group: splenectomy and 3rd group: splenectomy and splenic autotransplantation. Scintigraphic methods, hematological-immunological tests and histopathological examination were used to evaluate the effects of splenic autotransplantation. RESULTS Histopathological findings showed that eight rabbits had splenic regrowth and two had necrosis of autotransplanted splenic tissue. Preoperative hematological and immunological findings compared with those at sixth week postoperatively. In group 3, postoperative immunoglobulin G, immunoglobulin M and interleukin-1 levels were significantly increased when compared with preoperative levels. Between all groups, postoperative leukocyte counts were found to be significantly higher in group 2 comparing with group 1. In group 2, postoperative platelet counts were significantly higher in comparison to group 1 and 3. No statistically significant difference was detected between the groups for immunoglobulin G, immunoglobulin M and interleukin-1 levels. CONCLUSION Conservative treatment is important in patients with splenic injury. However when splenectomy is indicated, splenic autotransplantation into the omentum pouch could be a reliable method for reconstruction of splenic functions and the viability of the implanted spleen tissue can be monitored by scintigraphy and laboratory examination.Öğe Kız çocukta over lokalizasyonlu salt nongestasyonel koryokarsi: Olgu sunumu(2009) Aksu, Burhan; Puyan, Öz Fulya; Altaner, Şamil; Taştekin, Ebru; Kutlu, Ali KemalDokuz yaşındaki hasta karın ağrısı ve şişlik nedeniyle hastanemize başvurmuştur. Ultrasonografik görüntülemede batın sağ alt kadran periçekal bölgede 7x5x5 cm boyutlarında, yoğun içerikli, septasyonlar içeren sıvı lokulasyonu izlenmiş ve ön planda apse lehine yorumlanmıştır. Laboratuvar tetkiklerinde HCG yüksekliği vardı. Bunun dışında yapılan FSH, Estrodiol, LH, total testesteron, androstenodion, CEA, AFP ve 17-OH progesteronu normal sınırlardaydı. Hastaya sağ salpitıgooferektomi, sol over wedge reze ks iyonu, sağ-sol periton biyopsileri ve sağ parakolik lenf nodu diseksiyonu yapılmıştır. Makroskopik olarak sağ over kistik, nekrotik, hemorajik ve solid alanlar içermekteydi. Mikroskopik incelemede nekrotik ve hemorajik alanlarda atipik sitotrofoblastik ve sinsityotrofoblastik hücreler görüldü. Sinsityotrofoblastik hücreler HCG ile dijfuz pozitifti. Ayrıca pankeratin diffüz, inhibin fokal pozitifti. CD99, CD30, CEA, NSE, PLAP, AFP negatifti. 9 yaşındaki kızın överinde pür nongestasyonel koryokarsinom teşhisi konuldu ve vaka literatür eşliğinde sunuldu.Öğe Laryngeal Chondroma: A Rare Diagnosis in This Localization(Hindawi Ltd, 2011) Tastekin, Ebru; Altaner, Semsi; Uzun, Cem; Karasalihoglu, Ahmet R.; Ozdemir, Cigdem; Kutlu, Ali KemalPrimary chondroid tumors of the larynx represent less than 1% of all laryngeal tumors. Most of them are chondromas and they often involve to the cricoid cartilage. A 31-year-old male patient applied to the oto-laryngology service with a history of dysphonia and dyspnea. Microlaryngoscopy revealed 2 cm sized, ill-defined, covered with regular mucosa, porous, and hard mass on posterior surface of crycoid cartilage in subglottic area. Following the excision of the lesion, histopathologic examination revealed as chondroma. Two years later, local recurrence was detected and the diagnosis was again chondroma. There was no complaint of the patient in last 3 and half years of follow-up. Chondroma should carefully be differentiated from chondrosarcoma and the patients should be followed for possible recurrences.Öğe A rare case of angiomyxolipoma: Differential diagnosis from other vascular and myxoid tumors(2010) Usta, Ufuk; Puyan, Öz Fulya; Can, Nuray; Kutlu, Ali Kemal; Sezer, AtakanOtuz altı yaşındaki bir erkek hastanın ensesinde ortaya çıkan bir anjiyomiksolipoma olgusu sunulmaktadır. Lipomatöz tümörlere benign yumuşak doku neoplazileri arasında oldukça sık rastlansa da, anjiyomiksolipom tanısı ile sadece yedi olgu sunumu vardır. Burada tipik anjiyomiksolipom olan yeni bir olguyu sunmaktayız. Histopatolojik olarak bu tümörün en çarpıcı özelliği birbiri içine giren matür yağ dokusu ve hücreden fakir miksoid iğsi hücreli alanlar ve eşlik eden çok sayıda damar yapısıdır. Miksoid iğsi hücreli lipom, vasküler iğsi hücreli lipom, miksoid liposarkom, miksolipom, anjiyolipom ve psödoanjiyomatöz iğsi hücreli lipom anjiyomiksolipom ayırıcı tanıya girebilecek olan lezyonlardır. Bu son derece nadir lezyonun ayırıcı tanısında immunohistokimya oldukça destekleyicidir. Bizim olgumuzda iğsi hücrelerdeki SMA, desmin, S-100 protein ve HMB45 negatifliği ve bunun beraberinde vimentin pozitifliği ve CD34 zayıf pozitifliği tanıya yardımcı olan immunohistokimyasal bulgular olmuştur.Öğe A Rare Diagnosis in Pulmonary Pathology, Solitary Fibrous Tumor of Pleura: Report of Two Cases(Amer Coll Chest Physicians, 2015) Tastekin, Ebru; Kutlu, Inci; Puyan, Fulya Oz; Kutlu, Ali Kemal[Abstract Not Available]