Yazar "Kurt, Nazmi" seçeneğine göre listele
Listeleniyor 1 - 8 / 8
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Comparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102(Imprimatur Publications, 2019) Hacioglu, Muhammet Bekir; Kostek, Osman; Kurt, Nazmi; Kucukarda, Ahmet; Gokyer, Ali; Ustabasioglu, Fethi Emre; Karatas, FatihPurpose: To assess whether regorafenib and TAS-102 treatments are associated with a change in Skeletal Muscle Area (SMA) as well as to compare Skeletal Muscle Mass (SMM) loss levels between regorafenib and TAS-102 treatments and prognostic significance in the patients with metastatic colorectal cancer (mCRC). Methods: A total of 36 mCRC patients, who received regorafenib or TAS-102 in the third-line and subsequent settings were assessed in the analysis. SMM changes were assessed with CT scans findings, and they were categorized into two groups as SMM-loss (SMM decrease >= 2%) and SMM-stable (SMM change <2%). Results: The SMM change after regorafenib therapy was significantly worse compared with TAS-102 therapy (p=0.001). The median overall survival (OS) was longer in SMM-stable group than in SMM-loss group (12.8 months; 95%CI:9.8-15.7) vs. 6.4 months; 95%CI:5.2-7.7, respectively;p=0.04). Cox regression analysis showed that SMM loss was independent prognostic indicator for OS (HR, 2.87; 95%CI: 1.07-7.42, p=0.03). Conclusion: Although patients who received regorafenib had more SMM loss than those who received TAS-102, there was no difference in OS between drugs.Öğe Complete agenesis of dorsal pancreas with pancreatic cyst: A case report(Kare Publ, 2021) Ustabasioglu, Fethi Emre; Kurt, Nazmi; Tuncbilek, NerminAgenesis of the dorsal pancreas (ADP) is extremely rare disease with no specific symptoms and there is no clear pathogenesis. Approximately half of the affected individuals develop diabetes resulting from reduced islet cell mass secondary to lack of endocrine structures. In this case, we aimed to present a 17-year-old female patient with ADP accompanied by a pancreatic cyst.Öğe Contrast nephropathy in cancer patients receiving anti-VEGF therapy: a prospective study(Springer Japan Kk, 2020) Gokyer, Ali; Kucukarda, Ahmet; Kostek, Osman; Hacioglu, Muhammet Bekir; Uzunoglu, Sernaz; Kula, Osman; Kurt, NazmiObjectives Contrast nephropathy risk has been increasing in cancer patients. Nephrotoxic side effects of anti-vascular endothelial growth factor/receptor (anti-VEGF/R) drugs used in oncologic treatment are also prominent. The purpose of this study was to identify the possible association among anti-VEGF/R drugs use and development of the contrast-induced nephropathy (CIN) in patients with cancers. Methods A total of 92 patients were included in this prospective cross-sectional study. Patients whose glomerular filtration rate (GFR) of < 50 ml/min, hemoglobin of < 10 g/dl, and eastern cooperative oncology group (ECOG) score of >= 2 and had received nephrotoxic drugs were not included in the study. Blood samples were collected baseline at pre computed tomography (CT) and day 2, day 3 and day 7 later CT imaging. CIN was defined as either an increased serum creatinine value of 0.5 mg/dl or increased 25% to baseline. CIN frequency between groups receivingand not receiving anti-VEGF/R was compared using the chi-squared test. CIN frequency between bevacizumab and other anti-VEGF/R was also analyzed. Results There were 39 patients in the anti-VEGF/R (+) group and 53 patients in the anti-VEGF/R (-) group. Eleven patients (28%) in the anti-VEGF/R (+) group and 3 patients (5.6%) in the anti-VEGF/R (-) group had CIN (p = 0.006). In the anti-VEGF/R (+) group, 23 patients received bevacizumab (combined with FOLFOX/FOLFIRI), while 16 patients received other anti-VEGF/R (sunitinib, axitinib, regorafenib, aflibercept) effective treatments. CIN ratio in patients who received bevacizumab or other anti-VEGFR therapy was similar (p = 0 = 50). Of the patients, one patient had acute kidney injury leading to death. Conclusion CIN was significantly more frequent in cancer patients who receiving anti-VEGF/R drugs than those not receiving anti-VEGF/R drugs.Öğe Diffusion tensor imaging and diffusion-weighted imaging on axillary lymph node status in breast cancer patients(Turkish Soc Radiology, 2022) Kurt, Nazmi; Kurt, Busem Binboga; Gulsaran, Ugur; Uslu, Burak; Celik, Ahmet Onur; Sut, Necdet; Tastekin, EbruPURPOSE This article will examine the usefulness of diffusion tensor imaging (DTI) and diffusion-weighted imaging (DWI) on the assessment of axillary lymph nodes (ALN) of breast cancer patients. METHODS Axillary lymph nodes in 66 breast cancer patients were examined by DTI and DWI, and the largest lymph node with increased cortical thickness in axilla was selected. Morphological features, apparent diffusion coefficient (ADC), volume anisotropy, and fractional anisotropy values were measured by using a special software. Imaging findings and histopathological results were recorded. RESULTS Metastatic ALN were detected in 43 (65.1%) patients. Cortical thickness of the metastatic ALN was significantly higher than the non-metastatic ALNs (P <.001), and the long-axis-to-shortaxis ratio was significantly lower in metastatic ALNs (P <.001). There was a statistically significant difference between the ALN status and fatty hilum presence (P <.001). Apparent diffusion coefficient values of metastatic ALNs were statistically lower than those of non-metastatic ALNs (P <.001) using a cutoff value of 1.26 x 10(-3) mm(2)/s for b=500 ADC and 1.21 x 10(-3) mm(2)/s for b = 800 ADC which had 97.7% sensitivity and 91.3% specificity. Fractional anisotropy and volume anisotropy values were significantly different between both groups. A cutoff value of 0.47 for b-500 fractional anisotropy had 83.7% sensitivity, 69.6% specificity 69.6% positive predictive value, and 83.7% negative predictive value. A cutoff value of 0.33 for b = 500 volume anisotropy had 76.7% sensitivity, 78.3% specificity, 86.8% positive predictive value, and 64.3% negative predictive value. CONCLUSION Apparent diffusion coefficient value of metastatic ALNs was found to be significantly lower than those of non-metastatic ALN, and DTI metrics of metastatic ALN were found to be significantly higher than those of non-metastatic ALN. Overall, ADC had a better diagnostic performance than morphological features, fractional anisotropy, and volume anisotropy. Diffusion tensor imagingderived diffusion metrics may be used to complement breast magnetic resonance imaging in the future after further standardization of the imaging parameters.Öğe Fibroadenoma of Axillary Ectopic Breast Tissue(Ubiquity Press Ltd, 2021) Kurt, Nazmi; Demirtas, Elif Mercan; Tuncbilek, NerminTeaching point: Ectopic breast fibroadenoma is a rare benign neoplasm that may mimic pathological lymph node clinically and on imaging.Öğe Meme kanseri olgularında aksiller lenf nodunun tanısal ayrımında difüzyon tensör görüntülemenin katkısı(Trakya Üniversitesi, 2019) Kurt, Nazmi; Tunçbilek, NerminÇalışmamızda rutin meme görüntülemesi yapılan olgularda rutin incelemeye ek olarak kontrast madde gerektirmeyen difüzyon tensör görüntülemeyapılarak meme kanserli olgularda, aksiller lenf nodlarının tutulumunda ayırıcı tanıya olan katkısını hesaplamayı amaçladık. Mayıs 2016 – Temmuz 2019 tarihleri arasında, rutin meme manyetik rezonans görüntüleme yanında difüzyon manyetik rezonans görüntüleme ve difüzyon tensör görüntüleme sekansları alınan 66 erişkin kadın hasta çalışmamıza dahil edildi. Malign meme lezyonu olan olgularda lenf nodu için histopatolojik tanıya gidildi. Difüzyon ağırlıklı görüntüler ve difüzyon tensör görüntüler elde olundu. Manyetik Rezonans cihazının konsolunda, özel yazılım aracılığıyla görünür difüzyon katsayısı, fraksiyonel anizotropi, volüm anizotropi değerleri ölçülerek harita görüntüleri hazırlandı. Değerlendirmede aksilladaki en büyük lenf nodu seçilerek bulguları kaydedildi. T2 ağırlıklı görüntülemede kısa eksen çapı ölçüldü. Ayrıca difüzyon ağırlıklı görüntülemedeki görünür difüzyon katsayısı haritasından ölçülen değerleri kaydedildi. Kantitatif değerlendirme amacı ile difüzyon ağırlıklı görüntüleme ve difüzyon tensör görüntülemede görünür difüzyon katsayı haritalarında saptanan alan kullanarak ölçümyapıldı. Metastatik lenf nodlarının görünür difüzyon katsayısı benign lenf nodlarından anlamlı derecede düşük, fraksiyonel anizotropi ve volüm anizotropi değerleri anlamlı derecede yüksek olarak bulunmuştur. Difüzyon tensör görüntülemedeb-200 ve b-500 değerli fraksiyonel anizotropi ve volüm anizotropi değeri göz önüne alındığında, metastatik aksiller lenf nodu olan olgularda benign olanlara kıyasla belirgin yüksek izlenmiş olup istatistiksel olarak anlamlı metastatik-benign aksiller lenf nodu ayrımı yapılabilmektedir (p<0.001). Difüzyon tensör görüntüleme konvansiyonel meme manyetik rezonans incelemeye tamamlayıcı bir sekans olarak kullanılabilir.Öğe Skeletal muscle loss during anti-epidermal growth factor receptor therapy is an independent prognostic factor on non-small cell lung cancer patients survival(Imprimatur Publications, 2021) Kucukarda, Ahmet; Gokyer, Ali; Gokmen, Ivo; Hacioglu, Muhammed Bekir; Kostek, Osman; Kurt, Nazmi; Karabulut, DeryaPurpose: We aimed to assess whether skeletal muscle loss during EGFR thyrosine kinase inhibitor therapy of advance non-small cell lung cancer patients is an independent prognostic factor for progression-free survival (PFS) and overal survival (OS). Methods: A total of 45 patients who had computed tomography images were retrospectively evaluated at the diagnosis and during the treatment period before progression occurs. Results: During treatment 19 patients (42.2%) had skeletal muscle loss. Objective response rates in muscle loss group and muscle stable group were 36.8% and 73.0%, respectively (p<0.01). Median follow-up time was 18.9 months (14.832.1). Median PFS was 14.7 months (95% CI 12.1-17.3) in muscle stable group and 7.6 months (95% CI 6.7-8.5) in muscle loss group (p<0.01). Median OS was 18.3 months (95% CI 16.5-20.2) in muscle loss group while it was 30.1 months (95% CI 22.1-38.2) in muscle stable group (p<0.01). In multivariate analysis for both PFS and OS, skeletal muscle loss was an independent prognostic factor. Hazard ratios (HR) for PFS and OS were 12.2 (95% CI 4.3-34.4) and 3.51 (95% CI 1.41-8.73) respectively. Conclusion: On CT imaging skeletal muscle loss before progression is an independent prognostic factor for both PFS and OS in advance non-small cell lung cancer patients who received EGFR tyrosine kinase inhibitor therapy.Öğe The value of MRI contrast enhancement in biopsy decision of suspicious mammographic microcalcifications: a prospective multicenter study(Springer, 2021) Taskin, Fusun; Kalayci, Cem Burak; Tuncbilek, Nermin; Soydemir, Efe; Kurt, Nazmi; Kaya, Handan; Aribal, ErkinObjectives To investigate the inclusion of breast MRI in radiological assessment of suspicious, isolated microcalcifications detected with mammography. Methods In this prospective, multicenter study, cases with isolated microcalcifications in screening mammography were examined with dynamic contrast-enhanced MRI (DCE-MRI) before biopsy, and contrast enhancement of the relevant calcification localization was accepted as a positive finding on MRI. Six experienced breast radiologists evaluated the images and performed the biopsies. Imaging findings and histopathological results were recorded. Sensitivity, specificity, NPV, and PPV of breast MRI were calculated and compared with histopathological findings. Results Suspicious microcalcifications, which were detected by screening mammograms of 444 women, were evaluated. Of these, 276 (62.2%) were diagnosed as benign and 168 (37.8%) as malignant. Contrast enhancement was present in microcalcification localization in 325 (73.2%) of the cases. DCE-MRI was positive in all 102 invasive carcinomas and in 58 (87.9%) of 66 DCIS cases. MRI resulted in false negatives in eight DCIS cases; one was high grade and the other seven were low-to-medium grade. The false-negative rate of DCE-MRI was 4.76%. The sensitivity, specificity, PPV, and NPV for DCE-MRI for mammography-detected suspicious microcalcifications were 95.2%, 40.2%, 49.2%, and 93.3%, respectively. Conclusions In this study, all invasive cancers and all DCIS except eight cases (12.1%) were detected with DCE-MRI. DCE-MRI can be used in the decision-making algorithm to decrease the number of biopsies in mammography-detected suspicious calcifications, with a tradeoff for overlooking a small number of DCIS cases that are of low-to-medium grade.
